Early Detection of Pervasive Developmental Disorders

早期发现广泛性发育障碍

• 批准号: 8116217
• 负责人: Deborah A. Fein
• 金额: $ 20.78万
• 依托单位: UNIVERSITY OF CONNECTICUT STORRS
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8116217
• 关键词: 2 year old; Academy; Address; Adopted; Affect; Age; Algorithms; American; Autistic Disorder; Bypass; Characteristics; Child; Childhood; China; Clinical; Connecticut; Country; DSM-IV; Data; Data Set; Development; Developmental Diagnostic; Diagnosis; Diagnostic; Disease; Early Diagnosis; Early treatment; Egypt; Evaluation; Family; France; Funding; Germany; Goals; Growth; Guidelines; Health Personnel; Iceland; Intervention; Interview; Ireland; Japan; Measures; Meleagris gallopavo; Netherlands; Outcome; Parents; Pediatrics; Pervasive Development Disorder; Phenotype; Population; Population Characteristics; Population Heterogeneity; Process; Progress Reports; Property; Psychometrics; Puerto Rico; Questionnaires; Recommendation; Resources; Risk; Sampling; Scientist; Screening procedure; Siblings; Spain; Symptoms; Telephone; Testing; Toddler; Translations; Turkey bird; United States Indian Health Service; Universities; Visit; autism spectrum disorder; base; cohort; early childhood; follow-up; high risk; improved; instrument; pediatrician; public health relevance; social communication; tool; user-friendly

DESCRIPTION (provided by applicant): Early detection of Autism Spectrum Disorders (ASD) has come to be recognized as a crucial activity in promoting the best possible outcome for affected children. In our current NICHD-funded Early Detection (ED) study, for which this application is a competing continuation, we have developed an effective screening instrument, the Modified Checklist for Autism in Toddlers (M-CHAT), which is now widely used in the US, and is being studied in translation in other countries and cultures, including Japan, China, Spain, the Netherlands, France, Iceland, Ireland, Germany, Egypt, Puerto Rico and Turkey. It is being used by the Indian Health Service and is included in the American Academy of Pediatrics screening tool kit. In addition to studying the properties of this screening instrument, studying our current cohort of 16-30 month old children detected with the M-CHAT and diagnosed with ASD, has allowed us to address other questions of great theoretical and practical importance concerning early detection and development, including: characteristics of children with ASD screened from high risk vs. unselected samples, characteristics of younger siblings of children with ASD detected at age 1.5 to 2, early predictors of outcome, the application of DSM-IV symptoms to very young children, diagnostic stability through early childhood, validity of diagnostic instruments in 2-year-olds, growth parameters in early development and their relationships to outcome, and whether general developmental screening is sufficient to detect ASD. The overarching goal of this continuation is to validate a final shortened revision of the M-CHAT. This final version will be (a) brief and user-friendly, (b) easy for pediatricians to score in their offices, (c) valid for diverse populations of children, (d) valid for younger siblings, who are at high risk, and (e) ready to be recommended for universal pediatric use in the US, as well as in multiple translations in other countries. Disseminating a finalized, valid screener for early detection of ASD, which is parent- and pediatrician-friendly, will allow a large number of children to have earlier access to intervention and optimize their developmental outcomes. PUBLIC HEALTH RELEVANCE: The goal of this project is to validate a final shortened revision of the M-CHAT, a screener for autism in toddlers. This final version will be (a) brief and user-friendly, (b) easy for pediatricians to score in their offices, (c) valid for diverse populations of children, (d) valid for younger siblings, who are at high risk, and (e) ready to be recommended for universal pediatric use in the US, as well as in multiple translations in other countries. Disseminating a finalized, valid screener for early detection of ASD, which is parent- and pediatrician-friendly, will allow a large number of children to have earlier access to intervention and optimize their developmental outcomes.

描述（由申请人提供）：自闭症谱系障碍（ASD）的早期发现已被认为是促进受影响儿童的最佳结果的关键活动。 In our current NICHD-funded Early Detection (ED) study, for which this application is a competing continuation, we have developed an effective screening instrument, the Modified Checklist for Autism in Toddlers (M-CHAT), which is now widely used in the US, and is being studied in translation in other countries and cultures, including Japan, China, Spain, the Netherlands, France, Iceland, Ireland, Germany, Egypt, Puerto Rico和土耳其。它正在印度卫生服务部使用，并包括在美国儿科筛查工具套件中。除了研究该筛选工具的特性外，研究我们目前的16-30个月大儿童的群体被M-chat检测并被诊断为ASD的儿童，还使我们能够解决其他有关早期发现和发展的伟大理论和实际重要性问题结果，DSM-IV症状在非常小的孩子中的应用，通过幼儿期间的诊断稳定性，2岁儿童诊断工具的有效性，早期发展的生长参数及其与结果的关系以及一般的发展筛查是否足以检测ASD。这种延续的总体目标是验证M-Chat的最终缩短修订。该最终版本将是（a）简短且用户友好，（b）儿科医生在办公室中易于评分，（c）对各种儿童人群有效，（d）对年轻的兄弟姐妹有效，这些兄弟姐妹的风险很高，并且（e）可以在美国以及其他国家 /地区的多种译本中推荐用于普遍的儿童使用。传播最终确定的有效筛选器，以供父母和儿科医生友好的ASD早期检测，这将使大量儿童能够较早获得干预并优化其发育成果。公共卫生相关性：该项目的目的是验证M-Chat的最终缩短修订，这是幼儿自闭症的筛选者。该最终版本将是（a）简短且用户友好，（b）儿科医生在办公室中易于评分，（c）对各种儿童人群有效，（d）对年轻的兄弟姐妹有效，这些兄弟姐妹的风险很高，并且（e）可以在美国以及其他国家 /地区的多种译本中推荐用于普遍的儿童使用。传播最终确定的有效筛选器，以供父母和儿科医生友好的ASD早期检测，这将使大量儿童能够较早获得干预并优化其发育成果。