Vaping in Childhood and Adolescence: Cognitive and Behavioral Consequences

儿童和青少年时期吸电子烟：认知和行为后果

基本信息

批准号：
10703467
负责人：
Neal Doran
金额：
$ 27.65万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-15 至 2027-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10703467
关键词：
Abstinence Address Adolescence Adolescent Affective Age Animals Authorization documentation Behavioral Brain Cardiovascular Diseases Cells Cessation of life Characteristics Charge Child Childhood Chronic Cigarette Cigarette Smoker Clinical Cognitive Cognitive deficits Communities Conflict (Psychology)Consumption Crime DNA Data Set Dependence Development Devices Disease Electronic cigarette Expectancy Exposure to Family Formulation Friends Goals Health High Prevalence High School Student Home Human Individual Inhalation Intervention JUUL Knowledge Learning Life Longitudinal cohort study Lung diseases Marketing Metabolic Diseases Middle School Student Morbidity - disease rate Morphology Nature Neighborhoods Neurocognitive Neurocognitive Deficit Nicotine Nicotine Dependence Outcome Pattern Physiological Policies Policy Maker Population Predictive Factor Predisposition Prevalence Prevention Prevention program Psychological reinforcement Research Risk Risk Factors Safety Self Efficacy Sodium Chloride System Testing Time Tobacco Tobacco Dependence Tobacco use Work Youth airway inflammation authority cigarette smoking cohort combustible tobacco design e-cigarette aerosols effective intervention electronic cigarette use emotion regulation gut inflammation interest intervention program knowledge base modifiable risk mortality neural neurobehavioral nicotine exposure parental monitoring peer peer influence programs prospective prospective test psychologic reduce tobacco use repaired social social media therapy development tobacco products uptake vaping

项目摘要

Project Summary/Abstract The long-term goal of this research program is to identify negative consequences associated with e-cigarettes and other newer tobacco products, and reduce the health burden of tobacco use by developing interventions and identifying policies to reduce youth use. This proposal focuses on e-cigarette use, which has increased substantially and is now the most common nicotine product used by US youth. Our collective knowledge is not yet sufficient to identify factors that can be targeted in e-cigarette interventions, or to be sure that we understand the negative consequences of use. We propose to take advantage of the unique nature of the ABCD study, which includes regular assessments of a large, nationally representative cohort from ages 9 to 19. The design of the study will allow us to examine a range of both (1) modifiable risk factors for e-cigarette use and (2) behavioral, psychological, neurocognitive, and physiological consequences of use. The goals of this study are to prospectively test the following hypotheses: (1) e-cigarette initiation and progression in children is driven by modifiable social, contextual, and individual risk factors; (2) children who try e-cigarettes will be more likely to become users of combustible tobacco products; (3) youth e-cigarette use is associated with neural alterations and neurocognitive deficits; (4) e-cigarette use in adolescence is associated with negative health consequences. Our goals are twofold. First, we seek to identify modifiable factors among children that are associated with risk of chronic tobacco use and dependence, in order to inform intervention development. Second, we aim to delineate the extent to which e-cigarette use causes negative physical, behavioral and cognitive consequences, in order to inform policymakers who have regulatory authority over tobacco products. The overarching goal is to reduce tobacco use among youth and thus associated morbidity and mortality.

项目概要/摘要该研究计划的长期目标是确定与电子烟相关的负面后果和其他新型烟草产品，并通过制定干预措施减轻烟草使用的健康负担并确定减少青少年使用的政策。该提案的重点是电子烟的使用，电子烟的使用增加了基本上是现在美国年轻人最常用的尼古丁产品。我们的集体知识不是但足以确定电子烟干预措施的目标因素，或者确保我们了解使用的负面后果。我们建议利用该项目的独特性 ABCD 研究，其中包括对 9 岁至 9 岁的具有全国代表性的大型队列进行定期评估 19. 该研究的设计将使我们能够检查一系列电子烟的（1）可改变的风险因素使用和 (2) 使用的行为、心理、神经认知和生理后果。本研究的目的是前瞻性地检验以下假设：（1）电子烟的开始和使用儿童的进展是由可改变的社会、背景和个人风险因素驱动的； (2)尝试的孩子电子烟将更有可能成为可燃烟草制品的使用者； (3)青少年电子烟使用情况与神经改变和神经认知缺陷有关； (4)与青春期电子烟使用相关对健康产生负面影响。我们的目标是双重的。首先，我们寻求确定儿童中与风险相关的可改变因素慢性烟草使用和依赖的情况，以便为干预措施的制定提供信息。其次，我们的目标是描述电子烟的使用对身体、行为和认知造成负面影响的程度后果，以便向拥有烟草制品监管权的政策制定者提供信息。这总体目标是减少青少年吸烟，从而减少相关的发病率和死亡率。