Understanding pathogen and host determinants of the natural history of N. gonorrhoeae infection

了解淋病奈瑟菌感染自然史的病原体和宿主决定因素

基本信息

批准号：
10703733
负责人：
JOSEPH A DUNCAN
金额：
$ 72.69万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-06-23 至 2028-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10703733
关键词：
Anatomy Antibiotic Resistance Antibiotic Therapy Antibodies Antibody Response Antigenic Variation Antigens Area Bacteria Bioinformatics Biological Biological Factors Characteristics Clinical Trials Clone Cells Collaborations Communities Data Data Set Development Enrollment Epidemiology Female Female genitalia Gene Expression Profile Genes Genetic Genetic Transcription Genomics Gonococcal urethritis Gonorrhea Human Immune Evasion Immune response Immunity Immunologic Factors Immunology Individual Infection Integration Host Factors Investigation Lactobacillus Longitudinal Studies Longitudinal cohort study Malawi Male Genital Organs Microbiology Minority Modeling Monoclonal Antibodies Multiple Anatomic Sites Natural History Neisseria gonorrhoeae Observational Study Outcome Pathogenesis Periodicals Phase Pilot Projects Play Population Public Health Resistance Resources Risk Sexual Partners Sexually Transmitted Diseases Site Specimen T-Lymphocyte Technology Testing Time Urethritis Vaccines Variant Woman bactericide cervicovaginal clinical care cohort follow-up genital microbiota genome sequencing high risk high risk men infection rate male men microbial community microbial genomics microbiome microbiome analysis microbiota mucosal site multidisciplinary multiple omics novel participant enrollment pathogen pathogen exposure public health intervention response sample collection sex transcriptome transcriptome sequencing transcriptomics transmission process vaccine development vaginal microbiota whole genome

项目摘要

Abstract: Rising antibiotic resistance in N. gonorrhoeae poses a serious, global public health threat. Effective control of N. gonorrhoeae is hampered by asymptomatic infections that allow transmission of the bacteria to uninfected individuals and immune evasion by the bacteria that has limited vaccine development efforts. Understanding the natural history of asymptomatic infection and the immunologic responses that are responsible for clearance of infection. We propose a longitudinal study with close surveillance and of follow up individuals with recent N. gonorrhoeae infection who are at high risk for re-infection. This study will provide a rich data set to understand pathogen exposure and infection outcome. It will also provide a set of biologic specimens to study the pathogen and host factors that contribute to infection clearance as well as asymptomatic carriage and/or progression to symptomatic infection. We will conduct analysis of anti-N. gonorrhoeae antibody and cellular immune responses to inform correlates of protective immunity against gonorrhea. Combined this project will provide important new information that will contribute to public health and vaccine development efforts to reduce the spread of N. gonorrhoeae.

抽象的：淋病奈瑟菌不断上升的抗生素耐药性对全球公共卫生构成严重威胁。无症状感染阻碍了对淋病奈瑟菌的有效控制，这些感染使得将细菌传播给未感染的个体以及细菌逃避免疫疫苗开发工作有限。了解无症状患者的自然史感染和负责清除感染的免疫反应。我们提出一项纵向研究，对近期感染 N. 的个体进行密切监测和随访。淋病感染者，再次感染的风险很高。这项研究将提供丰富的数据设置以了解病原体暴露和感染结果。它还将提供一套生物制剂标本来研究有助于感染清除的病原体和宿主因素作为无症状携带和/或进展为有症状感染。我们将进行抗N分析淋病抗体和细胞免疫反应，以告知相关因素针对淋病的保护性免疫力。该项目结合起来将提供重要的新有助于公共卫生和疫苗开发工作的信息，以减少淋病奈瑟菌的传播。