Washington Metropolitan Women's Interagency HIV Study

华盛顿大都会妇女机构间艾滋病毒研究

• 批准号: 8077775
• 负责人: MARY A YOUNG
• 金额: $ 122.34万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-15 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8077775
• 关键词: Address; Adverse effects; Age; Collaborations; Complex; Consequences of HIV; Country; Data Analyses; Disease; Elements; Enrollment; Epidemiology; Gonadal Steroid Hormones; HIV; HIV Infections; Hepatitis C virus; Human Papillomavirus; Investigation; Neurocognition; Outcome; Protocols documentation; Research Infrastructure; Research Personnel; Scientific Advances and Accomplishments; Site; Specimen; Structure; Washington; Woman; Women Status; age effect; cohort; flexibility; metropolitan; pathogen; repository

DESCRIPTION (provided by applicant): The Washington Metropolitan WINS (WMW) Consortium has enrolled and retained a representative cohort of HIV infected and HIV uninfected women since 1993 with the purpose of investigating the consequences of HIV infection and its treatment. Although significant progress has been made in both our understanding and treatment of HIV, curative therapy is still not available and the chronically administered complex therapies used to treat HIV are not always successful. Treatment with highly active antiretrovirals (HAART) appears to be associated with a wide range of adverse effects and the impact of other co-pathogens such as HPV and HCV has yet to be fully elucidated. Additionally, the early cohort of infected women is aging, and the effects of age and changes in sex steroids both on the long term outcomes of HIV, on neurocognition and the effects of HAART treatment needs investigation. The WMW has joined with centers around the country and with sites across the metropolitan Washington region to develop a scientific plan to address these issues. A successful and flexible infrastructure has been established to allow us to accomplish these scientific aims and to assure ongoing retention of this important cohort. The WMW has successfully participated in all elements of the WIHS protocol, and has actively supported the infrastructure of the national WIHS. WMW investigators have participated in all of the major WIHS scientific initiatives. Additionally, the WMW has established both a local specimen repository and contributes to the national specimen repository. As the study has matured, an increasing number of collaborations have been established with local investigators to allow for broader access to the rich repository of WIHS specimens. Further, the WMW has expanded its local epidemiologic expertise to allow for on site data analyses. This application will describe both our accomplishments to date and the structure that we have established to 1) advance the scientific agenda as outlined in Part A, 2) to continue to expand our local collaboration in order to better define the status of women with HIV, and 3) to bring to fruition the promises of a sustainable treatment of this devastating disease.

描述（由申请人提供）：华盛顿大都会 WINS (WMW) 联盟自 1993 年以来已招募并保留了一组具有代表性的 HIV 感染者和 HIV 未感染女性，目的是调查 HIV 感染的后果及其治疗。尽管我们在对艾滋病毒的理解和治疗方面已经取得了重大进展，但仍然没有治愈性疗法，并且长期施用的用于治疗艾滋病毒的复杂疗法并不总是成功。高活性抗逆转录病毒药物 (HAART) 治疗似乎与多种不良反应相关，而 HPV 和 HCV 等其他共同病原体的影响尚未完全阐明。此外，早期感染女性群体正在老龄化，年龄和性类固醇变化对 HIV 长期结果、神经认知和 HAART 治疗效果的影响需要调查。 WMW 已与全国各地的中心和华盛顿大都市地区的多个站点联合制定科学计划来解决这些问题。我们已经建立了成功且灵活的基础设施，使我们能够实现这些科学目标并确保持续保留这一重要群体。 WMW 已成功参与 WIHS 协议的所有要素，并积极支持国家 WIHS 的基础设施。 WMW 研究人员参与了 WIHS 的所有主要科学举措。此外，WMW 还建立了地方标本库并为国家标本库做出了贡献。随着研究的成熟，与当地研究人员建立了越来越多的合作，以便更广泛地访问丰富的 WIHS 标本存储库。此外，WMW 还扩展了当地流行病学专业知识，以便进行现场数据分析。该申请将描述我们迄今为止所取得的成就以及我们已建立的结构，目的是 1) 推进 A 部分中概述的科学议程，2) 继续扩大我们的当地合作，以便更好地确定感染艾滋病毒的妇女的状况， 3) 实现可持续治疗这种毁灭性疾病的承诺。