The Asia-Pacific HIV Observational Database (APHOD)

亚太艾滋病毒观察数据库 (APHOD)

• 批准号: 8133580
• 负责人: DAVID A COOPER
• 金额: $ 43.42万
• 依托单位: FOUNDATION FOR AIDS RESEARCH
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8133580
• 关键词: AIDS education/prevention; Acquired Immunodeficiency Syndrome; Address; Adverse effects; Affect; Age; Anti-Retroviral Agents; Asia; Asians; Australia; Behavior; Caring; Caucasians; Caucasoid Race; Cause of Death; Characteristics; China; Clinical; Clinics and Hospitals; Code; Data; Data Collection; Data Set; Databases; Developed Countries; Developing Countries; Development; Disease; Disease Outcome; Disease Progression; Drug usage; Economic Development; Economics; Electronics; Epidemic; Epidemiology; Ethnic Origin; Event; Far East; Foundations; HIV; HIV Infections; Health; Hepatitis C; High Prevalence; Highly Active Antiretroviral Therapy; Hodgkin Disease; Home environment; Immune; Immune response; Immune system; Incidence; Individual; Infection; International; Life; Location; Long-Term Effects; Methods; Natural History; Nucleosides; Observational Study; Opportunistic Infections; Outcome; Patients; Pharmaceutical Preparations; Pharmacology; Population; Process; Records; Regimen; Research Personnel; Reverse Transcriptase Inhibitors; Risk; Site; Social Conditions; South Australia; Therapeutic Human Experimentation; Toxic effect; Training; Treatment outcome; Tuberculosis; base; cohort; combat; cost efficient; disease natural history; latent infection; meetings; reconstitution; response; standard of care; success; treatment planning; treatment response; treatment site; trend; tuberculosis treatment

DESCRIPTION (provided by applicant): Much that informs HIV disease and its treatment is derived from the developed world, mainly Caucasian populations. However, in many important respects HIV infection in Asia differs from other regions. The epidemiology of HIV infection is different, including large injecting drug use epidemics. Co-infection rates with hepatitis C and B are substantial. The natural history of HIV infection differs with faster progression rates and a different spectrum of opportunistic infections. There is emerging evidence that the pharmacology and toxicity of antiretroviral (ARV) treatments in Asian populations are different. Combined with differences such as ethnicities and economic development, and the coincident rapid expansion of ARV treatment access, the study of HIV disease and treatment in Asian populations is imperative. This study seeks to examine HIV disease natural history and treatment in Asia, and to assess differences with Caucasian populations. Specific studies will look at the efficacy and toxicity of ARV treatments. Studies of HIV and tuberculosis (TB), including HIV and TB treatment interactions, and immune reconstitution disease will be an important focus. The long-term effects of ARV treatments will be assessed, including trends in causes of death and comparisons with an age and behavior-matched HIV-negative group. The Asia-Pacific HIV Observational Database combines the TREAT Asia HIV Observational Database and the Australian HIV Observational Database, two established studies covering 39 sites in South, South East and East Asia and Australia, and following some 1750 individuals in Asia and 2329 in Australia. Both studies are observational, collecting demographic, treatment, disease outcome and toxicity data. A particular strength is having toxicity and outcome data collected and coded according to identical methods in Asia and Australia, allowing straightforward comparison of Asian and Caucasian populations. Both studies use an electronic transfer method of data collection that has demonstrated to be highly cost efficient while meeting stringent levels of data accuracy. Relevance: Asia (excluding China) is home to over one third of the world's population, and in 2005 some 7 million people living with HIV. It is known that in many important respects HIV epidemiology, natural history and ARV treatment outcomes differ in Asia compared with other regions. Simultaneously, ARV treatment is rapidly expanding. The Asia-Pacific HIV Observational Database aims to examine HIV disease natural history and treatment in Asia, and compare outcomes with Caucasian populations, principally in Australia, to inform optimal care and treatment for HIV disease in the region.

描述（由申请人提供）：许多信息及其治疗的信息源于发达国家，主要是高加索人群。但是，在许多重要方面，亚洲的艾滋病毒感染与其他地区不同。 HIV感染的流行病学不同，包括大量注射药物使用流行病。丙型肝炎和B的共感染率很高。艾滋病毒感染的自然病史随着进展速度更快和机会性感染而不同。有新的证据表明，亚洲人群中抗逆转录病毒（ARV）治疗的药理学和毒性不同。结合种族和经济发展等差异，以及ARV治疗访问的快速扩张，亚洲人群中对艾滋病毒疾病和治疗的研究至关重要。这项研究旨在检查亚洲的HIV疾病自然史和治疗，并评估白人人群的差异。具体研究将研究ARV治疗的功效和毒性。 HIV和结核病（TB）的研究，包括HIV和TB治疗相互作用以及免疫重建疾病将是一个重要的重点。将评估ARV治疗的长期影响，包括死亡原因和与年龄和行为匹配的HIV阴性组的比较趋势。亚太艾滋病毒观察数据库结合了亚洲艾滋病毒观察数据库和澳大利亚艾滋病毒观察数据库，这两项涵盖了在南，东南亚，东亚和东亚和澳大利亚的39个地点的既定研究，以及在亚洲和澳大利亚的1750名个人和2329个遗址。两项研究都是观察性的，收集人口统计学，治疗，疾病结果和毒性数据。一个特殊的优势是根据亚洲和澳大利亚的相同方法收集和编码的毒性和结果数据，从而可以直接比较亚洲和高加索人群。两项研究都使用一种电子传输方法收集的电子传输方法，该方法在达到严格水平的数据准确性的同时证明是高效的。相关性：亚洲（不包括中国）是世界人口中三分之一以上的家，2005年，大约700万人患有艾滋病毒。众所周知，与其他地区相比，在许多重要方面，艾滋病毒流行病学，自然史和ARV治疗结果在亚洲有所不同。同时，ARV治疗正在迅速扩大。亚太艾滋病毒观察数据库旨在检查亚洲的艾​​滋病毒疾病自然史和治疗，并将结果与​​主要在澳大利亚的高加索人群进行比较，以为该地区的艾滋病毒疾病提供最佳护理和治疗。