Clinical Translation Core

临床翻译核心

基本信息

批准号：
10686082
负责人：
Andrea Lynne Gropman
金额：
$ 14.89万
依托单位：
CHILDREN'S RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-21 至 2026-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10686082
关键词：
Area Bioinformatics Biological Assay Biometry COVID-19 pandemic Cells Characteristics Child Clinical Clinical Research Clinical Trials Clinical and Translational Science Awards Cognitive deficits Collaborations Communities Companions Country Data Data Sources Development Diagnosis Dimensions Disease Disease Progression District of Columbia E-learning Epidemiology Evaluation Friends Future Genetic Variation Genomics Genotype Goals Health Technology Healthcare Hospitals Human Incubators Individual Informatics Infrastructure Institution Intellectual and Developmental Disabilities Research Centers Intellectual functioning disability Intervention Studies Knowledge Knowledge acquisition Machine Learning Managed Care Mentors Methods Microscopy National Center for Advancing Translational Sciences Neuropsychology Nursing Faculty Observational Study Online Systems Patient Recruitments Performance Phenotype Population Heterogeneity Practice Guidelines Process Publications Rare Diseases Registries Reporting Research Research Design Research Personnel Resources Sampling Studies Science Sensory Services Special Education Structure Technology Transfer Testing Tissues Training Translational Research Translations Vulnerable Populations Washington Work animal imaging autism spectrum disorder bench-to-bedside translation biobank biomarker development clinical practice clinical translation commercialization complex data cost effective data lake data mining data warehouse design digital health digital platform digital tool ethnic diversity experience human imaging innovation interest motor deficit neurobehavioral neuroimaging open data patient advocacy group phenomics programs racial diversity recruit research study response skills social media telehealth text searching tool web site

项目摘要

Project Summary The overall goal of the Clinical Translational Core (CTC) is to efficiently and effectively move basic and applied intellectual and developmental disability research (IDDR) findings into human clinical studies and ultimately clinical practice. The CTC is designed to serve as a “one-stop- shop” for IDD investigators, providing assistance and services either directly or in collaboration with other institutional resources (especially the Clinical and Translational Science Award (CTSA) program) at each stage of the clinical and translational research (CTR) spectrum at CNH, GW, GU and HU. This includes deep phenotyping, recruitment, performance, analysis, implementation, commercialization and dissemination. The proposed CTC will be coordinated by an administrative structure that is cost effective and provides specific infrastructure supports for DC-IDDR investigators and their teams. The direct functions of the CTC will include: 1) data mining of large real-world evidence data sources (informatics); 2) patient recruitment and study performance across multiple venues; 3) consultative support in biostatistics/informatics for planning, designing, and analyzing IDDR studies; 4) connection and collaboration with other IDDRC cores for deep phenotyping/genotyping and bio banking, and 5) training and dissemination through a web based investigator toolkit. The specific aims are: 1) To build a phenomics framework with a digital platform that integrates clinical and 'omics' data and a companion biorepository; 2) To employ a multi-dimensional strategy to enhance participant recruitment and study implementation/performance; 3) To provide IDDR-relevant study design, biostatistical and informatics support; and 4)To develop an IDDR investigator toolkit.

项目概要临床转化核心 (CTC) 的总体目标是高效、有效地推动人类基础和应用智力与发育障碍研究 (IDDR) 的发现 CTC 旨在充当“一站式”临床研究和最终临床实践。为 IDD 调查员提供“商店”，直接或合作提供帮助和服务与其他机构资源（特别是临床和转化科学奖（CTSA）计划）在临床和转化研究（CTR）范围的每个阶段 CNH、GW、GU 和 HU，这包括深度表型分析、招募、性能、分析、将协调拟议的 CTC 的实施、商业化和传播。通过具有成本效益并提供特定基础设施支持的管理结构对于 DC-IDDR 调查人员及其团队而言，CTC 的直接职能包括： 1) 数据。挖掘大量现实世界证据数据源（信息学）；2）患者招募和研究；跨多个场所的表现；3）生物统计/信息学方面的咨询支持规划、设计、分析 IDDR 研究；4) 与他人的联系和协作；用于深度表型/基因分型和生物库的 IDDRC 核心，以及 5) 培训和通过基于网络的调查员工具包进行传播，具体目标是： 1) 建立一个表型组学框架与数字平台集成了临床和“组学”数据以及 2）采用多维策略来增强参与者招募和研究实施/绩效；3) 提供 IDDR 相关研究设计，生物统计和信息学支持；以及 4) 开发 IDDR 研究人员工具包。