NUEROBIOLOGY OF INCREASED VULNEABILITY TO SOCIAL STRESSORS DURING ADOLESCENCE

青少年时期对社会压力的脆弱性增加的神经生物学

• 批准号: 7958271
• 负责人: Mark E Wilson
• 金额: $ 5.48万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7958271
• 关键词: Adolescence; Affect; Animal Testing; Animals; Behavioral Genetics; Brain; Complex; Computer Retrieval of Information on Scientific Projects Database; Development; Devices; Emotional; Feedback; Female; Funding; Genes; Genetic Polymorphism; Genotype; Glucocorticoids; Grant; Institution; Macaca mulatta; Measures; Mental disorders; Modeling; Positron-Emission Tomography; Primates; Proteins; Psychosocial Stress; Recruitment Activity; Research; Research Personnel; Resources; Serotonin; Social status; Source; Testing; United States National Institutes of Health; cohort; critical period; design; dexamethasone suppression test; neuroimaging; neurotransmission; receptor; reproductive; social; social group; stressor; uptake

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Using a rhesus monkey model, this project is designed to provide a better understanding of how psychosocial stress, imposed by social subordination, affects brain maturations and emotional development in females and whether this is influenced by polymorphisms in the gene that encodes the serotonin re-uptake transporter (5HTT), a protein essential for normal serotonin neurotransmission and emotionality. In this initial of the project, the first cohort of animals were recruited. These animals are embedded in large social groups at the Field Station and are distributed throughout the social status hierarchy of each group. In addition, 19 animals have the l/l 5HTT genotype and 20 animals have the l/s or s/s 5HTT genotype. Studies began this year included a dexamethasone suppression test to assess glucocorticoid negative feedback; measures of activity using a device (Actical) worn by the animal; tests of emotionality using the approach/avoidance test; and neuroimaging of the serotonin (5HT) 1A receptor using PET. These studies will elucidate the complex interplay between behavior, genetics, and reproductive maturation, providing a comprehensive understanding of how adolescence represents a critical period for the emergence of psychiatric disorders.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该项目使用恒河猴模型，旨在更好地了解社会从属带来的社会心理压力如何影响女性的大脑成熟和情绪发展，以及这是否受到编码血清素再摄取的基因多态性的影响转运蛋白 (5HTT)，一种对正常血清素神经传递和情绪至关重要的蛋白质。 在该项目的最初阶段，招募了第一批动物。 这些动物融入野外站的大型社会群体中，并分布在每个群体的社会地位等级中。 此外，19只动物具有l/l 5HTT基因型，20只动物具有l/s或s/s 5HTT基因型。 今年开始的研究包括评估糖皮质激素负反馈的地塞米松抑制试验；使用动物佩戴的设备（实际）测量活动；使用接近/回避测试进行情绪测试；以及使用 PET 对血清素 (5HT) 1A 受体进行神经成像。 这些研究将阐明行为、遗传学和生殖成熟之间复杂的相互作用，从而全面了解青春期如何代表精神疾病出现的关键时期。