ENDOMETRIOSIS IN RHESUS MACAQUES

恒河猴子宫内膜异位症

• 批准号: 7958748
• 负责人: Stephen B. Kennedy
• 金额: $ 4.68万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7958748
• 关键词: Affect; Age; Aging; Animal Model; Animals; Archives; Clinical; Computer Retrieval of Information on Scientific Projects Database; DNA; Environmental Risk Factor; Evaluation; Female; Fresh Tissue; Funding; Genetic Predisposition to Disease; Grant; Institution; Location; Macaca mulatta; Menstrual cycle; Mothers; Nuclear Family; Online Systems; Prevalence; Primates; Recurrence; Reporting; Research; Research Personnel; Resources; Risk; Services; Siblings; Source; Surveys; Tissue Sample; United States National Institutes of Health; Wisconsin; endometriosis; genetic pedigree; genome wide association study; nonhuman primate; segregation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To investigate the prevalence and familial aggregation of endometriosis in rhesus macaques. Endometriosis occurs in several non-human primate species that have menstrual cycles. Between 1978 and 2002, we identified 144 rhesus macaques with endometriosis. We established a large multigenerational pedigree and nine nuclear families comprising 1,602 females. Prevalence of endometriosis increased with age. Familial aggregation of endometriosis was strongly suggested by a significantly higher average kinship coefficient among affected animals compared with those unaffected. We saw a higher recurrence risk for full siblings when compared to maternal half siblings and paternal half sibs. The segregation ratio among affected mothers was not significantly higher compared with unaffected mothers. The results support familial aggregation of endometriosis in rhesus macaques and indicate that this is a promising animal model for investigating the mode of inheritance, the location of potential genetic susceptibility loci and the influence of environmental factors. Evaluation of pedigree and genetic information is continuing. In the current report period, we isolated DNA from archived and fresh tissue samples for a genome-wide association study. The project is currently expanding to include additional clinical collaborators through our CTSA (see SPID 0447) and a web-based survey of the prevalence of endometrisosis in the colonies of the other NPRCs. This research used WNPRC Animal Services and Aging Resources. Funded by a supplement to RR000167.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 目的：研究子宫猕猴中子宫内膜异位症的患病率和家族聚集。 子宫内膜异位症发生在具有月经周期的几种非人类灵长类动物中。在1978年至2002年之间，我们确定了144颗猕猴患有子宫内膜异位症。我们建立了一个大型的多代血统和九个核心家庭，其中包括1,602名女性。子宫内膜异位症的患病率随着年龄的增长而增加。与未受影响的动物相比，受影响的动物的平均亲属系数明显更高的平均亲属系数强烈建议子宫内膜异位症的家族性聚集。与母亲的半兄弟姐妹和父亲的半个同胞相比，我们看到完整兄弟姐妹的复发风险更高。与未受影响的母亲相比，受影响母亲的隔离比没有明显更高。结果支持猕猴中子宫内膜异位症的家族聚集，并表明这是一个有前途的动物模型，用于研究遗传模式，潜在的遗传易感基因座的位置以及环境因素的影响。谱系和遗传信息的评估仍在继续。在当前的报告期间，我们从存档和新鲜组织样品中分离了DNA，以进行全基因组关联研究。 该项目目前正在扩展，包括通过我们的CTSA（请参阅SPID 0447）以及基于网络的其他NPRC菌落中子宫内膜异位症患病率的调查。 这项研究使用了WNPRC动物服务和老化资源。由RR000167补充剂资助。