Enhancement of an Artificial Lung for Ambulatory Respiratory Support

增强人工肺的动态呼吸支持

基本信息

批准号：
10683395
负责人：
Bartley P GriffIth
金额：
$ 74.43万
依托单位：
UNIVERSITY OF MARYLAND BALTIMORE
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-07-05 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10683395
关键词：
Acute Acute Disease Acute respiratory failure Air Algorithms Animal Experiments Animals Area Atmosphere Biocompatible Materials Biological Blood Carbon Dioxide Chronic Chronic Disease Destinations Development Devices Electromagnetics Electronics Evaluation Excision Exercise Extracorporeal Membrane Oxygenation Fuzzy Logic Gases Goals Healthcare Hemolysis Hospitals Hour In Vitro Injury Legal patent Liquid substance Lung Lung diseases Measurement Mechanical ventilation Mechanics Membrane National Heart, Lung, and Blood Institute Oxygen Oxyhemoglobin Patients Performance Physiological Pump Pump lung Qualifying Safety Self-Help Devices Software Validation Source Sterilization Surface System Technology Testing Toxic effect Transplantation Validation Venous Weight artificial lung biomaterial compatibility commercialization design exhaust healing improved in vitro testing in vivo light weight manufacturability manufacturing process manufacturing test multidisciplinary new technology novel portability pre-clinical regenerative therapy respiratory respiratory assist response sheep model sterility testing technology platform

项目摘要

Acute and chronic end-stage lung diseases (ESLD) are increasing healthcare problems. Currently, when mechanical ventilation fails only extracorporeal membrane oxygenation (ECMO) with components designed and qualified for a few hours is available. Current ECMO systems are often associated with serious complications and generally are restricted to bedside use. A wearable, biocompatible integrated pump-lung would offer significant advantages to patients over existing options. Such a device would pose a prolonged ambulatory platform for natural lung healing from acute injury, a bridge to transplant or destination therapy, or for novel lung regenerative therapies. With support from the NHLBI, we have made remarkable progress in development of a wearable artificial pump-lung system (APLS) for ambulatory respiratory support. The goal of this renewal application is to develop a new class of gas exchange device with adaptive physiologic control for a wearable artificial lung system. We propose to develop unique strategies to reduce the sizes of gas exchanger devices and associated drive consoles and to provide adaptive respiratory support to ambulating ECMO patients. Three specific aims of the proposal are: (1) to develop a small-sized and multifunctional membrane respiratory assist device (MRAD) for ECMO therapy in the ambulatory setting. The novel MRAD will include a dual chamber gas exchanger (DCGE) for blood and gas flows with an integrated centrifugal pump; (2) to develop a lightweight console for the MRAD with auto-adaptive control based on the gas exchange demand of an ambulating patient. The portable console will be less than 20 lbs and can be placed into a backpack; and (3) to conduct in-vitro regulatory qualification tests and chronic (30-day) in-vivo animal experiments to assess the long-term function, biocompatibility, and durability of the MRAD and its biologic effect on the animal. The efficiency of the new gas exchange device will reduce its size and its console by near 30%. The reduced console size and weight will reduce its burden to the user and will permit its configuration into a backpack design as well as a small roller case. Completion of aims will redefine the technology appropriate for broadened use of ambulatory ECMO and for its out-of-hospital use.

急性和慢性终末期肺病（ESLD）正在加剧医疗保健问题。目前，当机械通气仅对采用设计组件的体外膜肺氧合 (ECMO) 失败并且合格的几个小时是可用的。当前的 ECMO 系统通常与严重的并发症，并且通常仅限于床边使用。可穿戴、生物相容性集成泵肺与现有的选择相比，将为患者提供显着的优势。这种装置会造成长时间的用于急性损伤肺部自然愈合的流动平台，移植或目的地治疗的桥梁，或用于新型肺再生疗法。在 NHLBI 的支持下，我们在以下方面取得了显着进展：开发用于动态呼吸支持的可穿戴人工泵肺系统（APLS）。目标是这项更新应用旨在开发一种具有自适应生理控制功能的新型气体交换装置可穿戴式人工肺系统。我们建议制定独特的策略来减小气体交换设备和相关驱动器的尺寸控制台并为移动 ECMO 患者提供适应性呼吸支持。三大具体目标提案是：（1）开发小型多功能膜式呼吸辅助装置（MRAD）门诊环境下的 ECMO 治疗。新型 MRAD 将包括双室气体交换器 (DCGE) 使用集成离心泵进行血液和气体流动； (2) 为MRAD开发轻量级控制台根据移动患者的气体交换需求进行自适应控制。便携式控制台重量小于 20 磅，可放入背包中； (3) 进行体外监管资质测试和长期（30天）体内动物实验，以评估长期功能、生物相容性和 MRAD 的耐久性及其对动物的生物学影响。新型气体交换装置的效率将使其尺寸及其控制台缩小近30%。减少的控制台的尺寸和重量将减轻用户的负担，并允许将其配置到背包中设计以及一个小滚轮箱。目标的完成将重新定义适合的技术扩大了门诊 ECMO 的使用及其院外使用。

项目成果

期刊论文数量（15）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Increased phagocytosis capacity of circulating neutrophils in patients on continuous flow ventricular assist device support.

在连续流心室辅助装置支持下患者循环中性粒细胞的吞噬能力增加。

DOI：
发表时间：
2023-12-22
期刊：
影响因子：
2.4
作者：
Awad, Morcos A;Sun, Wenji;Han, Dong;Griffith, Bartley P;Wu, Zhongjun J
通讯作者：
Wu, Zhongjun J

The impact of shear stress on device-induced platelet hemostatic dysfunction relevant to thrombosis and bleeding in mechanically assisted circulation.

剪切应力对与机械辅助循环中血栓形成和出血相关的装置引起的血小板止血功能障碍的影响。

DOI：
发表时间：
2020-05
期刊：
影响因子：
2.4
作者：
Chen, Zengsheng;Zhang, Jiafeng;Li, Tieluo;Tran, Douglas;Griffith, Bartley P;Wu, Zhongjun J
通讯作者：
Wu, Zhongjun J

Device-Induced Hemostatic Disorders in Mechanically Assisted Circulation.

机械辅助循环中装置引起的止血障碍。

DOI：
发表时间：
2021-01
期刊：
影响因子：
0
作者：
Wang, Shigang;Griffith, Bartley P;Wu, Zhongjun J
通讯作者：
Wu, Zhongjun J

Evaluation of an autoregulatory ECMO system for total respiratory support in an acute ovine model.

在急性绵羊模型中评估自动调节 ECMO 系统的全面呼吸支持。

DOI：
发表时间：
2020-05
期刊：
影响因子：
2.4
作者：
Conway, Robert G;Berk, Zachary B;Zhang, Jiafeng;Li, Tieluo;Tran, Douglas;Wu, Zhongjun J;Griffith, Bartley P
通讯作者：
Griffith, Bartley P

Impact of high mechanical shear stress and oxygenator membrane surface on blood damage relevant to thrombosis and bleeding in a pediatric ECMO circuit.

高机械剪切应力和氧合器膜表面对儿科 ECMO 回路中与血栓形成和出血相关的血液损伤的影响。

DOI：
发表时间：
2020-07
期刊：
影响因子：
2.4
作者：
Sun, Wenji;Wang, Shigang;Chen, Zengsheng;Zhang, Jiafeng;Li, Tieluo;Arias, Katherin;Griffith, Bartley P;Wu, Zhongjun J
通讯作者：
Wu, Zhongjun J