Yoga for women with breast cancer undergoing radiotherapy

适合接受放射治疗的乳腺癌女性的瑜伽

• 批准号: 7888532
• 负责人: Lorenzo Cohen
• 金额: $ 91.37万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7888532
• 关键词: Acute; Address; Adherence; Adjuvant; Adverse effects; Aftercare; Anxiety; Appointment; Attention; Behavior; Breast Cancer Treatment; Breathing; Cancer Patient; Cessation of life; Cognitive; Combined Modality Therapy; Control Groups; Cost Effectiveness Analysis; Counseling; Diagnosis; Disease Progression; Distress; Emotional; Fatigue; Fright; Future; Health; Health Care Costs; Home environment; Hospitals; Hydrocortisone; Individual; Intervention; Life; Lung; Maintenance; Malignant Neoplasms; Measures; Mediating; Meditation; Mental Depression; Mental Health; Morbidity - disease rate; Movement; Operative Surgical Procedures; Outcome; Participant; Patients; Periodicity; Phase III Clinical Trials; Physical Function; Physical activity; Physiological; Posture; Process; Productivity; Psychological Side Effects; Quality of life; Radiation; Radiation therapy; Randomized; Recovery; Recurrence; Relaxation; Relaxation Techniques; Reporting; Research; Schedule; Science; Skin; Sleep disturbances; Social support; Source; Spirituality; Stress; Stretching; Symptoms; Techniques; Telephone; Time; Trauma; Treatment Efficacy; Treatment Protocols; Woman; Work; Yoga; arm; behavior change; body-mind; cancer therapy; chemotherapy; coping; cost effectiveness; economic outcome; experience; follow-up; group intervention; improved; indexing; intervention effect; malignant breast neoplasm; preference; programs; psychologic; public health relevance; social; social model; standard of care; stress management; stressor; treatment as usual; treatment effect; treatment planning; visual imagery

DESCRIPTION (provided by applicant): Cancer and its treatment are associated with considerable distress, impaired quality of life (QOL), poor mental health, and reduced physical function. This is particularly true for women with breast cancer who receive multimodal treatment over an extended period of time. Many women undergo surgery and chemotherapy, which are often followed by radiotherapy. It is important to develop programs that can help ameliorate the treatment-related morbidity that accumulates over time for women with breast cancer. Furthermore, given the stressful time demands posed by radiotherapy treatment (patients typically receive treatment 5-days per week for 6 weeks) it is crucial that programs be easily incorporated into the treatment schedule. Research suggests that stress-reduction programs tailored to the cancer setting may help patients cope with the acute effects of treatment and improve QOL after treatment. Yoga, an ancient Indian science, incorporates stress-reduction techniques including regulated breathing, visual imagery, meditation, and various gentle stretching postures. Yoga may be particularly useful for women with breast cancer after surgery and while undergoing radiation treatment because of the stress management and relaxation techniques and the gentle stretching that should facilitate recovery. Preliminary studies found yoga is useful for women with breast cancer undergoing radiotherapy. Integrating a yoga program into the treatment regimen of women undergoing radiotherapy for breast cancer makes participation in the program easy and compliance has been high. We will determine the efficacy of implementing a yoga program for patients with breast cancer as an adjuvant to their radiotherapy. Patients with breast cancer who are undergoing radiotherapy will be randomly assigned to one of three groups: a yoga group, a stretching/relaxation group, or a waitlist control group. Participants in the two intervention groups will attend sessions 3 days/week throughout their 6-week radiotherapy schedule. Measures will be obtained prior to randomization, midway through radiotherapy, during the last week of radiotherapy, and 1 and 3, 6 and 12 months after the end of radiotherapy. We will examine indices of QOL, fatigue, sleep disturbances, mental health, cost- effectiveness analysis, work and/or home productivity, and cortisol rhythmicity. We hypothesize that the yoga program will help facilitate recovery and alleviate the physiological and psychological side effects experienced by patients who are currently receiving radiotherapy. PUBLIC HEALTH RELEVANCE: The proposed study will examine efficacy of incorporating a Yoga program alongside radiotherapy for women with breast cancer. If we find that the Yoga program facilitates recovery and alleviates the psychological and physiological side effects experienced by women undergoing radiotherapy, then this type of program can be incorporated into the treatment plan as the standard of care. Future research could examine individual preferences for different types of mind-body or physical activity programs incorporated in the treatment plan to help with recovery.

描述（由申请人提供）： 癌症及其治疗与相当大的困扰，生活质量受损（QOL），精神健康不良以及身体机能降低有关。对于长时间接受多模式治疗的乳腺癌女性而言，这尤其如此。许多妇女接受手术和化学疗法，通常进行放疗。重要的是要开发可以帮助改善与治疗相关的发病率的计划，从而使乳腺癌女性随着时间的流逝而积累。此外，鉴于放射治疗所提出的压力时间（通常每周5天治疗6周）提出了压力时间，因此很容易将程序轻松纳入治疗时间表至关重要。研究表明，针对癌症设置的压力减少计划可以帮助患者应对治疗的急性影响并改善治疗后的QOL。瑜伽是一门古老的印度科学，结合了减少压力的技术，包括受调节的呼吸，视觉图像，冥想和各种柔和的伸展姿势。瑜伽在手术后对乳腺癌女性特别有用，并且由于压力管理和放松技术以及应促进康复的柔和拉伸而接受放射治疗的同时。初步研究发现，瑜伽对接受放疗的乳腺癌女性有用。将瑜伽计划整合到接受乳腺癌放疗的妇女的治疗方案中，使参与该计划很容易，并且合规性很高。我们将确定针对乳腺癌患者作为放射治疗的辅助患者实施瑜伽计划的功效。正在接受放疗的乳腺癌患者将随机分配给三组之一：瑜伽组，伸展/放松组或候补名单对照组。两个干预小组的参与者将在6周的放射疗法计划中参加3天/周的课程。在放射疗法的最后一周，放疗的最后一周以及放射疗法结束后的1和3、6和12个月，将在随机分组之前，进行放疗。我们将研究QOL，疲劳，睡眠障碍，心理健康，成本效益分析，工作和/或家庭生产力以及皮质醇节奏的指标。我们假设瑜伽计划将有助于促进康复，并减轻目前正在接受放疗的患者所遇到的生理和心理副作用。 公共卫生相关性： 拟议的研究将检查将瑜伽计划与放射治疗同时纳入乳腺癌女性的功效。如果我们发现瑜伽计划有助于康复并减轻接受放射疗法的妇女所经历的心理和生理副作用，那么可以将这种类型的程序纳入治疗计划中。未来的研究可以检查针对治疗计划中纳入不同类型的思维体或体育活动计划的个人偏好，以帮助康复。