Center for Cancer Signaling Networks

癌症信号网络中心

• 批准号: 8251146
• 负责人: Walter J Atwood
• 金额: $ 109.13万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-15 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8251146
• 关键词: Bioinformatics; Biological Preservation; Cancer Center; Centers of Research Excellence; Collaborations; Communities; Computational Molecular Biology; Computers; Core Facility; Cost Sharing; Cryopreservation; Derivation procedure; Doctor of Philosophy; Embryo; Ensure; Faculty; Fees; Fostering; Funding; Gene Targeting; Genomics; Goals; Grant; Image; Individual; Instruction; Link; Malignant Neoplasms; Mentors; Mus; Pilot Projects; Positioning Attribute; Production; Request for Applications; Research; Research Infrastructure; Research Personnel; Resources; Rhode Island; Running; Services; Signal Transduction; Solid; Transgenic Mice; Transgenic Mouse Facility; Transgenic Organisms; Translating; Universities; Work; base; career; cost effective; cryogenics; improved; meetings; programs; tool; web site

The major goal of our type III transitional COBRE is to provide state of the art genomic and transgenic core services to the Brown University community and affiliated centers in the Northeast while preparing to transition to independent suport in the next five years. The scientific theme of the Center developed with type II COBRE support was cancer signaling networks. This general scientific theme will be continued but we as a center are poised to provide the research infrastructure for a wider range of scientific projects than were supported initially in the type II COBRE. The pilot project mechanism associated with the type III COBRE will be used to nucleate collaborative efforts by groups of faculty focusing on significant scientific problems that can immediately translate into multi-PI and/or program project applications. The research cores originally proposed were Mouse Transgenics, Imaging, Genomics and Bioinformatics. The first three carried over from the type I COBRE while the latter was established as a new core facility. The Bioinformatics core was only briefly supported by the type II COBRE as it evolved into an independent center (Center for Computational Molecular Biology). The Imaging core was also graduated from COBRE support and now functions as an independent facility. The imaging core has grown exponentially and is a major resource for investigators at Brown and in the state. We have a track record of using COBRE resources to develop solid research cores whose scientific focus allows them to achieve independence from this mechanism. Our remaining two cores for which we are requesting support are quickly becoming more heavily relied on by the scientific community here in Rhode Island. We will continue to improve these cores to the point where they can be independently supported by a combination of user fees, individual and program-type grant support, and University cost-sharing when needed.

我们III型过渡性鞋底的主要目标是提供最先进的基因组和转基因核心 为布朗大学社区和东北的附属中心提供服务，同时准备 未来五年过渡到独立Suport。该中心的科学主题与 II型毛线支持是癌症信号网络。这个一般科学主题将继续 作为一个中心，我们准备为更广泛的科学项目提供研究基础设施 最初在II型毛绒中得到支持。与III型相关的试点项目机制 Cobre将用于将关注重大科学的教职员工组成的合作努力。 可以立即转化为多PI和/或程序项目应用程序的问题。研究 最初提出的核心是小鼠转基因，成像，基因组学和生物信息学。前三个 在后者成为新的核心设施时，从I型毛绒中延续了。这 生物信息学核心仅由II型毛绒短暂支持，因为它演变成独立的中心 （计算分子生物学中心）。成像芯也从毛线支撑毕业 现在是独立设施。成像核心成倍增长，是主要的 布朗和州调查员的资源。我们有使用毛关系来记录 开发扎实的研究核心，其科学重点使他们能够实现独立性 机制。我们剩下的两个我们要求支持的核心正在迅速变得越来越多 罗德岛州的科学界严重依赖。我们将继续改善这些核心 到可以通过用户费用，个人和 程序类型的赠款支持和大学成本共享。