University of Illinois at Chicago KPMP CKD Recruitment Site

伊利诺伊大学芝加哥分校 KPMP CKD 招聘网站

基本信息

批准号：
10701830
负责人：
JAMES P. LASH
金额：
$ 45万
依托单位：
UNIVERSITY OF ILLINOIS AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-15 至 2027-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10701830
关键词：
Address Adopted Adult Affect Algorithms American Atlases Benefits and Risks Bioethics Bioethics Consultants Biometry Black race Characteristics Chicago Chronic Kidney Failure Chronic Kidney Insufficiency Classification Clinic Visits Clinical Cohort Studies Collaborations Communities Coupling Data Data Collection Development Diabetic Nephropathy Diagnosis Disease Disease Progression Economics Electronic Health Record Eligibility Determination Enrollment Ensure Ethics Evaluation Federally Qualified Health Center Glomerular Filtration Rate Goals Health Health Sciences Healthcare Systems Heterogeneity Hispanic Illinois Individual Infrastructure Interventional radiology Interview Kidney Kidney Diseases Letters Link Longitudinal Studies Malignant Neoplasms Measures Methods Mission National Institute of Diabetes and Digestive and Kidney Diseases Neighborhoods Nephrology Not Hispanic or Latino Ontology Outcome Participant Pathology Patients Persons Phenotype Play Population Heterogeneity Prevention Proteinuria Protocols documentation Public Health Reporting Research Research Personnel Rheumatism Role Site Structure System Telephone Time Underrepresented Minority United States Universities Visit Work built environment career clinical center clinical phenotype cohort disease heterogeneity disorder subtype ethnic minority population experience follow-up improved inclusion criteria insight interest kidney biopsy meetings molecular phenotype multidisciplinary patient engagement patient oriented patient population patient portal personalized medicine phenotypic data precision medicine primary care provider racial minority population recruit retention rate social social health determinants working group

项目摘要

Chronic kidney disease (CKD) is a major public health problem in the United States that affects 37 million Americans and disproportionately burdens racial and ethnic minority populations. Advances in personalized medicine approaches for patients with CKD lag behind advances in other fields. Current approaches to classifying CKD do not provide granular insight into the underlying mechanisms that contribute to the heterogeneity of the disease. To address this gap, NIDDK established the Kidney Precision Medicine Project (KPMP) in 2016 with the overarching goal of using deep molecular phenotypes of kidney biopsies, along with longitudinal clinical phenotypic data to develop new disease ontologies and treatments for kidney disease. This proposal for a University of Illinois at Chicago (UIC) KPMP CKD Recruitment Site brings together a diverse multidisciplinary team of experienced investigators with expertise in nephrology, renal pathology, interventional radiology, bioethics, social determinants of health, and biostatistics. Our team has a successful track record in recruiting and retaining large and diverse populations of patients with CKD in long-term studies. This proposal has three overarching goals: 1) Utilize our well-established and successful recruitment strategies to enroll 100 participants (50% non-Hispanic Black, 30% Hispanic) from the University of Illinois Health Science System and a large affiliated federally qualified health center to undergo high-quality research kidney biopsies, conforming to the highest ethical, research and clinical standards; 2) Leverage the infrastructure of the UIC Chronic Renal Insufficiency Cohort (CRIC) Study Clinical Center to enroll 50 eligible CRIC participants into KPMP, providing an unprecedented opportunity to link data from this deeply phenotyped cohort with KPMP kidney biopsy measures; and 3) Implement a systematic assessment of neighborhood-level measures of social determinants of health which will advance the overall mission of KPMP to better characterize disease subgroups. We will use an established real-time electronic health record-based reporting system to identify eligible individuals in the two health care systems and then engage potential participants in an open discussion of the risks and benefits of a research kidney biopsy. Additionally, we will utilize patient-centered strategies to maintain long- term patient engagement and achieve high rates of retention with the guidance of a local Community Advisory Board composed of key stakeholders (i.e., patients, a caretaker, and a primary care provider). Leveraging our expertise and experience working with NIDDK U01 cooperative projects, we will rapidly and effectively implement the KPMP protocol, work collaboratively with the consortium, and will make substantial contributions to the long-term scientific mission of KPMP to develop precision medicine-based approaches for treating kidney disease.

慢性肾病 (CKD) 是美国的一个主要公共卫生问题，影响着 3700 万人美国人给种族和少数民族人口带来了不成比例的负担。个性化方面的进步慢性肾病患者的医学方法落后于其他领域的进步。目前的方法对 CKD 进行分类并不能深入了解导致 CKD 发生的潜在机制疾病的异质性。为了弥补这一差距，NIDDK 建立了肾脏精准医学项目 (KPMP) 于 2016 年，其总体目标是利用肾脏活检的深层分子表型，以及纵向临床表型数据，用于开发新的疾病本体论和肾脏疾病的治疗方法。这伊利诺伊大学芝加哥分校 (UIC) KPMP CKD 招聘网站的提案汇聚了多元化的人才由经验丰富的研究人员组成的多学科团队，具有肾脏病学、肾脏病理学、介入治疗方面的专业知识放射学、生物伦理学、健康的社会决定因素和生物统计学。我们的团队在以下方面拥有成功的记录在长期研究中招募和保留大量不同的 CKD 患者。这个提议拥有三个总体目标：1) 利用我们完善且成功的招聘策略来招收 100 名来自伊利诺伊大学健康科学系统的参与者（50% 非西班牙裔黑人，30% 西班牙裔）大型附属联邦合格健康中心进行高质量研究肾活检，符合遵守最高的道德、研究和临床标准； 2) 利用UIC慢性肾病的基础设施不足队列 (CRIC) 研究临床中心将招募 50 名符合条件的 CRIC 参与者加入 KPMP，提供将这个深度表型队列的数据与 KPMP 肾活检联系起来的前所未有的机会措施； 3) 对社区层面的社会决定因素指标进行系统评估这将推动 KPMP 更好地描述疾病亚组特征的总体使命。我们将使用已建立的基于电子健康记录的实时报告系统来识别符合资格的个人两个医疗保健系统，然后让潜在参与者就风险和风险进行公开讨论研究性肾活检的好处。此外，我们将利用以患者为中心的策略来维持长期在当地社区咨询的指导下，长期患者参与并实现高保留率董事会由主要利益相关者（即患者、看护者和初级保健提供者）组成。利用我们的与NIDDK U01合作项目合作的专业知识和经验，我们将快速有效地落实KPMP协议，与财团协同工作，将做出实质性贡献 KPMP 的长期科学使命是开发基于精准医学的治疗方法肾脏疾病。