Multi-site Feasibility of Compassion Meditation for Veterans with PTSD

对患有创伤后应激障碍 (PTSD) 的退伍军人进行同情冥想的多地点可行性

• 批准号: 10681296
• 负责人: Ariel J Lang
• 金额: $ 59.53万
• 依托单位: VETERANS MEDICAL RESEARCH FDN/SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10681296
• 关键词: Address; Area; Assessment tool; Behavioral; California; Caring; Clinical; Clinical Trials; Cognitive; Compassion; Complement; Country; Data; Development; Enrollment; Evidence based treatment; Fostering; Future; Glean; Goals; Health; Humanities; Impairment; Individual; Intervention; Investigation; Laboratories; Lead; Link; Manuals; Measures; Mediating; Meditation; Methodology; Military Personnel; Monitor; National Center for Complementary and Integrative Health; Outcome; Patient Self-Report; Personal Satisfaction; Phase; Population; Post-Traumatic Stress Disorders; Preparation; Procedures; Process; Protocols documentation; Randomized; Randomized, Controlled Trials; Recovery; Relaxation; Research; Role; Sampling; Site; Stress; Symptoms; Training; Translating; Veterans; Work; acceptability and feasibility; clinical effect; coping; efficacy trial; interest; multimodality; participant retention; patient response; pilot test; positive emotional state; preference; psychologic; psychosocial; randomized trial; recruit; regional difference; resilience; social; tool; treatment effect

PROJECT SUMMARY/ABSTRACT Posttraumatic stress disorder (PTSD) is a common health concern among Veterans. Although empirically-supported approaches are widely available, engagement rates are low and partial/non response is common. There has been considerable interest in the role of complementary and alternative interventions for PTSD, but little research is available to guide decisions about care. Compassion meditation (CM), a contemplative practice that is intended to foster connectedness with others, shows promise for the treatment of PTSD in Veterans. In healthy populations, CM fosters positive emotion and social connectedness, both of which are known to enhance coping and resilience in the face of extreme stress. Based on this theoretical rationale, we recently completed a two-phase proof of concept trial of CM for Veterans with PTSD. The first phase employed qualitative and quantitative procedures to iteratively refine an existing CM protocol, CBCT® (Cognitively-Based Compassion Training), for Veterans with PTSD. The second phase utilized a pilot randomized controlled trial to establish the feasibility and acceptability of a randomized trial of CM for Veterans with PTSD and to examine potential clinical impact. On the basis of promising results, the proposed project will evaluate the feasibility of a future multi-site efficacy trial of CM for PTSD. Although our prior work is an encouraging first step, key questions remain. First, our data come from a single site in Southern California. It is possible that there are regional differences in the acceptability of CM, so we plan to examine the feasibility of recruiting and retaining Veterans residing in another area as well as confirming the acceptability of the approach to a more diverse sample. Second, our previous trial relied on a single therapist, who was actively engaged in the development process. It is important to demonstrate that others can be trained to deliver the approach with fidelity and to have some confidence that our results are attributable to the protocol rather than to an individual. Finally, in the interest of ultimately understanding the way in which these interventions lead to symptom change, we will continue to refine our assessment strategy, including adding behavioral methodologies to augment what can be gleaned from self-report measures. If successful, this project will lay the necessary groundwork for an efficacy trial of CM, which ultimately could provide an additional evidence-based treatment option for Veterans with PTSD.

项目概要/摘要 创伤后应激障碍（PTSD）是退伍军人中常见的健康问题。 经验支持的方法广泛可用，参与率低，并且部分/无响应 人们对补充性和替代性干预措施的作用非常感兴趣。 创伤后应激障碍（PTSD），但很少有研究可以指导有关同情冥想（CM）的决策。 旨在促进与他人联系的冥想练习，显示出治疗以下疾病的希望 退伍军人的创伤后应激障碍 (PTSD) 在健康人群中，CM 可以培养积极情绪和社会联系。 根据这一理论，已知可以增强面对极端压力的应对能力和恢复力。 出于基本原理的考虑，我们最近完成了针对患有 PTSD 的退伍军人的 CM 概念验证试验，分为两个阶段。 该阶段采用定性和定量程序来迭代完善现有的 CM 协议 CBCT® （基于认知的同情心培训），针对患有创伤后应激障碍（PTSD）的退伍军人第二阶段采用了试点。 随机对照试验旨在确定退伍军人 CM 随机试验的可行性和可接受性 与 PTSD 并检查潜在的临床影响 基于有希望的结果，拟议的项目将 评估未来 CM 治疗 PTSD 多中心疗效试验的可行性。 尽管我们之前的工作是令人鼓舞的第一步，但关键问题仍然存在。首先，我们的数据来自于。 南加州的单个站点 CM 的可接受性可能存在地区差异，因此 我们计划研究招募和留住居住在另一个地区的退伍军人的可行性 其次，我们之前的试验依赖于更多样化的样本。 积极参与发展过程的单身治疗师很重要的是要证明这一点。 其他人可以接受培训，以忠实地提供该方法，并对我们的结果有一定的信心 最后，为了最终理解该协议。 这些干预措施导致症状改变的方式，我们将继续完善我们的评估策略， 包括添加行为方法来增强可以从自我报告措施中收集到的信息。 如果该项目取得成功，将为 CM 功效试验奠定必要的基础，最终可以 为患有创伤后应激障碍 (PTSD) 的退伍军人提供额外的循证治疗选择。