Vervet Research Colony as a Biomedical Resource

作为生物医学资源的黑长尾黑长尾猴研究群体

基本信息

批准号：
8089480
负责人：
Jay Ross Kaplan
金额：
$ 67.87万
依托单位：
WAKE FOREST UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-07-14 至 2015-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8089480
关键词：
3 year old Affect Age-Months Age-Years Aging Animal Model Animal Sources Animals Archives Autopsy Award Behavior Biocompatible Materials Biological Biology Biomedical Research Breeding Caribbean region Cell Line Centers for Disease Control and Prevention (U.S.)Cercopithecidae Cercopithecus pygerythrus Characteristics Chromosome Mapping Chronic Disease Clinical Collection Communicable Diseases Communities Community Outreach Country Data Databases Degenerative Disorder Development Dimensions Disease Ensure Etiology Evaluation Extramural Activities Faculty Female Foundations Funding Future Gene Expression Generations Genetic Genetic Variation Genomics Genotype Glucose Glycosylated Hemoglobin Goals Grant Gray unit of radiation dose Health Hereditary Disease Human Image Individual Infant Infectious Agent Information Systems Institutes Insulin Interleukin-6 Investigation Laboratory Animal Medicine Laboratory Animals Length Licensing Link Lipids Lipoproteins Listeriosis Macaca Macaca mulatta Measures Medicine Metabolic Metabolic Diseases Mission Modeling Monkeys National Center for Research Resources National Human Genome Research Institute Neonatal Nomograms Non-Insulin-Dependent Diabetes Mellitus Nucleic Acids Obesity Pan Genus Pan troglodytes Papio Papio hamadryas Pathology Perinatal mortality demographics Peripheral Phenotype Plasma Population Predisposition Primates Publications Quarantine Recording of previous events Research Research Design Research Infrastructure Research Personnel Research Training Resources Rewards Risk SIV Sales Sampling Scientist Screening procedure Series Shapes Shipping Ships Single Nucleotide Polymorphism Site Social status Structure Students System Temperament Testing Tissues Training Training Support Translating United States National Institutes of Health Universities Veterinarians Weight abortion biomedical resource brain metabolism catalyst clinical care comparative cost cytokine design fetal forest functional genomics genetic pedigree genome sequencing genome-wide indexing interest juvenile animal life history male meetings neurobehavioral neurogenetics neuropsychiatry next generation nonhuman primate novel novel strategies outreach program pathogen programs public health relevance repository skills tool trait vaccine evaluation vervet

项目摘要

DESCRIPTION (provided by applicant): This is a competing renewal requesting support for the pedigreed and genotyped Vervet Research Colony (VRC). The VRC is structured to provide NIH-funded researchers with the opportunity to conduct genetically informed studies of the chronic, degenerative, and infectious diseases comprising the majority of the human health burden. The VRC provides access to the complete pedigree for phenotyping or genetic mapping, to individual monkeys or groups that can be purchased for use on- or off-site, and to the extensive data and tissue repositories that have been derived from the VRC over the past 25 years. Such repositories not only provide preliminary data but are designed for novel hypothesis generation and testing. To encourage maximum use of the resource and associated repositories, the VRC faculty engage in a vigorous program of extramural recruitment of scientists and projects. The four specific aims are: 1) to maintain a pathogen- defined pedigree enabling NlH-supported researchers to conduct linkage and association studies in relation to biomedically relevant traits and to engage in longitudinal or short-term phenotypic investigations using the pedigree under controlled environmental and genetic conditions; 2) to provide animals for purchase by NlH-supported investigators, including options for on- or off-site use and pilot investigations; 3) to provide the VRC as a platform for training veterinarians and other professionals in the husbandry and clinical care of vervets; and 4) to enrich the resource by leveraging the integrated genetics and genomics platform to identify the biological mechanisms linking neurobehavioral (e.g., reward sensitivity) and cardiometabolic (e.g., obesity and its sequelae) phenotypes. Aim 4 is the research aim of the application and takes advantage of the complementary scientific skills of the UCLA and WFU investigators to enhance the value of the resource for novel, multi-system investigations with substantial translational relevance. The foregoing aims are designed to fulfill completely the characteristics required for an Animal Model and Biological Materials Resource Grant (P40). PUBLIC HEALTH RELEVANCE (provided by applicant): The vervet is a model of choice for neurogenetic studies, the development of cell-lines, vaccine testing, cardiometabolic investigations, and the investigation of simian immunodeficiency virus. The vervet also models many of the same diseases studied in other monkeys and is therefore an alternative biomedical species. Finally, it is anticipated that the vervet will have available the first genome wide, single nucleotide polymorphism resource available for any nonhuman primate.

描述（由申请人提供）：这是一个竞争的续订，要求对尚未养育和基因分型的Vervet Research Colony（VRC）提供支持。 VRC的结构是为NIH资助的研究人员提供机会，以对包括大多数人类健康负担的慢性，退化性和传染病进行遗传知情研究。 VRC为可以购买的单个猴子或可以在现场或现场购买的单个猴子或基团，以及在过去25年中从VRC衍生的广泛数据和组织存储库提供了对单个猴子或可以使用的单个猴子或群体的访问。这样的存储库不仅提供了初步数据，而且是为新的假设产生和测试而设计的。为了鼓励最大程度地利用资源和相关的存储库，VRC教师参与了一项庞大的科学家和项目的校外招聘计划。这四个具体目的是：1）维持病原体定义的血统，使NLH支持的研究人员能够进行与生物医学相关性状有关的联系和关联研究，并使用在受控的环境和遗传条件下使用谱系的纵向或短期表型研究； 2）为NLH支持的调查人员提供动物，包括现场使用或试点调查的选项； 3）为VRC提供培训兽医和其他专业人士的饲养和临床护理的平台； 4）通过利用综合遗传学和基因组学平台来识别与神经行为（例如奖励灵敏度）和心脏代谢（例如肥胖及其后遗症）相关的生物学机制来丰富资源。 AIM 4是应用的研究目的，并利用了UCLA和WFU研究人员的互补科学技能，以增强资源对具有实质性翻译相关性的新颖，多系统研究的价值。上述目标旨在完全实现动物模型和生物材料资源赠款（P40）所需的特征。公共卫生相关性（由申请人提供）：Vervet是神经遗传学研究的选择模型，细胞线的发展，疫苗测试，心脏代谢研究和邻虫免疫缺陷病毒的研究。这个虫子还模拟了其他猴子中研究的许多相同疾病，因此是一种替代的生物医学物种。最后，可以预料，这个vervet将获得第一个可用于任何非人类灵长类动物的基因组宽的单核苷酸多态性资源。