Vervet Research Colony as a Biomedical Resource

作为生物医学资源的黑长尾黑长尾猴研究群体

• 批准号: 7682730
• 负责人: Jay Ross Kaplan
• 金额: $ 33.6万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-14 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7682730
• 关键词: Access to Information; Age; Anatomy; Animal Experimentation; Animals; Area; Asians; Behavior; Behavior Disorders; Behavioral; Behavioral Genetics; Biomedical Research; Breeding; Cardiovascular Diseases; Caribbean natives; Caribbean region; Caring; Cercopithecidae; Cercopithecine Herpesvirus 1; Cercopithecus pygerythrus; Cercopithecus tantalus; Characteristics; Clinical; Condition; Databases; Development; Diabetes Mellitus; Disease; Funding; Genes; Genetic; Genetic Databases; Genetic Models; Genotype; Grant; Health; Individual; Infant; Macaca; Macaca mulatta; Medical History; Medicine; Metabolic syndrome; Modeling; National Center for Research Resources; Neurobiology; Numbers; Obesity; Physiological; Physiology; Positioning Attribute; Production; Purpose; Request for Applications; Research; Research Personnel; Resources; Risk; Safety; Specific Pathogen Frees; Study models; System; Training; Veterinarians; aged; animal breeding; animal care; animal resource; base; biobehavior; biomedical resource; comparative; diabetic; gene environment interaction; genetic pedigree; germ free condition; human disease; improved; interest; nonhuman primate; programs; research and development; trait; vervet

The critical shortage of rhesus monkeys has created an urgent need to develop alternative nonhuman primate models for biomedical research. The vervet / African green monkey (Chlorocebus aethiops) is an ideal candidate to fill this position. Vervets are Old World monkeys that resemble the rhesus in behavior, physiology and anatomy. Caribbean-derived vervets are readily available and are less expensive than rhesus, and because they do not carry Herpesvirus simiae (B virus), they present fewer health and safety risks than rhesus or other Asian macaque alternatives. The UCLA Vervet Research Colony (VRC) is an established center that has supported local research in vervet monkey neurobiology, behavior and genetics for 29 years, making it uniquely positioned to serve as the basis for a national resource center for vervet monkeys. The extensive genetic and behavioral database collected on vervets at the VRC make this a particularly valuable resource for collaborative research in a number of areas of biomedical interest, including obesity, diabetes, aging, psychiatric and behavioral disorders, and vulnerability for cardiovascular disease. Support from an NCRR P40 grant will enable the VRC to a) increase the supply of nonhuman primates for biomedical research by breeding US colony-born, specific pathogen free (SPF) vervets of known age and medical history for NIH-funded investigators; b) provide vervets with specific characteristics and conditions (e.g., aged, impulsive, obese, diabetic) to outside investigators; c) maintain a pedigreed, genotyped colony of vervets for use as a national resource for research on genetic contributions to faiomedicaltraits; d) provide training and information on the clinical care and management of vervets to enhance the use of this species in other centers, and e) support the continued use of vervet models for genetic, biobehavioral and neurobiological research, and the development of new vervet models for research in obesity, diabetes and metabolic syndrome. Two cores have been organized to accomplish these aims. The Animal Resources Core will manage the animal care and breedingprogram, maintain the colony record system, disseminate information on husbandry and clinicalcharacteristics of vervet monkeys, and train veterinarians in the use of vervets for biomedical research. The research component of the Animal Resources Core will focus on increasing infant viability. The Genetics and BiobehavioralCore will provide access for local and national investigators to use the multigenerational VRC pedigree and extensive database of genetic and biobehavioral information available on individual animals, and will provide statistical genetics support for outside investigators to use this resource to find genes that influence biomedical traits. The research component of the Genetics and Biobehavioral Core will contribute to the development of the vervet as a model for obesity, diabetes and metabolic syndrome. These efforts will generate critical information and provide access to animals and research opportunities that will expand the use of the vervet as an alternative nonhuman primate model for the study of human diseases and disorders.

恒河猴的严重短缺迫切需要开发替代性非人类灵长类动物 生物医学研究模型。 Vervet /非洲绿猴（Chlorocebus aethiops）是理想的候选人 填补这个位置。黄斑是旧世界的猴子，类似于行为，生理学和 解剖学。加勒比衍生的天文均可使用，并且比恒河校便宜，而且因为它们确实如此 不带疱疹病毒Simiae（B病毒），它们的健康和安全风险比恒河校或其他亚洲人更少 猕猴的替代品。 UCLA Vervet Research Colony（VRC）是一个已建立的中心，已支持当地 Vervet Monkey神经生物学，行为和遗传学的研究已有29年，使其独特地定位于 作为国家Vervet猴子资源中心的基础。广泛的遗传和行为 在VRC上收集的天线上收集的数据库使其成为一个特别有价值的资源 生物医学兴趣领域的数量，包括肥胖，糖尿病，衰老，精神病和行为障碍， 和心血管疾病的脆弱性。 NCRR P40赠款的支持将使VRC能够增加 非人类灵长类动物的供应通过繁殖美国菌落，特定病原体的生物医学研究 （SPF）NIH资助的研究人员已知的年龄和病史的斑点； b）提供特定的黄斑 外部研究人员的特征和条件（例如，老化，冲动，肥胖，糖尿病）； c）维持一个 基因分型菌落的天态菌落用作研究遗传学贡献的国家资源 FaiomedicalTraits; d）提供有关临床护理和管理的培训和信息，以增强 该物种在其他中心的使用，e）支持持续使用Vervet模型作为遗传， 生物行为和神经生物学研究，以及肥胖研究的新Vervet模型的发展， 糖尿病和代谢综合征。已经组织了两个核心来实现这些目标。动物 Resources Core将管理动物护理和育种计划，维护菌落记录系统， 传播有关Vervet猴子的饲养和临床表现的信息，并在训练兽医 生物医学研究的使用。动物资源核心的研究部分将重点放在 提高婴儿生存能力。遗传学和生物行为将为地方和国家提供访问权限 研究人员使用遗传和生物行为的多代VRC血统和广泛的数据库 有关单个动物的信息，并将为外部研究人员提供统计遗传学支持 使用此资源来找到影响生物医学特征的基因。遗传学和 生物行为核心将有助于肥胖，糖尿病和代谢的模型的生物发展 综合征。这些努力将产生关键信息，并为动物提供访问和研究 可以扩大恶习作为研究的替代性非人类灵长类动物模型的机会 人类疾病和疾病。