Biodegradable, Biocompatible Pressure Sensitive Adhesives

可生物降解、生物相容性压敏粘合剂

基本信息

批准号：
10677869
负责人：
Yolonda L Colson
金额：
$ 52.05万
依托单位：
BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-05 至 2026-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10677869
关键词：
Acrylates Adherence Adhesions Adhesives Air Air Movements Alveolar Bacteria Bacterial Infections Bandage Benign Biocompatible Materials Bronchial Injury Bypass Carbon Dioxide Carbonates Cessation of life Chemical Structure Clinical Collaborations Collagen Data Duct (organ) structure Endothelium Epithelium Ethanol Evaluation Excision Exhibits Experimental Designs Family suidae Fibroblasts Fistula Formulation Glass Glyceric Acids Glycerol Guidelines Health Care Costs Human Hydrophobicity In Vitro Infection Injury Libraries Liquid substance Lung Macrophage Medical Medical Device Safety Metals Modeling Molecular Weight Morbidity - disease rate Mus Muscle Oligonucleotides Operative Surgical Procedures Oral Paper Patient Care Performance Pleural Pleural cavity Polymers Prevention Procedures Property Pulmonary valve structure Respiration Respiratory physiology Secure Series Steel Structure Structure of parenchyma of lung Surface Surgical Staplers Surgical sutures Testing Thoracic Surgical Procedures Tissues Wood material biocompatible polymer biomaterial compatibility cancer invasiveness comparative cytotoxicity ethylene glycol experimental study functional mimics healing implantation improved in vivo in vivo Model innovative technologies lung injury mechanical behavior migration mortality novel organ injury poly(lactide)polyacrylate porcine model pressure prevent repaired response seal sealant wound

项目摘要

PROJECT SUMMARY/ABSTRACT * This proposal describes new biodegradable, biocompatible pressure sensitive adhesives (PSAs) with tunable adhesion strength for in vivo use. Thus, this innovative technology overcomes the limitation of current PSAs which are only used topically and broadens the scope of applications of such biomaterials in patient care. To highlight the utility of these new PSAs, we identified two significant and problematic clinical procedures in thoracic surgery associated with increases in health care costs and high mortality rates: the repair of alveolar- and broncho- pleural fistulae. Today, closure of such leaks is challenging due to use in a contained space and to an inherent pressure gradient across the fistula. Survival is directly related to successful fistula closure and prevention of pleural infection through the fistula. Specifically, we are evaluating novel poly(1,2-glyceric acid carbonate)s and poly(1,2-glycerol carbonate)s (PGCs) which functionally mimic conventional polyacrylate PSAs but possess biodegradable carbonate linkages and degrade into benign products – e.g., glycerol, CO2, ethanol. These first-of-their-kind polymers provide an opportunity to create a new class of PSAs and shift the paradigm around our ability to control and manage intrathoracic wounds. The proposed experiments will test the hy- potheses that these PGC based pressure sensitive adhesives will: 1) exhibit compositionally dependent adhesive strength which positively correlates with greater molecular weight, longer alkyl chains, and stereoregularity; 2) display peel strengths which can be tuned over a wide range from Post-it® note to Duct® Tape like performance; and, 3) enable securing a collagen buttress to a surgical stapler or an electrospun polylactide mesh patch for sealing lung and bronchial injuries. Importantly, preliminary data support these hypotheses, and well-characterized materials and rigorous experimental designs are established in this proposal with essential cross-disciplinary collaborations and expertise. The specific aims of this five-year proposal are: Aim 1. Synthesize and characterize a series of PGC-based pressure sensitive adhesives; Aim 2. Evaluate the compatibility of the PGC-adhesive collagen and PLA patch in vitro and in vivo, and inhibition of bacteria migration in vitro; and, Aim 3. Evaluate the performance of the PGC-adhesive collagen and PLA patch in an in vivo porcine model.

项目概要/摘要 * 该提案描述了新型可生物降解、生物相容性压敏粘合剂 (PSA) 因此，这项创新技术克服了当前的限制。 PSA 仅局部使用，扩大了此类生物材料在患者护理中的应用范围。为了强调这些新 PSA 的实用性，我们确定了两个重要但有问题的临床程序胸外科手术与医疗费用增加和高死亡率相关：肺泡修复如今，由于在密闭空间中使用，封闭此类泄漏具有挑战性。瘘管内固有的压力梯度与瘘管的成功闭合和存活直接相关。具体来说，我们正在评估新型聚（1,2-甘油酸）。碳酸酯）和聚（1,2-甘油碳酸酯）（PGC），其功能模仿传统聚丙烯酸酯压敏胶但具有可生物降解的碳酸酯键并降解成良性产物，例如甘油、二氧化碳、乙醇。这些首创的聚合物提供了创造新型 PSA 并改变范式的机会围绕我们控制和处理胸腔内伤口的能力，拟议的实验将测试hy- 假设这些基于 PGC 的压敏粘合剂将： 1) 表现出成分依赖性粘合强度与较大的分子量、较长的烷基链呈正相关，并且立体规整性；2) 显示剥离强度，可在便利贴® 便条纸到 Duct® 胶带的性能；3) 能够将胶原蛋白支撑物固定到手术缝合器或手术缝合器上用于密封肺和支气管损伤的电纺聚丙交酯网状贴片重要的是，初步数据。支持这些假设，并建立了良好表征的材料和严格的实验设计在此提案中，需要进行必要的跨学科合作和专业知识，以明确本五年的具体目标。建议是：目标 1. 合成并表征一系列基于 PGC 的压敏粘合剂；目标 2。评估 PGC 粘合胶原蛋白和 PLA 贴片在体外和体内的相容性，以及对细菌体外迁移；目标 3. 评估 PGC 粘合胶原蛋白和 PLA 贴片的性能在猪体内模型中。