BETA-CELL FAILURE IN OBESE AFRICAN-AMERICANS WITH HYPERGLYCEMIC CRISIS

患有高血糖危机的肥胖非洲裔美国人的 β 细胞衰竭

• 批准号: 7603615
• 负责人: Guillermo E Umpierrez
• 金额: $ 0.35万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7603615
• 关键词: African American; B-Lymphocytes; Beta Cell; Computer Retrieval of Information on Scientific Projects Database; Diabetic Ketoacidosis; Elevation; Failure; Functional disorder; Funding; Glucose; Grant; Hyperglycemia; Institution; Nonesterified Fatty Acids; Obesity; Plasma; Research; Research Personnel; Resources; Source; Testing; Toxic effect; United States National Institutes of Health; African American; B-Lymphocytes; Beta Cell; Computer Retrieval of Information on Scientific Projects Database; Diabetic Ketoacidosis; Elevation; Failure; Functional disorder; Funding; Glucose; Grant; Hyperglycemia; Institution; Nonesterified Fatty Acids; Obesity; Plasma; Research; Research Personnel; Resources; Source; Testing; Toxic effect; United States National Institutes of Health

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will test the hypothesis that obese African Americans with diabetic ketoacidosis are susceptible to B-cell dysfunction due to sustained elevations of plasma glucose (glucose toxicity) and/or free fatty acid levels (lipotoxicity).

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究将检验以下假设：由于血浆葡萄糖的持续升高（葡萄糖毒性）和/或游离脂肪酸水平（Lipotototoxicity），患有糖尿病性酮症酸中毒的肥胖非洲裔美国人容易受到B细胞功能障碍的影响。