Cell Biology of TLR Signal Transduction

TLR 信号转导的细胞生物学

• 批准号: 8257885
• 负责人: Ruslan Medzhitov
• 金额: $ 40.66万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8257885
• 关键词: Adenosine; Anti-Inflammatory Agents; Anti-inflammatory; Biological; Cells; Cellular biology; Complex; Data; Family member; Grant; Homeostasis; Host Defense; Infection; Inflammation; Inflammatory Response; Injury; Instruction; Interleukin-10; Mediating; Molecular; Output; Pathway interactions; Play; Regulation; Role; Signal Pathway; Signal Transduction; Specificity; TLR2 gene; TLR4 gene; Tissues; Toll-like receptors; base; human disease; insight; prevent; repaired; response

Toll-like receptors play a critical role in host defense from infection, as well as in a variety of inflannmatory responses, tissue homeostasis and repair. TLRs induce a highly-complex cellular and transcriptional responses. Specific activation of different responses by TLR family members is mediated by utilization of distinct signaling pathways by different TLRs. This project is focused on the characterization ofthe mechanisms of differential signaling by TLRs that control distinct cellular outputs. We also investigate the mechanisms of negative regulation of TLR induced responses. We are also investigating the mechanisms of TLR induced inflammasome activation and its negative regulation by a variety of anti-inflammatory signals, including IL-10 and adenosine. RELEVANCE (See instructions): Inflammatory responses are critical for the protection from infection and tissue injury. However, inflammation is also a major underlying component of a variety of human diseases. Better understanding of the regulation of inflammation is needed in order to regulate the response in a way that prevents detrimental aspects of inflammation. The aim of the project is to characterize these regulatory principles and mechanisms.

Toll样受体在免受感染的宿主防御以及多种燃烧性中起着至关重要的作用 反应，组织稳态和修复。 TLR诱导高复杂的细胞和转录 回答。 TLR家族成员对不同反应的特定激活是通过利用来介导的 不同TLR的不同信号通路。该项目的重点是 TLR控制不同细胞输出的TLR差异信号的机制。我们还调查了 TLR诱导反应的负调控机制。我们还正在研究 TLR诱导炎症体激活及其通过多种抗炎信号的负调控， 包括IL-10和腺苷。 相关性（请参阅说明）： 炎症反应对于保护感染和组织损伤至关重要。但是，炎症 也是各种人类疾病的主要基础。更好地理解法规 为了以防止有害方面的方式调节反应，需要发炎 炎。该项目的目的是表征这些监管原理和机制。