Behavioral Core B

行为核心B

• 批准号: 10676992
• 负责人: Rachel Elizabeth Miller
• 金额: $ 15.92万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-14 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10676992
• 关键词: Address; Analgesics; Animal Model; Animals; Anxiety; Arthritis; Behavior; Behavior assessment; Behavioral; Behavioral Assay; Biological Assay; Chicago; Collaborations; Communities; Consultations; Degenerative polyarthritis; Development; Disease; Disease model; Educational Activities; Educational Materials; Equipment; Evaluation; Experimental Models; Female; Fostering; Geography; Goals; International; Laboratories; Leadership; Modeling; Musculoskeletal; Musculoskeletal Diseases; Musculoskeletal Pain; Needs Assessment; Neurobiology; Outcome; Pain; Pathway interactions; Patients; Persons; Phenotype; Pre-Clinical Model; Proprioception; Protocols documentation; Qualifying; Research; Research Personnel; Research Support; Research Training; Resources; Rheumatism; Rheumatoid Arthritis; Rodent; Rodent Model; Services; Social Behavior; Surveys; Technical Expertise; Testing; Time; Training; Training Activity; behavior measurement; behavior test; design; experience; innovation; male; new technology; novel; novel therapeutics; pain behavior; pre-clinical; preclinical study; prevent; somatosensory; spontaneous pain; synergism; testing services; tool; virtual; web portal

Project summary The overarching goal of the Chicago Center on Musculoskeletal Pain (C-COMP) is to foster and support research and training aimed at understanding the mechanisms underlying pain in musculoskeletal (MSK) disease, with the ultimate goal of better managing and preventing it. Assessment of disease-specific pain- related behaviors and other somatosensory changes in appropriate preclinical models of rheumatic and MSK diseases is one of the cornerstones for the study of mechanisms underlying pain associated with these diseases, necessary for the development of new therapeutics for MSK pain. The Behavioral Core B will support this goal by providing unique resources, world class expertise, and effective training to assess behavioral changes in animal models of MSK and rheumatic diseases. We will capitalize on our combined expertise in models of osteoarthritis and other MSK diseases, and we will engage world class experts in rodent pain behaviors to provide continued guidance. This approach will support much needed high-quality research and training in this field and will facilitate a more wide-spread use of appropriate behavioral measures as outcomes in preclinical studies of MSK disease. Such a service is a prerequisite for exploring mechanisms underlying pain associated with MSK diseases, and for increasing the translational utility of animal models. Ultimately, we expect that choosing the right behaviors in the right models will aid the development of novel, safe, and efficacious analgesics. The behavioral assays offered in Core B have been chosen to synergize with Neurobiology Core C, which will further enable mechanistic evaluation of pain pathways. Our own combined cumulative experience and established innovation and international leadership in the behavioral characterization of rodent models of MSK diseases provides us with unique qualifications to advise and support researchers about the most efficient strategies to evaluate behavioral changes in MSK models. The Core will achieve its objectives through the following aims: Aim 1. Establish a centralized resource to facilitate behavioral assays in MSK disease models. We will provide a full panel of behavioral assays that cover all types of somatosensory changes. The Core will provide hands-on training in animal behavioral testing, customized protocols, equipment, and testing space. Aim 2. Provide a consultation service, and a customized, full-service option for applying behavioral testing to preclinical models of arthritis and MSK disease. The Core will provide scientific guidance for the design of studies and consulting services on how to apply behavioral testing to MSK models. The Core will provide technical expertise to make customized, full- service behavioral testing options available to laboratories, including labs outside of Chicago. Aim 3. Train the research community in evaluating behavioral changes in models of arthritis and other MSK diseases. We will provide both in person and virtual training, present seminars and develop educational material to enhance Center investigators’ understanding of how to integrate behavioral testing into their laboratories.

项目概要 芝加哥肌肉骨骼疼痛中心 (C-COMP) 的总体目标是促进和支持 旨在了解肌肉骨骼 (MSK) 疼痛机制的研究和培训 疾病，最终目标是更好地管理和预防疾病特异性疼痛。 适当的风湿病和 MSK 临床前模型中的相关行为和其他体感变化 疾病是研究与这些疾病相关的疼痛机制的基石之一 疾病，是开发 MSK 疼痛新疗法所必需的行为核心 B。 通过提供独特的资源、世界一流的专业知识和有效的评估培训来支持这一目标 我们将利用 MSK 斯隆和风湿病动物模型的行为变化。 骨关节炎和其他 MSK 斯隆疾病模型方面的专业知识，我们将聘请世界一流的啮齿动物专家 这种方法将支持急需的高质量研究。 和该领域的培训，并将促进更广泛地使用适当的行为措施， MSK 疾病临床前研究的结果是探索机制的先决条件。 与 MSK 疾病相关的潜在疼痛，以及提高动物模型的转化效用。 最终，我们期望在正确的模型中选择正确的行为将有助于开发新颖的、 已选择核心 B 中提供的安全、有效的镇痛药进行分析以与其产生协同作用。 神经生物学核心 C，这将进一步实现我们自己的组合疼痛通路的机械评估。 积累经验并在行为领域确立创新和国际领导地位 MSK 疾病啮齿动物模型的表征为我们提供了独特的资格来提供建议和 支持研究人员采用最有效的策略来评估 MSK 模型中的行为变化。 Core 将通过以下目标实现其目标： 目标 1. 建立集中资源 促进 MSK 疾病模型中的行为测定。我们将提供一整套行为测定。 涵盖所有类型的体感变化，核心将提供动物行为的实践培训。 目标 2. 提供咨询服务和测试空间。 将行为测试应用于关节炎和 MSK 临床前模型的定制全方位服务选项 该核心将为有关如何治疗疾病的研究和咨询服务的设计提供科学指导。 The Core 将提供技术专业知识，以制作定制的、全面的模型。 向实验室（包括芝加哥以外的实验室）提供行为测试服务选项 目标 3. 培训实验室。 研究界评估关节炎和其他 MSK 疾病模型的行为变化。 我们将提供面对面和虚拟培训、举办研讨会并开发教育材料 增强中心研究人员对如何将行为测试整合到实验室的理解。