Preventing exposure to ticks and tick-borne illness in outdoor workers

预防户外工作人员接触蜱虫和蜱传疾病

• 批准号: 8300696
• 负责人: Steven Richard Meshnick
• 金额: $ 29.3万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8300696
• 关键词: Preventing; exposure; ticks; tick; borne

Preventing exposure to ticks and tick-borne illness in outdoor workers ABSTRACT In North Carolina, tick-borne diseases represent a growing public health problem and an occupational hazard for outdoor workers. Currently, tick-bite prevention requires time- consuming reapplication of insecticides to clothing and exposed skin. Unfortunately, adherence to these procedures is poor. Recently, a factory-based method for long- lasting permethrin impregnation of clothing has been developed which allows clothing to retain insecticidal activity for over 70 washes (the effective lifetime of a garment). The treatment process has been approved by the US EPA and classified as non-toxic. We have preliminary evidence from a small pilot project suggesting that workers wearing this clothing have ~90% fewer tick bites than workers not wearing this clothing. In order to measure the effectiveness and safety of this clothing in protecting outdoor workers, we are proposing a randomized controlled intervention with 300 workers in the NC State Department of Environmental and Natural Resources (DENR). Outdoor workers in the Division of Forestry and the Division of Parks and Recreation will be randomly assigned to two groups. Workers will have their uniforms treated or sham-treated in a double- blinded manner. All study subjects will fill out weekly tick logs, and keep removed ticks in specimen vials for later speciation and pathogen detection. Serum samples, drawn at enrollment and study conclusion will be titered for antibody to common tick-borne pathogens. Possible clothing-related adverse events, such as rashes, will be recorded. The results of this study could lead to a simple and cost-effective method of protecting outdoor workers from tick-borne illnesses.

防止在户外工作人员中暴露于tick虫和tick虫疾病 抽象的 在北卡罗来纳州，tick传播疾病代表了日益增长的公共卫生问题和 户外工人的职业危害。目前，预防tick咬需要时间 - 将杀虫剂重新涂在衣服和裸露的皮肤上。很遗憾， 遵守这些程序很差。最近，一种基于工厂的方法 已经开发了持久的苄氯菊酯浸渍衣服，使衣服允许服装 保留70多次洗涤的杀虫活性（服装的有效寿命）。这 治疗过程已得到美国EPA的批准，并被归类为无毒。我们 有一个小型飞行员项目的初步证据，表明佩戴此的工人 服装比不穿这种衣服的工人少了滴答的滴答性约90％。为了 衡量这件衣服在保护户外工人方面的有效性和安全性，我们 正在提议与NC状态的300名工人进行随机控制干预措施 环境与自然资源部（DENR）。户外工人 将随机分配林业和公园和娱乐部 到两组。工人将以双重治疗或假处理的制服 盲人的方式。所有学习科目都将填写每周的滴答记录，并保持删除的壁虱 在标本小瓶中，用于以后的物种形成和病原体检测。血清样品，在 入学和研究结论将用于抗与常见tick传播的抗体 病原体。可能会记录可能与服装相关的不良事件，例如皮疹。 这项研究的结果可能导致一种简单且具有成本效益的保护方法 tick传播疾病的户外工人。