Workshop on Techniques in Modeling Human Cancer in Mice

人类癌症小鼠模型技术研讨会

• 批准号: 10674819
• 负责人: DAVID W. THREADGILL
• 金额: $ 8.46万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10674819
• 关键词: Autopsy; Award; Basic Cancer Research; Biomedical Research; Blood; Bone Marrow; Brain; Breast; Cancer Model; Characteristics; Collaborations; Collection; Colon; Colon Carcinoma; Communities; Complement; Development; Diné Nation; Dissection; Education; Educational workshop; Endoscopy; Environment; Exhibits; Faculty; Faculty Workshop; Fatty acid glycerol esters; Feedback; Gastrointestinal tract structure; Genetic; Genetic Engineering; Genomics; Goals; Grant; Histology; Home; Image; Imaging Techniques; Immersion; Immunology; Infrastructure; Injections; Institution; Instruction; Intubation; Knowledge; Laboratories; Laboratory mice; Learning; Lung; Maine; Malignant Neoplasms; Malignant neoplasm of prostate; Medical; Minority Groups; Modernization; Mouse Mammary Tumor Virus; Mus; NCI Center for Cancer Research; Operative Surgical Procedures; Orchiectomy; Organ; Organoids; Participant; Pathologist; Pathology; Perfusion; Phenotype; Positioning Attribute; Postdoctoral Fellow; Preparation; Prostate; Recording of previous events; Recruitment Activity; Research; Research Personnel; Research Project Grants; Resources; Schedule; Scholarship; Scientist; Site; Slide; Spleen; Splenocyte; Students; Techniques; The Jackson Laboratory; Tissues; Training; Underrepresented Minority; Work; Xenograft procedure; anticancer research; biomedical scientist; body system; career; experience; faculty-student interactions; graduate student; human cancer mouse model; human model; implantation; knowledge base; laboratory experience; lectures; lymph nodes; malignant breast neoplasm; mammary; meetings; member; mouse model; mutant mouse model; peer; programs; recruit; skills; symposium; tissue fixing; tool; tumor; ventilation

PROJECT SUMMARY/ABSTRACT The overall goal for the annual “Workshop on Techniques in Modeling Human Cancer in Mice” proposed in this application is to deliver an intensive cutting-edge training workshop on modeling human cancer in the laboratory mouse to a small group of select early career scientists/trainees. Participants completing the course will acquire a working knowledge of how to characterize and analyze mouse models of human cancer. The course will consist of didactic lectures in the morning to introduce particular organ sites and the characteristics of cancers associated with those organ sites, followed by intensive hands-on laboratory sessions whereby students will gain experience in the manipulation and analysis of mouse models of human cancer. As a global resource for genetically engineered and mutant mouse models, JAX is uniquely positioned to provide a hands-on training experience that is not available anywhere else in the world. Sessions will also include imaging techniques, surgical approaches to the implantation of tumors and pathology. Additionally, participants have the opportunity to present their work and receive constructive feedback from course faculty and participants. JAX is deeply committed to training a diverse group of biomedical scientists. With support from NCI and the Howard Hughes Medical Institute, we will actively recruit and train under-represented minority (URM) participants through extensive partnerships, thoughtful planning and use of scholarship resources. Additionally, we will actively seek and invite URMs to serve as workshop faculty. This intensive 7-day immersive course will be offered to 20 participants selected for their outstanding research potential. They will interact with a group of prominent mouse geneticists and cancer biologists both from JAX and other prominent institutions. The size of the class will be kept deliberately small in order to achieve a desirable level of student-faculty interaction and to permit extensive laboratory training and practice. The course will be held annually at Highseas, our residential conference facility and our generously equipped applied genomic training laboratory. The Jackson Laboratory is an NCI-designated Basic Research Cancer Center and has a long history of hosting advanced courses and scientific meetings.

项目概要/摘要 本年度提出的“人类癌症小鼠模型技术研讨会”的总体目标 该应用程序是在实验室中举办关于人类癌症建模的密集前沿培训研讨会 完成课程的参与者将获得一小群选定的早期职业科学家/学员的鼠标。 关于如何表征和分析人类癌症小鼠模型的实用知识。 该课程将包括上午的教学讲座，介绍特定的器官部位和 与这些器官部位相关的癌症的特征，然后进行密集的实验室实践课程 由此，学生将获得操作和分析人类癌症小鼠模型的经验。 JAX 是基因工程和突变小鼠模型的全球资源，具有独特的优势，可以提供 世界其他地方无法提供的实践培训经验还将包括成像。 技术、肿瘤植入的手术方法和病理学。 有机会展示他们的作品并获得课程教师和参与者的建设性反馈。 JAX 致力于在 NCI 和 NCI 的支持下培养多元化的生物医学科学家。 霍华德休斯医学院，我们将积极招募和培训代表性不足的少数族裔 (URM) 参与者 此外，我们将通过广泛的合作伙伴关系、深思熟虑的规划和奖学金资源的使用。 积极寻找并邀请URM担任研讨会教员。 这个为期 7 天的沉浸式强化课程将提供给 20 名因杰出研究而被选中的参与者 他们将与 JAX 的一群著名小鼠遗传学家和癌症生物学家进行互动。 和其他著名机构的班级规模将故意保持较小，以实现 学生与教师互动的理想水平，并允许广泛的实验室培训和实践。 每年将在我们的住宿会议设施 Highseas 和设备齐全的应用中心举办 杰克逊实验室是 NCI 指定的基础研究癌症中心和 拥有举办高级课程和科学会议的悠久历史。

项目成果

Cnidarian microRNAs frequently regulate targets by cleavage.

刺胞动物 microRNA 经常通过切割来调节靶标。

• 发表时间: 2014-04
• 影响因子: 7
• 作者: Moran, Yehu;Fredman, David;Praher, Daniela;Li, Xin Z;Wee, Liang Meng;Rentzsch, Fabian;Zamore, Phillip D;Technau, Ulrich;Seitz, Hervé
• 通讯作者: Seitz, Hervé