Core 2: Biostatistics and BioInformatics Core

核心2：生物统计学和生物信息学核心

基本信息

批准号：
10673999
负责人：
Menggang Yu
金额：
$ 29.05万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-08-02 至 2027-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10673999
关键词：
Achievement Adult Applications Grants Architecture Area Award Bioinformatics Biometry Biostatistics Shared Resource Cancer Center Cancer cell line Clinical Clinical Research Collaborations Communities Complex Computer software Consultations Data Data Analyses Data Collection Data Set Database Management Systems Databases Dedications Development Ensure Environment Experimental Designs Extramural Activities Faculty Formulation Grant Head and Neck Cancer Human Resources Image Informatics Information Dissemination Infrastructure Joints Laboratories Laboratory Study Leadership Malignant Neoplasms Manuscripts Maps Medical Informatics Methodology Methods Movement Operative Surgical Procedures Participant Pathology Pharmacotherapy Procedures Publications Pythons Radiation Recommendation Recording of previous events Research Research Design Research Methodology Research Personnel Role Secure Specialist Statistical Data Interpretation System Tissue Microarray Translations Triage Universities Validation Wisconsin Writing archive data career clinical database cost effective cost efficient data archive data integrity data management data quality/integrity data sharing data standards data warehouse electronic data empowerment experience experimental study head and neck cancer patient human error informatics shared resource programs research study success translational cancer research

项目摘要

PROJECT SUMMARY The objective of the Biostatistics and Bioinformatics Core (Biostats Core) of the Wisconsin Head and Neck Cancer (HNC) SPORE is to promote excellence in HNC translational research by providing dedicated and outstanding biostatistical and bioinformatic consultation and collaborative support to the HN SPORE projects, Pathology Core, Administrative Core, and other investigators whose projects are supported under the Developmental Research and Career Enhancement Programs. This support and collaboration will include laboratory, translational, and clinical-based research, focusing on translation from laboratory studies to clinical studies. The Biostats Core will achieve its objective by supporting investigators and providing statistical, informatic, and data management expertise, thus enhancing the quality and ensuring the validity of the research undertaken in the HN SPORE. The Biostats Core will provide expertise in all stages of the research: from formulation of research questions through study experimental design, data collection and management, to data analysis, interpretation and dissemination of results through publications. The Specific Aims of the Core are: Aim 1. To maintain devoted collaboration with the HN SPORE investigators in the design of research studies, in analysis and interpretation of data, and in writing of scientific manuscripts disseminating the HN SPORE results to the scientific community. Aim 2. To upgrade the current HN SPORE data architecture to a single and unified environment that enhances the current database management activities to ensure the transparency and validity of statistical and bioinformatic analysis via centralized data management and standardization, confidential and secure data archiving and sharing, and data validation and consistency check. Aim 3. To conduct, when necessary, methodology research to develop new statistical and bioinformatic methods and software relevant to the HN SPORE projects.

项目概要威斯康星州头颈医院生物统计学和生物信息学核心（Biostats Core）的目标 Cancer (HNC) SPORE 旨在通过提供专门和为 HN SPORE 项目提供出色的生物统计和生物信息咨询和协作支持，病理学核心、行政核心以及其项目得到资助的其他研究人员发展研究和职业提升计划。这种支持和合作将包括实验室、转化和临床研究，重点关注从实验室研究到临床的转化研究。 Biostats 核心将通过支持研究人员并提供统计、信息和数据管理专业知识，从而提高质量并确保研究的有效性在 HN SPORE 进行。 Biostats Core 将提供研究各个阶段的专业知识：通过研究实验设计、数据收集和管理来制定研究问题通过出版物分析、解释和传播结果。核心的具体目标是：目标 1. 在研究设计方面与 HN SPORE 研究人员保持密切合作，数据分析和解释，以及撰写传播 HN SPORE 的科学手稿将结果提交给科学界。目标 2. 将当前的 HN SPORE 数据架构升级为单一且统一的环境，加强现有数据库管理活动，确保统计数据的透明度和有效性通过集中数据管理和标准化进行生物信息分析，保密且安全数据归档和共享，以及数据验证和一致性检查。目标 3. 必要时进行方法论研究以开发新的统计和生物信息学与 HN SPORE 项目相关的方法和软件。