Carolina Center of Cancer Nanotechnology Excellence

卡罗莱纳州癌症纳米技术卓越中心

• 批准号: 8136711
• 负责人: JOSEPH M. DESIMONE
• 金额: $ 250.87万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8136711
• 关键词: Carolina; Center; Cancer; Nanotechnology; Excellence

The Carolina CCNE is focused on improving cancer disease control and management by utilizing exciting new and cutting edge nanotechnologies, developed from our first CCNE efforts,. Our efforts will work to improve the quality and duration of life and disease outcome for cancer patients by enhancing treatment and early detection. We propose five projects in two major areas as follows: Nano-Particle Based Biological and Chemotherapy includes Project 1: PRINT Nanoparticles: "Calibration Quality" Nano-tools for Studying Particle Biodistribution, Project 2: Ras pathway siRNA in Lung Cancer, and Project 3: Translational Nanosystems Chemotherapy in Lung Cancer. Carbon Nanotube Based Radiation Therapy and Early Detection include Project 4: Compact Micro Beam Radiation Therapy in Brain Cancer and Project 5: Digital Breast Tomosynthesis System. The proposed nanoparticle science is primarily focused on targeted delivery of biological (siRNA) and chemotherapy to cancer cells. A key basic science question we will address is the implications of nanoparticle size, shape and modulus in accessing various tissues in the body. This question can effectively be answered by the UNC-developed PRINT technology, which features exquisite control over particle properties and will result in the establishment of BioMaps for nanoparticle delivery. Two additional nanoparticle-based projects will deliver biological and chemotherapy in a targeted fashion to lung cancer, with four distinct nanoparticle types that are capable of carrying multiple payloads. We will establish the first direct comparison of efficacy and toxicity of these various approaches against the equivalent of clinical standard of care in sophisticated murine cancer models. With carbon nanotube-based field emission X-ray technology, a new compact microbeam radiation therapy source is proposed that will deliver high intensity and spatially distributed radiotherapy to high grade gliomas and other brain cancers. Lastly, a carbon nanotube-based clinic-ready breast tomosynthesis imaging device is proposed that would advance early detection and characterization of breast abnormalities, and help to distinguish cancer from benign disease. We believe that developing these technologies and preparing them for clinical trials will help in realizing the promise of nanotechnology in cancer care and positively impact the lives of cancer patients.

卡罗来纳州CCNE致力于通过利用令人兴奋的新和最前沿的纳米技术来改善癌症疾病的控制和管理，这是根据我们的第一次CCNE努力开发的。我们的努力将通过增强治疗和早期检测来提高癌症患者的生命和疾病结局的质量和持续时间。我们在两个主要领域提出了五个项目：基于纳米粒子的生物学和化学疗法包括项目1：印刷纳米颗粒：用于研究颗粒生物分布的“校准质量”，项目2：肺癌中的Ras Pathway sirna和Project 3：转化纳米系统化学疗法。基于碳纳米管的放射疗法和早期检测包括项目4：脑癌和项目5的紧凑型微束辐射疗法：数字乳房间隙系统。拟议的纳米粒子科学主要集中于靶向递送生物学（siRNA）和化学疗法对癌细胞的递送。我们将要解决的一个关键基础科学问题是纳米颗粒大小，形状和模量在获取体内各种组织中的含义。 UNC开发的印刷技术可以有效地回答这个问题，该技术具有对粒子特性的精美控制，并将导致建立用于纳米颗粒传递的生物膜。另外两个基于纳米颗粒的项目将以有针对性的方式为肺癌提供生物学和化学疗法，其中四种不同的纳米颗粒类型能够携带多个有效载荷。我们将在复杂的鼠类癌模型中，将这些方法的功效和毒性与相当于临床护理标准的等效物进行首次直接比较。借助基于碳纳米管的现场发射X射线技术，提出了一种新的紧凑型微型放射治疗源，该疗法将向高级别的神经胶质瘤和其他脑癌提供高强度和空间分布的放射治疗。最后，提出了一种基于碳纳米管的诊所就绪的乳房合成成像装置，该设备将提高乳房异常的早期检测和表征，并有助于区分癌症与良性疾病。我们认为，开发这些技术并为临床试验做准备将有助于实现纳米技术在癌症护理中的希望，并积极影响癌症患者的生活。