Translational Research Training inCancer Etiology & Prevention

癌症病因学转化研究培训

• 批准号: 10673621
• 负责人: Jian-Min Yuan
• 金额: $ 12.37万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-05 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10673621
• 关键词: Etiology; Prevention; Research Training; Translational Research

Given the severe shortfall of research scientists who are capable of conducting comprehensive studies that can translate fundamental knowledge from the bench to the clinical and the community settings for the improvement of cancer prevention and control, the purpose of this research training program is to provide integrated training in an inter-disciplinary research and teaching setting at the University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center. Trainees will be trained in understanding the role of environmental exposures and genetic and other physiological factors in the development and progression of cancer in humans. The training program involves cross-disciplinary training courses in different tracks in the Clinical Trial Research, the Translational Research, and the Population-Based Observational and Interventional Research on cancer. Trainees will work with experienced mentors in a multiple disciplinary team conducting researches from mechanistic experiments and observational studies in populations to randomized intervention studies to test the efficacy of chemo- and immuno-preventive agents on cancer protection in humans. The mentored research will provide direct research experience to trainees in study design, methodological development, implementation of research protocol, data collection, analysis and interpretation, and manuscript preparation and publication. Trainees also will learn how to translate discoveries from pre-clinical experimental and/or observational studies into randomized interventional studies for cancer prevention. The unique training of this program will train next generation of scientists who can lead the cutting-edge translational research on cancer etiology and prevention. This training program is a joint effort of 23 preceptors who are conducting active research projects all with independent research funding in University of Pittsburgh. These faculties are from the following research programs: Cancer Epidemiology and Prevention Program; Breast and Ovarian Cancer Program; Biobehavioral Oncology Program; Cancer Immunology Program; Cancer Therapeutics Program; Head & Neck Cancer Program; Lung Cancer Program; and Molecular and Cellular Cancer Biology Program at the UPMC Hillman Cancer, a top-ranked Comprehensive Cancer Center with $94 million direct research funding in 2017. Trainees will receive cutting-edge translational research training and experience. We request continuing funding to support 3 postdoctorates and one predoctorate per year for 5 years. Our recent data on applicant recruitment, retention and training experience demonstrate a relatively large pool of candidates with high academic performance. In addition, we successfully enrolled one-third trainees from the underrepresented racial and ethnical groups. The progress and success of the training program will continue to track the career development and research activities of past trainees in the 10 years post-training.

鉴于能够进行综合研究的研究科学家严重短缺 可以将基础知识从实验室转化为临床和社区环境 改善癌症预防和控制，该研究培训计划的目的是提供 匹兹堡大学医学院跨学科研究和教学环境的综合培训 中心 (UPMC) 希尔曼癌症中心。学员将接受培训，了解环境的作用 暴露以及遗传和其他生理因素在癌症发生和进展中的作用 人类。培训计划涉及临床不同轨道的跨学科培训课程 试验研究、转化研究以及基于人群的观察和干预 癌症研究。学员将与多学科团队中经验丰富的导师一起进行 从机械实验和人群观察研究到随机干预的研究 研究测试化学和免疫预防剂对人类癌症保护的功效。这 指导性研究将为学员提供研究设计、方法学方面的直接研究经验 研究方案的制定、实施、数据收集、分析和解释以及手稿 准备和出版。学员还将学习如何转化临床前实验的发现 和/或癌症预防随机干预研究的观察性研究。独特的培训 该计划的目的是培养能够领导前沿转化研究的下一代科学家 癌症的病因学和预防。 该培训计划是 23 名导师的共同努力，他们正在积极开展研究项目 拥有匹兹堡大学的独立研究经费。这些能力来自以下研究 项目：癌症流行病学和预防项目；乳腺癌和卵巢癌计划；生物行为 肿瘤学项目；癌症免疫学项目；癌症治疗计划；头颈癌 程序;肺癌计划； UPMC Hillman 的分子和细胞癌症生物学项目 Cancer，一流的综合癌症中心，2017 年直接研究经费为 9,400 万美元。学员 将接受尖端的转化研究培训和经验。 我们请求持续资助，每年支持 3 名博士后和 1 名博士预科人员，为期 5 年。 我们最近关于申请人招聘、保留和培训经验的数据表明，人才库相对较大 具有高学术表现的候选人。此外，我们还成功招收了三分之一的学员 代表性不足的种族和族裔群体。培训计划的进展和成功将 继续跟踪过去学员在培训后10年内的职业发展和研究活动。

项目成果

Incidence of hepatocellular carcinoma in nonalcoholic fatty liver disease without cirrhosis or advanced liver fibrosis.

无肝硬化或晚期肝纤维化的非酒精性脂肪性肝病中肝细胞癌的发病率。

• 发表时间: 2023-07-01
• 影响因子: 5.1
• 作者: Behari, Jaideep;Gougol, Amir;Wang, Renwei;Luu, Hung N;Paragomi, Pedram;Yu, Yi;Molinari, Michele;Chopra, Kapil;Malik, Shahid M;Geller, David;Yuan, Jian
• 通讯作者: Yuan, Jian

Participation in Physical Activity and Risk for Amyotrophic Lateral Sclerosis Mortality Among Postmenopausal Women.

绝经后妇女参加体力活动和肌萎缩侧索硬化症死亡率的风险。

• 发表时间: 2016-03
• 影响因子: 29
• 作者: Eaglehouse, Yvonne L;Talbott, Evelyn O;Chang, Yuefang;Kuller, Lewis H
• 通讯作者: Kuller, Lewis H

Urinary Cotinine Is as Good a Biomarker as Serum Cotinine for Cigarette Smoking Exposure and Lung Cancer Risk Prediction.

尿可替宁与血清可替宁一样，是吸烟暴露和肺癌风险预测的良好生物标志物。

• 发表时间: 2020-01
• 作者: Thomas, Claire E;Wang, Renwei;Adams;Murphy, Sharon E;Ueland, Per Magne;Midttun, Øivind;Brennan, Paul;Johansson, Mattias;Gao, Yu;Yuan, Jian
• 通讯作者: Yuan, Jian

Post-Acute Pancreatitis Pancreatic Exocrine Insufficiency: Rationale and Methodology of a Prospective, Observational, Multicenter Cohort Study.

急性胰腺炎后胰腺外分泌功能不全：前瞻性、观察性、多中心队列研究的基本原理和方法。

• 发表时间: 2021-02-01
• 影响因子: 2.9
• 作者: Paragomi, Pedram;Phillips, Anna Evans;Machicado, Jorge D;Lahooti, Ali;Kamal, Ayesha;Afghani, Elham;Pothoulakis, Ioannis;Reynolds, Shari L;Mays, Melanie;Conwell, Darwin L;Lara, Luis F;Singh, Vikesh K;Papachristou, Georgios I
• 通讯作者: Papachristou, Georgios I

The Association between Serum Serine and Glycine and Related-Metabolites with Pancreatic Cancer in a Prospective Cohort Study.

前瞻性队列研究中血清丝氨酸和甘氨酸及相关代谢物与胰腺癌之间的关联。

• 发表时间: 2022-04-28
• 影响因子: 5.2
• 作者: Luu, Hung N;Paragomi, Pedram;Wang, Renwei;Huang, Joyce Y;Adams;Midttun, Øivind;Ulvik, Arve;Nguyen, Tin C;Brand, Randall E;Gao, Yutang;Ueland, Per Magne;Yuan, Jian
• 通讯作者: Yuan, Jian