Effects of Prenatal Alcohol Exposure at 22 Years

22 岁时产前接触酒精的影响

基本信息

批准号：
7894963
负责人：
NANCY Lee DAY
金额：
$ 17.81万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-07-20 至 2011-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7894963
关键词：
Adolescence Adolescent Adult Affect African American Age Alcohol consumption Alcohol or Other Drugs use Alcohols Arousal Attention Beer Behavior Behavioral Behavioral inhibition Belief Caucasians Caucasoid Race Characteristics Child Childhood Clinic Cognitive Cognitive deficits Data Data Analyses Data Set Development Diagnosis Diagnostic Dose Drug usage Employment Environment Family Fetal Alcohol Exposure Fetal Alcohol Syndrome Frequencies Funding Growth Household Infant Interview Lead Learning Light Long-Term Effects Marijuana Measures Mediator of activation protein Memory Modeling Morphology Mothers National Institute on Alcohol Abuse and Alcoholism Neuraxis Occupational Occupations Outcome Parenting behavior Pattern Performance Phase Population Pregnancy Pregnancy Trimesters Pregnant Women Problem behavior Protocols documentation Psychiatric Diagnosis Regulation Role Shapes Sleep Social Problems Symptoms Theoretical model Time Tobacco Wine Woman age effect alcohol exposure binge drinking cell motility cohort distilled alcoholic beverage drinking early onset executive function eye hand coordination feeding fetal marijuana exposure infancy male men neuropsychological offspring prenatal primary outcome psychologic public health relevance response secondary outcome social young adult

项目摘要

DESCRIPTION (provided by applicant): From childhood through adolescence, we have found that prenatal alcohol exposure (PAE) predicts deficits in growth, morphology, and CNS development, the three domains that define Fetal Alcohol Syndrome. We have found these effects across the spectrum of alcohol use, demonstrating that PAE has significant effects at light, moderate, and high levels of exposure. This is particularly important to document in light of the still widespread belief that low-level alcohol consumption by pregnant women is safe. The majority of the women in our cohort drank at light and moderate levels, although we had drinkers across the spectrum of alcohol use. The number of low and moderate drinkers in our cohort has uniquely allowed us to identify the effects of low and moderate levels of alcohol exposure during gestation in addition to the effects of high levels of alcohol use, abuse, and binge drinking. Having data across the spectrum of use also gives us the ability to define the shape of the relations between PAE and the outcomes and to explore whether these associations are best modeled as dose-response or threshold relations. This proposal is to analyze data on the offspring and their mothers when the offspring are age 22. We will identify the effects of PAE at age 22, and we will integrate the 22-year assessment with the prior 10 phases to look at the trajectories of development from gestation through infancy, childhood, adolescence, and young adulthood. PUBLIC HEALTH RELEVANCE: Prenatal alcohol exposure has significant effects on the development of the central nervous system, growth, and morphology. At high levels of exposure, effects across these three domains lead to Fetal Alcohol Syndrome. Little is known about the effects of lower levels of alcohol exposure during gestation. This is a proposal to identify the effects of low and moderate, as well as heavy levels of prenatal alcohol exposure.

描述（由申请人提供）：从童年到青春期，我们发现产前酒精暴露（PAE）可预测生长、形态和中枢神经系统发育缺陷，这三个领域定义了胎儿酒精综合症。我们在整个饮酒范围内发现了这些影响，证明 PAE 在轻度、中度和高水平暴露下都有显着影响。鉴于人们仍然普遍认为孕妇少量饮酒是安全的，这一点尤为重要。尽管我们的饮酒者的饮酒范围各不相同，但我们队列中的大多数女性饮酒量为轻度和中度。我们队列中低度和中度饮酒者的数量使我们能够识别妊娠期间低度和中度酒精暴露的影响，以及高水平饮酒、滥用和酗酒的影响。拥有跨使用范围的数据还使我们能够定义 PAE 与结果之间的关系形状，并探索这些关联是否最好建模为剂量反应或阈值关系。这个提议是分析后代22岁时的后代及其母亲的数据。我们将确定22岁时PAE的影响，并将22年的评估与之前的10个阶段结合起来，看看PAE的轨迹从妊娠期到婴儿期、儿童期、青春期和成年早期的发育。公共卫生相关性：产前接触酒精对中枢神经系统的发育、生长和形态有显着影响。在高浓度的暴露下，这三个领域的影响会导致胎儿酒精综合症。人们对妊娠期间接触较低水平酒精的影响知之甚少。该提案旨在确定低度、中度以及大量产前酒精暴露的影响。