PRENATAL MARIJUANA EXPOSURE: LONG-TERM OUTCOMES

产前吸食大麻：长期结果

• 批准号: 7018517
• 负责人: NANCY Lee DAY
• 金额: $ 47.82万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-02-15 至 2010-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7018517
• 关键词: Cannabis; academic achievement; behavioral /social science research tag; clinical research; cognition; embryo /fetus toxicology; family structure /dynamics; growth /development; human subject; interview; longitudinal human study; marijuana abuse; neuropsychology; patient oriented research; questionnaires; socioeconomics; substance abuse epidemiology; substance abuse related behavior; substance abuse related disorder

DESCRIPTION (provided by applicant): The Maternal Health Practices and Child Development Project provides a unique opportunity to assess the development and maturation of young adults who have been followed since their fourth month of gestation through the age of 16. At this proposed phase, the offspring will be 21 years of age. We will explore the effects of prenatal marijuana exposure (PME) on the offspring in young adulthood. We will integrate this assessment with measures at prior phases and evaluate the developmental trajectories of these young adults across the multiple time points of the study. Importantly, at this proposed phase, we will assess the effects of prenatal exposure to marijuana on the transition into and adjustment to the roles and responsibilities of adulthood. The women in this project were interviewed in their fourth and seventh prenatal months and with their offspring at delivery, birth, 8 and 18 months, 3, 6, 10, 14 and 16 years of age. The cohort was selected from a prenatal clinic and the women represent the spectrum of prenatal marijuana use. At each of the 10 phases, we measured demographic status, the psychological, social, and household environment, maternal, paternal, and household substance use. We assessed the children's cognitive, behavioral, academic, psychological, physical, and neuropsychological status, and substance use and abuse. Study results to date demonstrate that marijuana exposure during gestation affects the development of the CNS, resulting in problems with mood, response suppression, and aspects of executive function. These outcomes, as well as the sequelae of these effects, such as academic difficulties and externalizing behaviors, may lead to more serious problems in adulthood. The deficits that result from prenatal exposure to marijuana have important implications for long-term development.

描述（由申请人提供）：孕产妇健康实践和儿童发展项目提供了一个独特的机会来评估从怀孕第四个月到 16 岁的年轻人的发展和成熟。在这个拟议阶段，后代将年满21岁。我们将探讨产前大麻暴露（PME）对成年早期后代的影响。我们将把这一评估与之前阶段的措施结合起来，并评估这些年轻人在研究的多个时间点的发展轨迹。重要的是，在这个拟议阶段，我们将评估产前接触大麻对成年期角色和责任的过渡和调整的影响。 该项目中的妇女在产前第四个月和第七个月以及她们的后代在分娩、出生、8 个月和 18 个月、3、6、10、14 和 16 岁时接受了采访。该队列是从产前诊所中选出的，这些女性代表了产前大麻使用的范围。在这 10 个阶段的每个阶段，我们测量了人口状况、心理、社会和家庭环境、母亲、父亲和家庭物质使用情况。我们评估了儿童的认知、行为、学业、心理、身体和神经心理状态，以及药物使用和滥用情况。 迄今为止的研究结果表明，妊娠期间接触大麻会影响中枢神经系统的发育，导致情绪、反应抑制和执行功能方面的问题。这些结果以及这些影响的后遗症，例如学业困难和外化行为，可能会导致成年后出现更严重的问题。产前接触大麻导致的缺陷对长期发育具有重要影响。