Advanced Imaging and Dosimetry Core

先进的成像和剂量测定核心

基本信息

批准号：
10672961
负责人：
Bryan Patrick Bednarz
金额：
$ 28.87万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-14 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10672961
关键词：
3-Dimensional Animals Bioinformatics Biometry Calibration Cancer Center Cancer Model Clinical Collaborations Combined Modality Therapy Communities Computational algorithm Computer software Data Dedications Deposition Discipline of Nuclear Medicine Dose Drug Kinetics Emission-Computed Tomography Ensure Equipment Experimental Designs Funding Goals Human Image Image Analysis Immunologic Stimulation Immunologics Immunosuppression Immunotherapy Individual Infrastructure Lead Leadership Magnetic Resonance Malignant Neoplasms Maps Medical Medical Research Modeling Molecular Target National Cancer Institute Normal tissue morphology Patient Selection Patient-Focused Outcomes Patients Pharmaceutical Preparations Physics Positron-Emission Tomography Process Production Protocols documentation Publications Quality Control Radiation therapy Radiochemistry Radioisotopes Radionuclide therapy Radiopharmaceuticals Renaissance Reporting Research Research Personnel Resources Rodent Scanning Services Therapeutic Time Toxic effect Translating Treatment Efficacy Tumor Tissue Uncertainty United States Food and Drug Administration University of Wisconsin Comprehensive Cancer Center University resources Wisconsin X-Ray Computed Tomography absorption animal imaging clinical translation companion animal cost efficient dosimetry drug distribution experience imaging facilities immunomodulatory strategy immunoregulation improved individualized medicine next generation operation optical imaging professor quality assurance quantitative imaging response symposium synergism theranostics treatment planning treatment response tumor tumor microenvironment

项目摘要

PROJECT SUMMARY The Advanced Imaging and Dosimetry Core (AIDC) provides the infrastructure, resources, and expertise required to facilitate quantitative multiscale imaging and dosimetry calculations, which are required to optimally synergize the combination of molecular targeted radionuclide therapy (TRT) and immunotherapy (ImmRx). The AIDC is a centralized dosimetry service that will ensure consistent scientific rigor and dosimetry reporting across each of the Projects of this PO1 proposal, entitled “Molecular targeted radionuclide therapy for tumor immunomodulation and enhancing immunotherapy response”. Furthermore, the significance of centralizing this process for each Project is the tremendous gain in efficiency that are achieved, ultimately saving individual investigators time and effort. Additionally, the AIDC will expand the leadership and operation of the Small Animal Imaging and Radiotherapy Facility (SAIRF) by offering support in all stages of the imaging and TRT dosimetry process, including calibration, experimental design, image acquisition optimization, pharmacokinetic profiling and modeling, micro-and macroscopic 3D dose calculations, and treatment response assessment. The AIDC will emphasize quality assurance and quality control in all aspects of the imaging and dosimetry process so that results are validated for application to the FDA. The AIDC will collaborate closely with the Radionuclide Production and Radiochemistry Core (RPRC) for dose calibration and traceability of the radiopharmaceuticals; and, the AIDC will collaborate with the Biostatistics and Bioinformatics Core (BBC) to help interpret imaging and dosimetry findings to validate response assessment. Lastly, the AIDC will help investigators disseminate their findings to the scientific community through publications and conference presentations. Renowned experts in the field of TRT dosimetry, Professor Bryan Bednarz and Joseph Grudzinski, will lead administrative and technical efforts, respectively.

项目概要高级成像和剂量测定核心 (AIDC) 提供基础设施、资源和专业知识需要促进定量多尺度成像和剂量测定计算，这是最佳地要求的分子靶向放射性核素治疗（TRT）和免疫治疗（ImmRx）的组合具有协同作用。 AIDC 是一项集中式剂量测定服务，将确保跨领域的科学严谨性和剂量测定报告的一致性该 PO1 提案的每个项目的标题为“肿瘤的分子靶向放射性核素治疗” 此外，集中化这一点的意义每个项目的流程都是所实现的效率的巨大提高，最终节省了个人成本此外，AIDC 将扩大小动物的领导和运作。成像和放射治疗设施 (SAIRF)，在成像和 TRT 剂量测定的所有阶段提供支持过程，包括校准、实验设计、图像采集优化、药代动力学分析建模、微观和宏观 3D 剂量计算以及治疗反应评估。 AIDC将强调成像和剂量测定过程各个方面的质量保证和质量控制以便对结果进行验证，以便向 FDA 申请。AIDC 将与放射性核素密切合作。用于放射性药物剂量校准和可追溯性的生产和放射化学核心（RPRC）；并且，AIDC 将与生物统计学和生物信息学核心 (BBC) 合作，帮助解释成像和最后，AIDC 将帮助研究人员传播他们的剂量测定结果。通过出版物和会议演讲向科学界展示研究成果。 TRT 剂量测定领域的 Bryan Bednarz 教授和 Joseph Grudzinski 教授将领导行政和分别进行技术努力。