Impact of host iron status on growth and viability of erythrocytic stages of Plas

宿主铁状态对 Plas 红细胞阶段生长和活力的影响

• 批准号: 7687076
• 负责人: Carla Cerami
• 金额: $ 20.47万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-20 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7687076
• 关键词: Affect; Age; Area; Biological Assay; Biological Availability; Cessation of life; Chelating Agents; Child; Classification; Clinical Trials; Country; Development; Developmental Delay Disorders; Erythrocytes; Folic Acid; Growth; Growth and Development function; Healthcare; Human; Hypoxanthines; Immune response; Immune system; In Vitro; Individual; Infection; Invaded; Iron; Iron Chelating Agents; Iron deficiency anemia; Malaria; Morbidity - disease rate; Mus; Nutrient; Organism; Parasitemia; Parasites; Patients; Pemba; Perinatal mortality demographics; Placenta; Plague; Plasmodium falciparum; Policies; Pregnancy; Pregnant Women; Preschool Child; Publishing; Regulation; Risk; Serum; Staging; Supplementation; Woman; Zanzibar; base; cytotoxic; evidence base; in vivo; micronutrient deficiency; parasite invasion; programs; public health relevance; response; transmission process

DESCRIPTION (provided by applicant): Iron deficiency is one of the most common micronutrient deficiencies in the world in pregnant women and children and it causes increased risk of perinatal mortality, morbidity and developmental delay. Recent evidence has suggested that iron deficiency may protect against malaria. Thus, the wisdom of universal supplementation in areas of the world where malaria is endemic has come under scrutiny. This application will attempt to identify the mechanism by which the human host's iron status affects the P. falciparum parasite in vitro. Specifically, we will determine if the growth, maturation and invasion rate of P. falciparum parasites is reduced in red blood cells and/or serum from severely iron deficient individuals before and after iron supplementation. The results will contribute to efforts to develop evidence-based iron supplementation policies in malaria-endemic areas. PUBLIC HEALTH RELEVANCE: Iron deficiency affects over 500 million people including many pregnant women and children from areas of the world that are plagued by malaria. It has been suggested that iron deficiency protects against malaria and questions have been raised about the risks associated with the universal iron supplementation programs in countries where malaria is endemic. In the proposed project, we will determine whether the growth and development of the malaria parasite is impacted by the host iron status in vitro. We will use RBC and sera from patients with severe iron deficiency anemia to look at this question in a very systematic way. This study will provide information for or against a possible mechanism by which iron deficiency may affect the malaria parasite. Ultimately, this information will provide additional evidence for the determination of policy on iron supplementation in malaria endemic regions.

描述（由申请人提供）：铁缺乏症是孕妇和儿童中世界上最常见的微量营养素缺陷之一，它会增加围产期死亡率，发病率和发育延迟的风险。最近的证据表明，铁缺乏症可以预防疟疾。因此，在疟疾流行的世界地区普遍补充的智慧受到了审查。该应用将尝试确定人类宿主在体外影响恶性疟原虫寄生虫的机制。具体而言，我们将确定在补充铁中和之后，红细胞和/或血清中，恶性疟原虫寄生虫的生长，成熟和侵袭率是否降低。结果将有助于制定疟疾流行病地区的基于证据的铁补充政策。 公共卫生相关性：铁缺乏影响超过5亿人，包括许多孕妇和来自疟疾困扰的地区的儿童。有人提出，铁缺乏症可以预防疟疾，并提出了有关与疟疾流行的国家中普遍补充铁的风险相关的风险。在拟议的项目中，我们将确定疟原虫的生长和发育是否受到体外宿主铁的影响。我们将使用严重缺乏铁缺乏贫血患者的RBC和血清以非常系统的方式来研究这个问题。这项研究将为铁缺乏症可能影响疟原虫的可能机制提供信息。最终，这些信息将为确定疟疾特有地区补充铁的政策提供其他证据。