Collaborative Pediatric Critical Care Research Network - Clinical Site

儿科重症监护协作研究网络 - 临床网站

基本信息

批准号：
10670278
负责人：
MICHAEL J BELL
金额：
$ 9.04万
依托单位：
UNIVERSITY OF UTAH
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-13 至 2026-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10670278
关键词：
Acute Admission activity Affect Antibiotics Area Ascorbic Acid Biological Markers Brain Cardiac Chest Child Child Development Child Health Childhood Clinical Research Clinical Trials Collaborations Communities Contracts Critical Care Critical Illness Critically ill children Data Data Coordinating Center Delirium Development District of Columbia Enrollment Ensure Faculty Family Funding Goals Good Clinical Practice Guideline Adherence Health Healthcare Systems Hospitals Human Resources Hypoxemic Respiratory Failure Individual Inflammation Injury Institution Lead Maryland Measures Mechanics Medicine Morbidity - disease rate Multicenter Studies Multiple Organ Failure Neurologic Nitric Oxide Observational Study Organ Organ failure Outcome Oxygen Patient Care Patients Pediatric Hospitals Performance Personal Satisfaction Principal Investigator Procedures Productivity Protocols documentation Public Health Quality of life Randomized, Controlled Trials Recovery Research Research Personnel Research Proposals Research Training Resources Running Scientist Sedation procedure Sepsis Sickle Cell Anemia Site Sleep Specialist Standardization Supportive care T cell regulation Talents Testing Training Traumatic Brain Injury Virginia Washington Work burden of illness career clinical care clinical center clinical research site design disability expectation experience functional outcomes functional status health assessment health related quality of life immunoregulation improved improved outcome innovation meetings member mortality novel strategies novel therapeutic intervention outcome prediction participant enrollment pediatric sepsis pediatric trauma pediatric traumatic brain injury personalized medicine research study skills success systematic review

项目摘要

PROJECT SUMMARY/ABSTRACT – Children’s National Hospital Discovery of new therapeutic approaches to save the lives and improve the recovery of children with critical illnesses can have profound effects on the child, the family and the overall health care system. In the past decades, studies – often from a single center or a small number of centers - have led to intriguing hypotheses that may result in benefits for a wide number of conditions. However, fully testing these putative therapies has been hampered by an inability to enroll adequate number of subjects, mobilize sufficient trained personnel to conduct the study and garner enough resources to fully answer the question. Children’s National Hospital (CNH) is enthusiastic to join the new Collaborative Pediatric Critical Care Network (CPCCRN) to perform the innovative studies for children with multiple organ failure after sepsis. CNH has been proud to be a part of the 3 previous CPCCRN cycles starting in 2004. As a clinical center with over 4000 ICU admissions each year while serving a diverse community in the Washington/Maryland/Virginia region, we stand uniquely poised to enroll subjects in innovative clinical studies. By including children from our center, from our ancillary site (Children’s Hospital of Richmond [CHoR]) and the other 22 sites within this new CPCCRN, sufficient numbers of children will be available for enrollment and ensure the generalizability of the findings. We bring an experienced research team to this new project. Our PI team is experienced at research, specialists in neurological and cardiac critical care and leaders at CNH. In these capacities, they will identify and support young investigators to participate in CPCCRN activities while also ensuring the success of the project(s) within CPCCRN. The PIs have been deeply involved with the preliminary studies that have led up to the proposed studies of personalized medicine to treat children with multiple organ failure. We believe this novel approach will finally advance the field past the hurdle of only being able to use “supportive” care for such patients and lead to substantial improvements in overall function, quality of life and family functioning. Moreover, we believe that new, funded projects can be brought into CPCCRN by investigators within our center to make further advances in the field of pediatric critical care.

项目摘要/摘要——国立儿童医院发现新的治疗方法来拯救生命并改善危重儿童的康复过去，痛苦会对儿童、家庭和整个医疗保健系统产生深远的影响。几十年来，研究——通常来自一个中心或少数几个中心——得出了有趣的假设这可能会对多种疾病产生益处，但是，对这些假定的疗法进行了充分测试。由于无法招募足够数量的受试者而受到阻碍，动员了足够的训练有素的人员进行研究并收集足够的资源来充分回答国家儿童医院 (CNH) 的问题。热衷于加入新的协作儿科重症监护网络 (CPCCRN) 来执行创新针对脓毒症后多器官衰竭儿童的研究。 CNH 很荣幸能够参与自 2004 年开始的前 3 个 CPCCRN 周期。每年有超过 4000 名 ICU 入院，同时为华盛顿/马里兰/弗吉尼亚州的多元化社区提供服务通过将我们的儿童纳入其中，我们处于独特的地位，可以将受试者纳入创新的临床研究。中心，从我们的辅助站点（里士满儿童医院 [CHoR]）和这个新的其他 22 个站点 CPCCRN，将有足够数量的儿童可供入学，并确保该项目的普遍适用性我们为这个新项目带来了一支经验丰富的研究团队，我们的 PI 团队在研究、神经和心脏重症监护领域的专家以及 CNH 的领导者将在这些职位上识别和领导。支持年轻研究者参与 CPCCRN 活动，同时确保项目的成功 CPCCRN 内部的 PI 深入参与了导致该项目的初步研究。我们相信这篇小说提出了治疗多器官衰竭儿童的个性化医学研究。该方法最终将推动该领域克服只能对此类患者使用“支持”护理的障碍并导致整体功能、生活质量和家庭功能的实质性改善。相信我们中心的研究人员可以将新的资助项目引入 CPCCRN，以进一步取得进展儿科重症监护领域的进展。