COGNITIVE & PHARMACOLOGICAL MODULATION OF HUMAN NEUROENDOCRINE STRESS AXIS-CRH

认知的

基本信息

批准号：
7603756
负责人：
James L Abelson
金额：
$ 2.33万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-03-01 至 2007-09-16
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7603756
关键词：
Adrenal Glands Affect Age-Years Anxiety Base of the Brain Behavior Blood specimen Brain Chemicals Clinical Research Cognitive Computer Retrieval of Information on Scientific Projects Database Corticotropin Corticotropin-Releasing Hormone Development Disease Dose Feeling Funding Gland Grant Hormones Hospitals Hour Human Hydrocortisone Institution Instruction Intravenous Measures Mental Depression Mental disorders Michigan Modeling Neurosecretory Systems Participant Pharmaceutical Preparations Pituitary Gland Pituitary Hormones Placebos Psychological Factors Research Research Personnel Research Project Grants Resources Role Source Stress System Thinking United States National Institutes of Health Universities Upper arm Veins Work biological adaptation to stress coping improved interest response stress management stress related disorder stressor

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This research project will contribute to our understanding of how the brain regulates the hormones and behaviors involved in our responses to stress. We will also be exploring the role of psychological factors that might affect the release of stress hormones from the pituitary and adrenal glands. Participants will be a group of healthy people who do not have any particular problems with anxiety, depression, or stress-related disorders. There will be about 30 subjects between 18 and 45 years of age, who are medically healthy and are not taking medication or drugs. Subjects will be admitted on two afternoons to the General Clinical Research Center at the University of Michigan Hospital. They will have an intravenous line in place in a vein in their arm for about 5 hours. We will draw blood samples through this line and will also use it to give them either a dose of a hormone called corticotropin-releasing hormone (CRH) or a placebo (inactive substance). CRH is a brain chemical that provides primary control over the release of the stress hormones we are interested in, by directly stimulating the release of another hormone (adrenocorticotropin) from the pituitary gland, which is an important gland located at the base of the brain. We will be measuring both adrenocorticotropin and cortisol, both of which are released by people when attempting to cope with a challenge or stressor. We will be using different types of instructions to also study how thoughts and feelings can affect release of these hormones. Which instructions subjects receive will be determined randomly. The study may help us better understand the role of psychological factors in human stress response systems. We hope this work will contribute to the development of improved approaches to the management of stress. We also hope that it will help us to develop models that will be useful in studying the human stress response system in different psychiatric disorders and perhaps help us search for the causes of some of these disorders.'

该子项目是利用该技术的众多研究子项目之一资源由 NIH/NCRR 资助的中心拨款提供。子项目及研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金，因此可以在其他 CRISP 条目中表示。列出的机构是对于中心来说，它不一定是研究者的机构。该研究项目将有助于我们了解大脑如何调节与压力反应有关的激素和行为。我们还将探索可能影响垂体和肾上腺释放应激激素的心理因素的作用。参与者将是一群健康的人，没有任何特定的焦虑、抑郁或压力相关疾病问题。大约有 30 名年龄在 18 岁至 45 岁之间的受试者，他们身体健康，没有服用药物或药物。受试者将在两个下午进入密歇根大学医院的综合临床研究中心。他们将在手臂静脉中放置静脉注射管约 5 小时。我们将通过这条线抽取血液样本，并用它给他们注射一剂叫做促肾上腺皮质激素释放激素（CRH）的激素或安慰剂（非活性物质）。 CRH 是一种大脑化学物质，通过直接刺激垂体（位于大脑底部的一个重要腺体）释放另一种激素（促肾上腺皮质激素），对我们感兴趣的应激激素的释放提供主要控制。我们将测量促肾上腺皮质激素和皮质醇，这两种物质都是人们在试图应对挑战或压力时释放的。我们将使用不同类型的指导来研究思想和感受如何影响这些激素的释放。受试者接受哪些指令将被随机确定。这项研究可能有助于我们更好地了解心理因素在人类压力反应系统中的作用。我们希望这项工作将有助于开发改进的压力管理方法。我们还希望它能帮助我们开发模型，用于研究不同精神疾病中的人类应激反应系统，并可能帮助我们寻找其中一些疾病的原因。