Stress Biomarkers: Biological Meaning of Field-Friendly Salivary Measures
压力生物标志物:现场友好唾液测量的生物学意义
基本信息
- 批准号:9094617
- 负责人:
- 金额:$ 54.34万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-07-01 至 2018-10-31
- 项目状态:已结题
- 来源:
- 关键词:AccountingAdrenal GlandsAreaBiologicalBiological AssayBiological MarkersBiological ProcessBiologyBrainCRH geneCardiovascular DiseasesChildhoodCollectionCorticotropinCorticotropin-Releasing Hormone ReceptorsDataDetectionDevelopmental ProcessDexamethasoneDistantDocumentationEmotionsEpidemiologic StudiesEpidemiologyExplosionFailureFatigueFeedbackFosteringFutureGenesGeneticGlucocorticoidsGoalsHealthHumanHydrocortisoneHypothalamic structureLaboratoriesLaboratory StudyLeadLife StressLightLinkMalignant NeoplasmsMeasurableMeasuresMediator of activation proteinMental DepressionMental HealthMetabolic DiseasesMetyraponeMinorityMorbidity - disease rateNeurobiologyOccupationsOutcomePituitary GlandPlayPriceProcessPsychosocial FactorPsychosocial InfluencesPsychosocial StressReceptor GeneRecoveryRegulationResearchResearch PersonnelResistanceRiskRoleSalivaSalivarySamplingShapesStressSystemTestingTranslatingTraumaVariantWorkbasecostcost effectivedevelopmental geneticsdexamethasone suppression testexperiencefield studygenetic informationgenetic varianthypothalamic-pituitary-adrenal axisinterestmortalitynovelpediatric traumaphysical conditioningpreventpsychosocialpublic health relevancereceptor sensitivityrelating to nervous systemresponserisk variantsocioeconomicsstress reactivitytrait
项目摘要
DESCRIPTION (provided by applicant): Stress and emotion impact health. To reduce their costly health consequences, mechanisms through which they alter biological processes must be understood. The hypothalamic-pituitary adrenal (HPA) axis plays a key role in transducing psychosocial experience into bodily changes relevant to health, and HPA stress research is exploding. Salivary cortisol measures provide a stress "biomarker" of HPA activity for use in epidemiological studies, revealing that cortisol is associated with job stress, trauma, depression, fatigue, minority status, cardiovascular disease, and cancer mortality. Laboratory work has dissected HPA activity into biologically important regulatory components (e.g., negative feedback, central drive, stress reactivity) and provides laboratory probes of these components, but there has been little effort to link field and laboratory studies. Psychosocial correlates of field-friendly stress biomarkers are being identified, but we know little about their biological meaning. Markers have been chosen based on ease of use, not on empirical links to specific biological processes of known health relevance. This project will link field and laboratory work, enhancing the value of both, and the value derived from the millions of dollars spent yearly on salivary cortisol assay. The cortisol awakening response (CAR), awakening level, and diurnal decline are commonly used field stress biomarkers. Each likely provides different information about HPA axis regulation, but this has not been explicitly examined. CAR is the most extensively used. Its laboratory correlates have been studied, but are rarely acknowledged - it appears more closely linked to adrenal sensitivity than to theoretically more interesting central HPA measures. Giving biological meaning to field-friendly biomarkers will foster more precise hypotheses, and more efficient bio-sampling to test them. The laboratory probes which will attach biological meaning to salivary measures are themselves influenced by interacting genetic and developmental factors. Childhood adversity, for example, significantly reduces HPA feedback sensitivity, but this effect is only seen in subjects with a particular variant of an HPA gene (CRHR1) and can remain undetected if the genetic effect is ignored. If genes impact laboratory probes, and the field markers link to these probes, genes will impact the field markers. Ignoring this impact will undermine efforts to link psychosocial variables to the stress biomarkers. Documentation of this phenomena and preliminary exploration of relevant genes will be critical to prevent false negative results and replication failures in expensive epidemiological studies that we hope will use the more efficient and biologically meaningful biomarkers we identify in this project. In this study, we will use laboratory probes to give biological meaning to field-friendly HPA biomarkers, identify the most efficient and meaningful set of probes to use, and provide preliminary data on genetic factors that can undermine hypothesis testing in epidemiological stress research using stress biomarkers. This work will deepen understanding of the HPA axis and enhance the value of every future dollar spent on field stress studies.
描述(由申请人提供):压力和情绪影响健康。为了减少其昂贵的健康后果,必须理解它们改变生物学过程的机制。下丘脑 - 垂体肾上腺(HPA)轴在将社会心理经历转换为与健康相关的身体变化方面起着关键作用,HPA压力研究正在爆炸。唾液皮质醇度量为流行病学研究提供了HPA活性的压力“生物标志物”,表明皮质醇与工作压力,创伤,抑郁,疲劳,少数群体状态,心血管疾病和癌症死亡率有关。实验室工作已将HPA活性剖分为生物学上重要的调节组件(例如,负反馈,中心驱动,压力反应性),并提供了这些组件的实验室探针,但是几乎没有努力将现场和实验室研究联系起来。正在识别出对现场友好的压力生物标志物的社会心理相关性,但我们对它们的生物学意义知之甚少。已经根据易用性选择了标记,而不是与已知健康相关性的特定生物学过程的经验联系。该项目将链接现场和实验室工作,增强两者的价值以及每年在唾液皮质醇测定上花费的数百万美元的价值。皮质醇觉醒反应(CAR),觉醒水平和昼夜下降是常用的场应力生物标志物。每个都可能提供有关HPA轴调节的不同信息,但尚未明确检查。汽车是最广泛使用的。它的实验室相关性已经进行了研究,但很少得到认可 - 它似乎与肾上腺敏感性更紧密相关,而不是与理论上更有趣的中央HPA措施相关。对现场友好的生物标志物赋予生物学意义将促进更精确的假设,并更有效地进行生物采样来测试它们。将生物学意义与唾液措施相互作用的实验室探针本身受到相互作用的遗传和发育因素的影响。例如,儿童逆境大大降低了HPA的反馈敏感性,但是这种效应仅在具有HPA基因的特定变体(CRHR1)的受试者中可以看到,并且如果忽略遗传效应,则可能仍未发现。如果基因影响实验室探测器,并且现场标记与这些探针联系在一起,则基因将影响现场标记。忽略这种影响将破坏将心理社会变量与压力生物标志物联系起来的努力。这种现象的记录和相关基因的初步探索对于防止昂贵的流行病学研究中的虚假负面结果和复制失败至关重要,我们希望我们能使用我们在该项目中识别的更有效且对生物学上有意义的生物标志物。在这项研究中,我们将使用实验室探针为现场友好的HPA生物标志物提供生物学意义,确定最有效,最有意义的探针集,并提供有关遗传因素的初步数据,这些数据可以破坏使用压力生物标志物在流行病学压力研究中破坏假设测试的假设测试。这项工作将加深对HPA轴的理解,并增强在现场压力研究上花费的每一美元的价值。
项目成果
期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
The psychology of HPA axis activation: Examining subjective emotional distress and control in a phobic fear exposure model.
- DOI:10.1016/j.psyneuen.2017.02.001
- 发表时间:2017-08
- 期刊:
- 影响因子:3.7
- 作者:Mayer SE;Snodgrass M;Liberzon I;Briggs H;Curtis GC;Abelson JL
- 通讯作者:Abelson JL
Do diurnal salivary cortisol curves carry meaningful information about the regulatory biology of the HPA axis in healthy humans?
每日唾液皮质醇曲线是否携带有关健康人类 HPA 轴调节生物学的有意义的信息?
- DOI:10.1016/j.psyneuen.2023.106031
- 发表时间:2023
- 期刊:
- 影响因子:3.7
- 作者:Abelson,JamesL;Sánchez,BrisaN;Mayer,StefanieE;Briggs,Hedieh;Liberzon,Israel;Rajaram,Nirmala
- 通讯作者:Rajaram,Nirmala
Context Processing and the Neurobiology of Post-Traumatic Stress Disorder.
- DOI:10.1016/j.neuron.2016.09.039
- 发表时间:2016-10-05
- 期刊:
- 影响因子:16.2
- 作者:Liberzon I;Abelson JL
- 通讯作者:Abelson JL
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James L Abelson其他文献
James L Abelson的其他文献
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{{ truncateString('James L Abelson', 18)}}的其他基金
Glucocorticoid modulation of contextual processing and its neurocircuitry: Testing a new model of PTSD pathophysiology
糖皮质激素对情境处理及其神经回路的调节:测试 PTSD 病理生理学的新模型
- 批准号:
10358975 - 财政年份:2018
- 资助金额:
$ 54.34万 - 项目类别:
Glucocorticoid modulation of contextual processing and its neurocircuitry: Testing a new model of PTSD pathophysiology
糖皮质激素对情境处理及其神经回路的调节:测试 PTSD 病理生理学的新模型
- 批准号:
9757830 - 财政年份:2018
- 资助金额:
$ 54.34万 - 项目类别:
Glucocorticoid modulation of contextual processing and its neurocircuitry: Testing a new model of PTSD pathophysiology
糖皮质激素对情境处理及其神经回路的调节:测试 PTSD 病理生理学的新模型
- 批准号:
9521159 - 财政年份:2018
- 资助金额:
$ 54.34万 - 项目类别:
Glucocorticoid modulation of contextual processing and its neurocircuitry: Testing a new model of PTSD pathophysiology
糖皮质激素对情境处理及其神经回路的调节:测试 PTSD 病理生理学的新模型
- 批准号:
10227772 - 财政年份:2018
- 资助金额:
$ 54.34万 - 项目类别:
Stress Biomarkers: Biological Meaning of Field-Friendly Salivary Measures
压力生物标志物:现场友好唾液测量的生物学意义
- 批准号:
8683236 - 财政年份:2012
- 资助金额:
$ 54.34万 - 项目类别:
Stress Biomarkers: Biological Meaning of Field-Friendly Salivary Measures
压力生物标志物:现场友好唾液测量的生物学意义
- 批准号:
8234483 - 财政年份:2012
- 资助金额:
$ 54.34万 - 项目类别:
Stress Biomarkers: Biological Meaning of Field-Friendly Salivary Measures
压力生物标志物:现场友好唾液测量的生物学意义
- 批准号:
8488480 - 财政年份:2012
- 资助金额:
$ 54.34万 - 项目类别:
Stress Biomarkers: Biological Meaning of Field-Friendly Salivary Measures
压力生物标志物:现场友好唾液测量的生物学意义
- 批准号:
8875759 - 财政年份:2012
- 资助金额:
$ 54.34万 - 项目类别:
Effects of comorbid anxiety disorders on the HPA axis profile of depression
共病焦虑症对抑郁症 HPA 轴特征的影响
- 批准号:
8206733 - 财政年份:2008
- 资助金额:
$ 54.34万 - 项目类别:
Effects of comorbid anxiety disorders on the HPA axis profile of depression
共病焦虑症对抑郁症 HPA 轴特征的影响
- 批准号:
8007421 - 财政年份:2008
- 资助金额:
$ 54.34万 - 项目类别:
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