INTEGRATED MICROFLUIDIC SYSTEM FOR ORAL DIAGNOSTICS

用于口腔诊断的集成微流体系统

• 批准号: 7603779
• 负责人: WILLIAM V GIANNOBILE
• 金额: $ 12.04万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7603779
• 关键词: Adult; Affect; Anti-Inflammatory Agents; Anti-inflammatory; Antibiotics; Aspirin; Biological; Collection; Computer Retrieval of Information on Scientific Projects Database; Dental; Depth; Diagnosis; Disease; Film; Funding; Gingival Crevicular Fluid; Grant; Ibuprofen; Institution; Liquid substance; Measurement; Medical; Metabolic Bone Diseases; Microfluidics; Oral; Oral cavity; Paper; Patients; Periodontitis; Pharmaceutical Preparations; Population; Postmenopausal Osteoporosis; Purpose; Recording of previous events; Research; Research Personnel; Resources; Rheumatoid Arthritis; Saline; Saliva; Sampling; Sodium Chloride; Source; System; Testing; Time; Tissues; Tooth structure; Tube; United States National Institutes of Health; Visit; Water; disorder risk; instrument; oral diagnostics; scaling and root planing

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is being conducted to test the ability and accuracy of a new instrument in the diagnosis of periodontitis (gum disease) by using fluids from the mouth. The diagnosis instrument will test two types of fluids, gingival crevicular fluid (GCF) and saliva. GCF is the fluid that accumulates between your teeth and gum tissue. The fluids will be collected in three ways: 1. Direct GCF sampling: Thin paper films will be inserted into the space between the teeth and gums to absorb the fluid; 2. GCF rinse sampling: The patient will rinse with saline solution (water with salt content concentration similar to biological fluids) and spit into a tube; 3. Whole saliva: The patient will spit saliva into a tube. A total of 100 adult patients will participate in this study. These subjects will be of two patient populations: 1) diseased population, with active gum disease; and 2) a low-risk disease population, with no active gum disease. All subjects will have at least 20 teeth and not have received periodontal treatment or antibiotic-related therapy for medical or dental reasons 3 months prior to study inclusion. Patients will also be excluded from the study if they receive long-term use of medications known to affect periodontal status such as anti-inflammatory drugs, aspirin, and ibuprofen. The patients will also possess no history of metabolic bone diseases such as rheumatoid arthritis or post-menopausal osteoporosis. Patients will be seen 6 times over the course of the study over a period of approximately 12 months. At each visit the patient will undergo oral fluid collection, as previously described, and thorough examinations of the mouth, including the taking of measurements for study purposes. Patients will also have CT/radiographs taken at baseline, month 6, and end of study visits. At the end of the oral fluid collection period subjects will receive a deep cleaning (scaling and root planing) or a regular cleaning (prophy), dependent upon patient s needs. '

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 这项研究的目的是测试一种新仪器利用口腔液体诊断牙周炎（牙龈疾病）的能力和准确性。 诊断仪器将测试两种类型的液体：龈沟液（GCF）和唾液。 GCF 是积聚在牙齿和牙龈组织之间的液体。 通过三种方式收集液体： 1. 直接 GCF 采样：将薄纸膜插入牙齿和牙龈之间的空间以吸收液体； 2.GCF冲洗取样：患者用生理盐水（含盐浓度与生物体液相似的水）冲洗并吐入试管中； 3. 全唾液：患者将唾液吐入管中。 共有100名成年患者将参与这项研究。 这些受试者属于两个患者群体：1）患有活动性牙龈疾病的患病群体； 2) 没有活动性牙龈疾病的低风险疾病人群。 所有受试者都至少有 20 颗牙齿，并且在研究纳入前 3 个月内未因医疗或牙科原因接受过牙周治疗或抗生素相关治疗。如果患者长期使用已知影响牙周状态的药物（例如抗炎药、阿司匹林和布洛芬），也将被排除在研究之外。患者也没有代谢性骨病史，例如类风湿性关节炎或绝经后骨质疏松症。 在大约 12 个月的研究过程中，患者将就诊 6 次。 每次就诊时，患者都将进行口腔液收集（如前所述），并对口腔进行彻底检查，包括出于研究目的进行测量。 患者还将在基线、第 6 个月和研究访视结束时进行 CT/X 光检查。 在口腔液收集期结束时，根据患者的需要，受试者将接受深度清洁（洗牙和根面平整）或定期清洁（洁牙）。 '