Antimicrobial resistance in Neisseria gonorrhoeae among men on PrEP in Vietnam

越南男性 PrEP 中淋病奈瑟菌的耐药性

• 批准号: 10667655
• 负责人: Paul C Adamson
• 金额: $ 19.16万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-23 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10667655
• 关键词: Address; Affect; Aftercare; Anatomy; Antibiotic Therapy; Antibiotic susceptibility; Antibiotics; Antimicrobial Resistance; Asia; Azithromycin; Bacteria; Behavioral; Bioinformatics; Biometry; Cefixime; Ceftriaxone; Cephalosporin Resistance; Cephalosporins; Clinical Data; Clinical Microbiology; Clinical Trials; Collaborations; Communicable Diseases; Consumption; DNA Sequence Alteration; Data; Detection; Diagnosis; Diagnostic; Elements; Epidemiology; Etiology; Europe; Frequencies; Future; Genetic; Genetic Markers; Genomics; Genotype; Goals; Gonorrhea; HIV; Infection; Injectable; International; Intervention; Knowledge; Link; Measures; Medical; Mentored Research Scientist Development Award; Mentors; Mentorship; Molecular Epidemiology; Neisseria; Neisseria gonorrhoeae; Oropharyngeal; Pharyngeal structure; Phenotype; Physicians; Population; Predisposition; Prevalence; Prevention Research; Public Health; Recommendation; Rectum; Reporting; Research; Research Infrastructure; Research Personnel; Resistance; Resistance development; Resistance to infection; Risk Factors; Sexually Transmitted Diseases; Testing; Training; Treatment Failure; Treatment outcome; United Kingdom; United Nations; Universities; Urethra; Vietnam; World Health Organization; antimicrobial; burden of illness; career; career development; cohort; drug-resistant gonorrhea; epidemiology study; experience; follow-up; genome sequencing; genomic epidemiology; global health; global health emergency; high risk; improved; low and middle-income countries; men; men who have sex with men; pharyngeal gonorrhea; pre-exposure prophylaxis; priority pathogen; programs; rectal; research study; study population; whole genome

PROJECT SUMMARY/ABSTRACT Antimicrobial resistance (AMR) is a global health emergency. Neisseria gonorrhoeae is a high-priority pathogen for AMR, as there are 87 million infections per year worldwide and the bacteria has demonstrated resistance to every class of antibiotics recommended for its treatment. Treatment failures have been reported, typically involve oropharyngeal infections, and are dire warnings that the era of untreatable gonorrhea is near. In the Western Pacific Region, which includes Vietnam, resistance to ceftriaxone and azithromycin, the most commonly recommended antibiotic therapy for gonorrhea, are increasing. Men who have sex with men (MSM) are disproportionately affected by AMR in N. gonorrhoeae infections, but remain under-represented in data from low- and middle-income countries (LMICs). The proposed study seeks to better understand AMR in N. gonorrhoeae by embedding new research into an existing HIV pre-exposure prophylaxis (PrEP) program for MSM in Vietnam. The study aims are 1) to determine the prevalence of and risk factors for AMR in N. gonorrhoeae among MSM in a PrEP program in Vietnam; 2) to measure the frequency of pharyngeal N. gonorrhoeae treatment failures and the association between pharyngeal infections and AMR; and 3) to use whole-genome sequencing (WGS) to conduct a genomic epidemiology study of N. gonorrhoeae nested within our study population of MSM in a PrEP program in Vietnam. The study will leverage regular testing for N. gonorrhoeae and follow-up that occur through the PrEP program to shed new light on the issue of AMR in N. gonorrhoeae within this key population. This Fogarty International Research Scientist Development Award (K01) is to support the career development of Dr. Paul Adamson, an infectious diseases physician whose goal is to become an independent global health investigator at the intersection of AMR and sexually transmitted infections (STIs). The K01 will support Dr. Adamson to develop expertise in 1) clinical microbiology and AMR testing, 2) WGS, bioinformatics, and genomic epidemiology, and 3) advanced training in clinical trials research with a focus in LMICs. To achieve the proposed research and training aims, Dr. Adamson has assembled a mentorship team with proven experience mentoring early-career investigators and with expertise in STIs, epidemiology, AMR, biostatistics, and genomics. Drs. Pamina Gorbach (UCLA) and Le Minh Giang (Hanoi Medical University, HMU) will serve as Primary Mentors and have extensive experience in conducting large-scale prevention research studies and clinical trials on STIs and HIV among MSM. In addition, his Co-Mentorship team includes Dr. Jeffrey Klausner, a US-based global health researcher and an international expert on STIs and AMR in N. gonorrhoeae, and Dr. Nguyen Vu Trung, a Vietnam-based researcher with expertise in clinical microbiology and antibiotic susceptibility testing in N. gonorrhoeae. The proposed research and training aims leverage the strong research collaborations and the robust research infrastructure that exist between UCLA and HMU. The IRSDA will advance Dr. Adamson's career as an expert in STIs and AMR and establish him as an independent global health investigator.

项目概要/摘要 抗菌素耐药性（AMR）是一个全球性的卫生紧急事件。淋病奈瑟菌是一种高度优先的病原体 对于 AMR，全球每年有 8700 万人感染，并且该细菌已表现出耐药性 推荐用于治疗的每一类抗生素。据报道治疗失败，通常涉及 口咽部感染，这是无法治愈的淋病时代即将到来的可怕警告。在西方 包括越南在内的太平洋地区对头孢曲松和阿奇霉素的耐药性是最常见的 推荐用于淋病的抗生素治疗，正在增加。男男性行为者 (MSM) 是 在淋病奈瑟菌感染中，AMR 的影响尤为严重，但在低水平的数据中代表性仍然不足。 和中等收入国家（LMIC）。拟议的研究旨在更好地了解淋病奈瑟菌的 AMR 将新研究纳入越南现有的针对 MSM 的 HIV 暴露前预防 (PrEP) 计划。 该研究的目的是 1) 确定 MSM 中淋病奈瑟菌 AMR 的患病率和危险因素 越南的 PrEP 项目； 2) 测量咽部淋病奈瑟菌治疗失败的频率 以及咽部感染与抗菌素耐药性之间的关联； 3) 使用全基因组测序 (WGS) 对嵌套在我们的 MSM 研究群体中的淋病奈瑟菌进行基因组流行病学研究 越南的 PrEP 计划。该研究将利用对淋病奈瑟菌的定期检测和后续跟踪 通过 PrEP 计划，为这一关键人群中淋病奈瑟菌的 AMR 问题提供新的线索。 福格蒂国际研究科学家发展奖（K01）旨在支持职业发展 保罗·亚当森 (Paul Adamson) 博士是一位传染病医生，他的目标是成为独立的全球卫生专家 AMR 和性传播感染 (STI) 交叉领域的调查员。 K01 将支持博士。 Adamson 将开发 1) 临床微生物学和 AMR 测试、2) WGS、生物信息学和基因组方面的专业知识 流行病学，3) 临床试验研究高级培训，重点关注中低收入国家。为了实现建议的 为了研究和培训目标，Adamson 博士组建了一支具有丰富指导经验的导师团队 早期职业研究人员，拥有性传播感染、流行病学、抗菌素耐药性、生物统计学和基因组学方面的专业知识。博士。 Pamina Gorbach（加州大学洛杉矶分校）和 Le Minh Giang（河内医科大学、HMU）将担任主要导师 并在开展大规模性传播感染预防研究和临床试验方面拥有丰富的经验 和男同性恋者中的艾滋病毒。此外，他的共同指导团队包括杰弗里·克劳斯纳 (Jeffrey Klausner) 博士，他是一位驻美国的全球 健康研究员、淋病奈瑟菌性传播感染和抗菌素耐药性国际专家，以及 Nguyen Vu Trung 博士， 一位驻越南的研究人员，拥有临床微生物学和新孢子虫抗生素敏感性测试方面的专业知识。 淋病。拟议的研究和培训目标利用了强有力的研究合作和 加州大学洛杉矶分校和 HMU 之间存在强大的研究基础设施。 IRSDA 将推动 Adamson 博士的职业生涯 作为性传播感染和抗菌素耐药性方面的专家，并将他确立为独立的全球健康调查员。

项目成果

Machine learning to predict ceftriaxone resistance using single nucleotide polymorphisms within a global database of Neisseria gonorrhoeae genomes.

使用淋病奈瑟菌基因组全球数据库中的单核苷酸多态性进行机器学习来预测头孢曲松耐药性。

• 发表时间: 2023-12-12
• 影响因子: 3.7
• 作者: Ha, Sung Min;Lin, Eric Y;Klausner, Jeffrey D;Adamson, Paul C
• 通讯作者: Adamson, Paul C

Screening for monkeypox virus infections in men who have sex with men in a sexual health clinic in Hanoi, Viet Nam.

越南河内一家性健康诊所对男男性行为者进行猴痘病毒感染筛查。

• 发表时间: 2023-04
• 作者: Adamson, Paul C;Bui, Hao Thi Minh;Kesteman, Thomas;Nguyen, Diep Thi Ngoc;Nguyen, Thuong Thi Hong;Van Le, Tan;van Doorn, Rogier H;Klausner, Jeffrey D;Le, Giang Minh
• 通讯作者: Le, Giang Minh

Endofungal Mycetohabitans rhizoxinica Bacteremia Associated with Rhizopus microsporus Respiratory Tract Infection.

真菌内真菌菌血症与小孢子菌呼吸道感染相关。

• 发表时间: 2022-10
• 影响因子: 11.8
• 作者: Yang, Shangxin;Anikst, Victoria;Adamson, Paul C
• 通讯作者: Adamson, Paul C

Prevalence and Factors Associated With Antigen Test Positivity Following SARS-CoV-2 Infection Among Health Care Workers in Los Angeles.

洛杉矶医护人员感染 SARS-CoV-2 后抗原检测阳性的患病率和相关因素。

• 发表时间: 2022-10
• 影响因子: 4.2
• 作者: Adamson, Paul C;Currier, Judith S;Uslan, Daniel Z;Garner, Omai B
• 通讯作者: Garner, Omai B

Resistance-Guided Therapy for Neisseria gonorrhoeae.

淋病奈瑟菌的耐药引导治疗。

• 发表时间: 2022-10-29
• 作者: Allan;Adamson, Paul C;Klausner, Jeffrey D
• 通讯作者: Klausner, Jeffrey D