Patient Oriented Research in Pediatric Motility and Related Disorders

以患者为中心的小儿运动及相关疾病研究

• 批准号: 7571019
• 负责人: SAMUEL NURKO
• 金额: $ 18.75万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7571019
• 关键词: Acids; Area; Award; Baclofen; Biological Assay; Biological Markers; Biological Markers; Biometry; Boston; Botox; Case-Control Studies; Cerebral Palsy; Characteristics; Child; Childhood; Circular layer of muscularis propria of anal canal; Clinical Research; Clinical Trials; Constipation; Data Analyses; Defecation; Disease; Disease Progression; Disease remission; Dose; Education; Enrollment; Eosinophilic Esophagitis; Epidemiology; Esophageal; Evaluation; Event; Foundations; Frequencies; Functional Gastrointestinal Disorders; Funding; Gastroesophageal reflux disease; Glycerol; Goals; Grant; Headache; Hypotension; IgE; Immunologics; Infant; Inflammation; Learning; Manuscripts; Mediating; Mentors; Mentorship; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Monitor; Nitric Oxide; Paste substance; Patients; Pediatric Hospitals; Placebos; Preparation; Public Health Schools; Reflux; Research; Research Personnel; Research Project Grants; Research Training; Safety; Secondary to; Structure; Symptoms; Tachycardia; Testing; Time; Training; base; career; cell motility; clinical efficacy; design; disease diagnosis; gastrointestinal symptom; implementation research; improved; insight; interest; novel; patient oriented research; placebo controlled study; pressure; programs; prospective; rectal

DESCRIPTION (provided by applicant): This application for a K24 Midcareer Investigator Award in Patient-Oriented Research is based on research and mentoring programs at the Center for Motility and Functional Gastrointestinal Disorders at Children's Hospital in Boston. The primary goal for this award is to provide protected time for mentoring in the setting of several ongoing patient-oriented research projects in pediatric motility and related disorders. One of the main objectives is to provide research training and mentorship for young investigators in this field. There are three main projects that are proposed in this application. One focuses on the treatment of non-acid reflux with the use of baclofen, the other on the use of nitric oxide paste to treat obstructive symptoms in patients with a nom-relaxing [sic] internal anal sphincter, and the third is a translational project that's is part of a boarder focus on the relation between inflammation and motility problems. This project is focused on finding new biomarkers for the evaluation of children with eosinophilic esophagitis. Trainees interested in pediatric motility and related disorders will be encouraged to become directly involved in these clinical research training opportunities. Structured mentoring is made available under my guidance, and trainees will become proficient in the technical aspects of performing motility testing in children, the design and implementation of research projects, analysis of the data, organization for presentation, as well as manuscript preparation. Trainees may enroll in coursework at the Harvard School of Public Health or similar programs to learn advanced education in epidemiology, biostatistics, and clinical investigation. Throughout their training years trainees will be prepared for academic careers. The K24 award will provide with essential support for the applicant to achieve his mentorship and research goals.

描述（由申请人提供）： 本次 K24 职业生涯中期研究员奖以患者为导向的研究申请基于波士顿儿童医院运动和功能性胃肠疾病中心的研究和指导项目。该奖项的主要目标是为几个正在进行的儿科运动和相关疾病的以患者为导向的研究项目提供受保护的指导时间。主要目标之一是为该领域的年轻研究人员提供研究培训和指导。本申请提出了三个主要项目。一个重点是使用巴氯芬治疗非胃酸反流，另一个重点是使用一氧化氮糊剂治疗肛门内括约肌正常松弛[原文如此]患者的阻塞症状，第三个是一个转化项目这是对炎症和运动问题之间关系的边界关注的一部分。该项目的重点是寻找新的生物标志物来评估患有嗜酸粒细胞性食管炎的儿童。将鼓励对儿科运动和相关疾病感兴趣的学员直接参与这些临床研究培训机会。在我的指导下提供结构化指导，学员将精通儿童运动测试、研究项目的设计和实施、数据分析、演示组织以及手稿准备等技术方面。学员可以报名参加哈佛大学公共卫生学院的课程或类似项目，以学习流行病学、生物统计学和临床​​调查方面的高级教育。在整个培训期间，学员将为学术生涯做好准备。 K24 奖项将为申请人实现其指导和研究目标提供必要的支持。