In Vivo Evaluation of Presbyopia

老花眼的体内评估

• 批准号: 7662104
• 负责人: KATHRYN RICHDALE
• 金额: $ 16.42万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7662104
• 关键词: Adult; Affect; Age; Agreement; Algorithms; Animal Model; Anterior; Area; Award; Biomedical Engineering; Body Size; Caliber; Choroid; Ciliary Body; Ciliary Muscle; Collaborations; Computers; Contracts; Crystalline Lens; Development; Dimensions; Elements; Enrollment; Etiology; Evaluation; Eye; Future; Goals; Human; Image; Image Analysis; Interdisciplinary Study; Iris; Lead; Life; Literature; Location; Magnetic Resonance Imaging; Mathematics; Measurement; Measures; Mechanics; Mentors; Modeling; Optical Coherence Tomography; Optics; Patients; Physiological; Play; Presbyopia; Process; Radiology Specialty; Research; Role; Scientist; Stimulus; Structure; System; Techniques; Testing; Thick; Time; Training; Ultrasonography; Variant; Vision research; Width; Work; base; career development; cohort; discounting; early onset; image processing; in vivo; insight; lens; loss of function; novel; programs; response; theories; tool

DESCRIPTION (provided by applicant): The goals of this BCD award are to: 1) train Kathryn Richdale, OD MS as an interdisciplinary clinician scientist and 2) further elucidate the structural and mechanical changes associated with presbyopia. One of the NIH's new Roadmap initiatives is to create interdisciplinary research teams that are more "analytically sophisticated" and will "yield fresh and unexpected insights;" this project will achieve that aim. A five-year career-development program is proposed, consisting of formal coursework and training in biomedical engineering, radiology, mathematics and computer-based image processing. There is still limited understanding of the ocular changes associated with presbyopia. Much of the previous work has focused on either the function of the lens or of the ciliary body, but has failed to provide a comprehensive view of the entire accommodative system. Previous research has been limited by the inability to visualize the internal structures of the human eye in vivo. Studies have been confounded by the use of animal models not entirely similar to humans; pharmacological agents known to affect the normal physiological response; post mortem changes inherent to the use of cadaveric eyes; and ex vivo work using nonphysiological forces and discounting the role of the iris, vitreous, and choroid. Presbyopia may likely be a multifactorial process, as no one mechanism is able to explain the early onset, continued linear decline, and complete loss of function. In order to test hypotheses that would support the lenticular theory and/or the extralenticular theory of presbyopia, we will image and analyze the accommodative structures in vivo in a cohort of human adults, and determine how those structures change with age and accommodative effort. Eighty-five patients between the ages of 30 and 50 years will be enrolled. Optical coherence tomography, magnetic resonance imaging, and ultrasound-based techniques will be used to examine the crystalline lens, ciliary body, and geometric relationship of the structures. The accommodated and unaccommodated eye will be imaged, and the patient's accommodative response will be measured with auto-refraction and photorefraction. Computer-based image processing tools will be used to objectively analyze the images. The results will advance the understanding of the ocular changes associated with presbyopia and will allow for the development of future treatment options.

描述（由申请人提供）：该BCD奖的目标是：1）培训Kathryn Richdale，OD MS作为跨学科的临床医生，2）进一步阐明了与长老会相关的结构和机械变化。 NIH的新路线图计划之一是创建跨学科研究团队，这些研究团队更加“分析成熟”，并将“产生新鲜和意外的见解”；该项目将实现这一目标。提出了一个五年的职业发展计划，包括在生物医学工程，放射学，数学和基于计算机的图像处理方面的正式课程和培训。人们对与长老会相关的眼部变化仍然有限。以前的许多工作都集中在镜头的功能或睫状体的功能上，但未能对整个适应性系统提供全面的看法。先前的研究受到了无法可视化体内人眼的内部结构的限制。使用与人类不完全相似的动物模型使研究变得困惑。已知会影响正常生理的药理剂 回复;验尸的固有变化固有的尸体眼睛；并使用非生理力量进行了体内工作，并打折了虹膜，玻璃体和脉络膜的作用。长老会可能是一个多因素过程，因为没有一种机制能够解释早期发作，持续线性下降和功能完全丧失。为了检验将支持毛皮理论和/或长老会外脑外理论的假设，我们将在人类成年人中对体内的体内形象形象和分析，并确定这些结构如何随着年龄和适应性的努力而变化。在30至50岁之间的八十五名患者将入学。光学相干断层扫描，磁共振成像和基于超声的技术将用于检查结构的结晶透镜，睫状体和几何关系。将成像可容纳和不可安装的眼睛，并将通过自动折磨和光折射来测量患者的谦虚反应。基于计算机的图像处理工具将用于客观地分析图像。结果将提高对与长老会相关的眼部变化的理解，并允许发展未来的治疗选择。