In Vivo Evaluation of Presbyopia

老花眼的体内评估

• 批准号: 8312618
• 负责人: KATHRYN RICHDALE
• 金额: $ 17.09万
• 依托单位: STATE COLLEGE OF OPTOMETRY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8312618
• 关键词: Adult; Affect; Age; Aging-Related Process; Agreement; Algorithms; Animal Model; Anterior; Area; Award; Biomedical Engineering; Body Size; Caliber; Choroid; Ciliary Body; Ciliary Muscle; Collaborations; Computers; Contracts; Crystalline Lens; Development; Dimensions; Elements; Enrollment; Etiology; Evaluation; Eye; Future; Goals; Human; Image; Image Analysis; Instruction; Interdisciplinary Study; Iris; Lead; Life; Literature; Location; Magnetic Resonance Imaging; Mathematics; Measurement; Measures; Mechanics; Mentors; Modeling; Optical Coherence Tomography; Optics; Patients; Physiological; Play; Population; Presbyopia; Process; Radiology Specialty; Research; Role; Scientist; Stimulus; Structure; System; Techniques; Testing; Thick; Time; Training; Ultrasonography; Variant; Vision research; Width; Work; base; career development; cohort; discounting; early onset; image processing; in vivo; insight; lens; loss of function; normal aging; novel; programs; response; theories; tool

The goals of this BCD award are to: 1) train Kathryn Richdale, OD MS as an interdisciplinary clinician- scientist and 2) further elucidate the structural and mechanical changes associated with presbyopia. One of the NIH's new Roadmap initiatives is to create interdisciplinary research teams that are more "analytically sophisticated" and will "yield fresh and unexpected insights;" this project will achieve that aim. A five-year career-development program is proposed, consisting of formal coursework and training in biomedical engineering, radiology, mathematics and computer-based image processing. There is still limited understanding of the ocular changes associatedwith presbyopia. Much of the previous work has focused on either the function of the lens or of the ciliary body, but has failed to provide a comprehensive view of the entire accommodative system. Previous research has been limited by the inability to visualize the internal structures of the human eye in vivo. Studies have been confounded by the use of animal models not entirely similar to humans; pharmacological agents known to affect the normal physiological response; post mortem changes inherent to the use of cadaveric eyes; and ex vivo work using non- physiological forces and discounting the role of the iris, vitreous, and choroid. Presbyopia may likely be a multifactorial process, as no one mechanism is able to explain the early onset, continued linear decline, and complete loss of function. In order to test hypotheses that would support the lenticular theory and/or the extra- lenticular theory of presbyopia, we will image and analyze the accommodative structures in vivo in a cohort of human adults, and determine how those structures change with age and accommodative effort. Eighty-five patients between the ages of 30 and 50 years will be enrolled. Optical coherence tomography, magnetic resonance imaging, and ultrasound-based techniques will be used to examine the crystalline lens, ciliary body, and geometric relationship of the structures. The accommodated and unaccommodated eye will be imaged, and the patient's accommodative response will be measured with auto-refraction and photorefraction. Computer-based image processing tools will be used to objectively analyze the images. The results will advance the understanding of the ocular changes associated with presbyopia and will allow for the development of future treatment options. RELEVANCE (See instructions): Presbyopia, a loss of focusing ability associated with the normal aging process, affects 100% of the population. A study of the structures of the eye associated with focusing is required to understand the changes involved in presbyopia and to advance the research of new treatment options.

该BCD奖的目标是：1）训练Kathryn Richdale，OD MS，是跨学科的临床医生 - 科学家和2）进一步阐明了与长老会有关的结构和机械变化。中的一个 NIH的新路线图计划是创建跨学科研究团队，这些研究团队更加“分析” 精致的“并将“产生新的和意外的见解；”这个项目将实现这一目标。五年 提出了职业发展计划，包括正式的课程和生物医学培训 工程，放射学，数学和基于计算机的图像处理。 与长老会有关的眼部变化仍然有限。以前的大部分 工作集中在镜头的功能或睫状体的功能上，但未能提供 整个适应性系统的全面视图。以前的研究受到了无法 可视化体内人眼的内部结构。使用动物已经混淆了研究 模型与人类不完全相似；已知会影响正常生理的药理剂 回复;验尸的固有变化固有的尸体眼睛；并使用非 - 生理力和打折虹膜，玻璃体和脉络膜的作用。长老会可能是 多因素过程，因为没有一种机制能够解释早期发作，持续线性下降和 完全丧失功能。为了测试将支持毛发理论和/或外部理论的假设 长老会的胸膜理论，我们将在体内形象和分析体内的适应性结构 人类成年人，并确定这些结构如何随着年龄和宽容的努力而变化。 在30至50岁之间的八十五名患者将入学。光学相干断层扫描， 磁共振成像和基于超声的技术将用于检查结晶透镜， 睫状体和结构的几何关系。容纳和不可安排的眼睛将是 成像，将通过自动折磨和照相折射来测量患者的适应性反应。 基于计算机的图像处理工具将用于客观地分析图像。结果将 促进对与长老会相关的眼部变化的理解，并将允许发展 未来的治疗选择。 相关性（请参阅说明）： 长老会是与正常衰老过程相关的集中能力的丧失，会影响100％ 人口。需要研究与聚焦相关的眼睛结构以了解变化 参与长老会，并推进对新治疗方案的研究。