The effects of stress on decision-making in alcohol use disorder: A translational approach

压力对酒精使用障碍决策的影响：转化方法

• 批准号: 10667891
• 负责人: LARA A. RAY
• 金额: $ 18.53万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-15 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10667891
• 关键词: Alcohol consumption; Alcoholic beverage heavy drinker; Alcohols; Amygdaloid structure; Behavioral Model; Chronic stress; Clinical; Clinical assessments; Cognitive; Complex; Decision Making; Female; Functional Magnetic Resonance Imaging; Goals; Human; Image; Individual; Insula of Reil; Investigation; Learning; Literature; Measures; Mediating; Methods; Neurobiology; Outcome; Participant; Predisposition; Prefrontal Cortex; Risk; Role; Sampling; Science; Sorting; Stress; Testing; Wisconsin; acute stress; alcohol use disorder; base; biological adaptation to stress; brain circuitry; chronic alcohol ingestion; clinical diagnosis; cognitive task; comparison control; drinking; eligible participant; flexibility; habit learning; male; neural; neural circuit; neuroimaging; pre-clinical; recruit; response; sex; theories; translational approach; translational impact

ABSTRACT The objective of this translational project is to test the effects of acute stress induction on cognitive flexibility and habit learning among individuals with AUD compared to matched controls. Towards elucidating the complex interplay between alcohol and stress, it is crucial to elucidate brain circuitry and mechanisms that underlie how alcohol and stress interact across a range of domains. To date, much of our understanding of such mechanisms is confined to the preclinical level of analysis. To advance the translational impact of the science of stress and AUD, this application proposes an investigation in a clinical sample with AUD, combining careful experimental manipulations of stress induction, functional magnetic resonance imaging (fMRI), and a well-defined assessment of decision making. We propose to test the effects of acute stress induction on cognitive flexibility (i.e., Wisconsin Card Sort Task; WCST) and habit learning (i.e., Sequential Decision-Making Task; SDMT) in a sample of 64 individuals, 32 non-treatment seeking individuals with AUD and 32 matched controls (no AUD). All participants will complete a chronic stress-informed battery. Baseline measures of cognitive flexibility and habit learning (WCST and SDMT) will be collected. Eligible participants will complete a neuroimaging-based stress-induction task, immediately preceded and followed by assessments of cognitive flexibility and habit learning (WCST and SDMT). The overarching goal is to test whether response to an acute stress induction is associated with decreases on cognitive flexibility and increases in habit learning in individuals with AUD compared to matched controls. If the study hypotheses are supported and acute stress decreases cognitive flexibility and enhances habit learning in individuals with AUD, compared to matched controls, we will undertake large scale (R01-level) studies in which both stress/neural conditions and decision- making measures are completed using neuroimaging paradigms so that neurocircuitry of both stress response and decision-making can be interrogated.

抽象的 该转化项目的目的是测试急性应激诱导对认知灵活性的影响 与匹配的对照组相比，AUD 患者的习惯学习情况。为阐明 酒精和压力之间复杂的相互作用，阐明大脑回路和机制至关重要 酒精和压力如何在一系列领域相互作用。迄今为止，我们的大部分了解 这种机制仅限于临床前分析水平。促进转化影响 压力和 AUD 的科学，该应用程序建议对 AUD 的临床样本进行调查，结合 应力感应、功能磁共振成像 (fMRI) 和 明确的决策评估。我们建议测试急性应激诱导对 认知灵活性（即威斯康星卡片分类任务；WCST）和习惯学习（即顺序决策） 任务; SDMT）在 64 名个体样本中，其中 32 名未寻求治疗的 AUD 个体和 32 名匹配个体 控制（无澳元）。所有参与者都将完成一个慢性压力通知电池组。基线措施 将收集认知灵活性和习惯学习（WCST 和 SDMT）。符合资格的参与者将完成 基于神经影像的压力诱导任务，紧接着进行认知评估 灵活性和习惯学习（WCST 和 SDMT）。总体目标是测试是否对急性反应做出反应 压力诱导与认知灵活性的降低和习惯学习的增加有关 患有 AUD 的个体与匹配的对照相比。如果研究假设得到支持并且急性压力 与匹配的人相比，AUD 患者的认知灵活性降低，习惯学习能力增强 控制，我们将进行大规模（R01级）研究，其中压力/神经状况和决策- 使用神经影像范式完成制定措施，以便压力反应的神经回路 并且决策可以受到质疑。