Puberty-Related Intervention to Improve Metabolic Outcomes - The PRIMO Study

改善代谢结果的青春期相关干预措施 - PRIMO 研究

• 批准号: 7636966
• 负责人: Krista Casazza
• 金额: $ 7.91万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7636966
• 关键词: Acute; Address; Adherence; Admixture; Adolescent; Adult; Affect; African; African American; American; Androgens; Area; Attenuated; Award; Body Composition; Body Weight Changes; Body Weight decreased; Body fat; Carbohydrates; Cereals; Characteristics; Child; Childhood; Collaborations; Deposition; Development; Diet; Diet Modification; Dietary Factors; Dietary Intervention; Effectiveness; Endocrine; Endocrinology; Energy Metabolism; Environment; Estradiol; Estrogens; Ethnic group; European; Evaluation; Fatty acid glycerol esters; Female; Food; Fruit; Funding; Funding Opportunities; Future; Genetic; Goals; Growth and Development function; Guidelines; Health; Hormonal; Hormones; Individual; Insulin; Insulin Resistance; Intake; Intervention; Laboratories; Lead; Life; Maintenance; Measures; Mentors; Metabolic; Metabolic Diseases; Morbidity - disease rate; Non-Insulin-Dependent Diabetes Mellitus; Nonesterified Fatty Acids; Obesity; Outcome; Overweight; Participant; Phase; Physiological; Pilot Projects; Population; Positioning Attribute; Prevention strategy; Principal Investigator; Productivity; Protocols documentation; Puberty; Relative (related person); Reliance; Research; Research Personnel; Research Project Grants; Residual state; Resolution; Rest; Risk; Risk Factors; Satiation; Secure; Testing; Time; Training; Vegetables; Weight; Women' s Health; aged; critical period; emerging adult; girls; improved; insulin secretion; insulin sensitivity; interest; modifiable risk; prevent; public health priorities; public health relevance; racial and ethnic; racial/ethnic difference; reproductive; response; skills; sugar

DESCRIPTION (provided by applicant): The candidate's overarching goal is to develop diet interventions to address pediatric obesity that are specifically tailored to an individual's metabolic profile. Her specific interest is the interaction of diet quality with the changes in insulin secretion and action that occur during the pubertal transition. To achieve this objective, the candidate has identified, as a mentoring team, experts in reproductive/metabolic endocrinology and statistical genetics, both of whom have a proven track record of successful research, collaboration, and productivity. The mentored training secured by this award will involve coursework in genetics, metabolism, and endocrinology; training in laboratory skills; and completion of the candidate's funded pilot study involving a diet intervention in African American peripubertal girls. As the coursework and training progress, there is a planned transition to developing a research protocol, and training in the skills needed for its conduct. Emphasis also will be on cultivation of funding opportunities for future projects. The candidate's proposed research project builds on her previous and ongoing research in adults and children, which has identified dietary factors that affect insulin secretion and obesity. Specifically, the proposed study aims to determine if a diet specialized for the unique metabolic characteristics of peripubertal girls (i.e. low insulin sensitivity/high insulin secretion) is more effective than a standard diet in, 1) decreasing insulin secretion and increasing insulin sensitivity; 2) achieving greater weight loss and weight-loss maintenance; and 3) decreasing estradiol concentration, which may affect fat deposition during the pubertal transition. The specialized diet emphasizes modification of diet quality, particularly carbohydrate quantity/quality. The ultimate goal of this project, and related future research, is to develop dietary guidelines for overweight adolescents tailored to their individual metabolic profile. Effective modification of the diet to improve metabolic and obesity-related outcomes will reduce reliance on pharmacological agents. The outstanding scientific environment afforded by the UAB will allow for continued professional growth and development. Further, the K99 will be the perfect opportunity for the to transition into an independent investigator in the area of pediatric obesity. PUBLIC HEALTH RELEVANCE: Dietary interventions that can be utilized to improve metabolic outcomes and enhance weight-loss and weight-loss maintenance among the pediatric population are imperative. Puberty has been identified as a critical period of body composition determination. Training afforded by this K99 award will better position the candidate to complete the proposed study, which represents the first step in developing a diet that is specific for the unique metabolic characteristics of peripubertal girls.

描述（由申请人提供）： 候选人的总体目标是制定饮食干预措施，以解决专门针对个人的代谢概况量身定制的小儿肥胖症。她的特定兴趣是饮食质量与青春期过渡过程中胰岛素分泌和作用的变化的相互作用。为了实现这一目标，候选人是一个指导团队，是生殖/代谢内分泌学和统计遗传学专家，他们俩都具有成功的研究，协作和生产力的可靠记录。该奖项获得的指导培训将涉及遗传学，代谢和内分泌学的课程；实验室技能培训；并完成了候选人资助的试点研究，涉及对非裔美国人围腹女孩的饮食干预。随着课程和培训的进步，计划过渡到制定研究方案，并在其行为所需的技能上进行培训。重点也将是为未来项目的资金机会培养。候选人提议的研究项目建立在她对成人和儿童的先前和正在进行的研究基础上，该研究确定了影响胰岛素分泌和肥胖症的饮食因素。具体而言，拟议的研究旨在确定专门用于perip伯碱女孩独特代谢特征（即低胰岛素敏感性/高胰岛素分泌）的饮食是否比标准饮食（1）降低胰岛素分泌和提高胰岛素敏感性更有效； 2）实现更大的体重减轻和减轻体重的维持； 3）降低雌二醇浓度，这可能会影响青春期过渡过程中的脂肪沉积。专业饮食强调饮食质量的修饰，尤其是碳水化合物的数量/质量。该项目的最终目标以及相关的未来研究是为针对其个人代谢型量身定制的超重青少年制定饮食指南。有效修改饮食以改善代谢和肥胖相关的结果将减少对药理剂的依赖。 UAB提供的杰出科学环境将允许持续的专业发展和发展。此外，K99将是过渡到小儿肥胖领域的独立研究者的绝佳机会。 公共卫生相关性：可用于改善新陈代谢结果的饮食干预措施，并在小儿种群中增强减肥和减肥减肥。青春期已被确定为身体组成的关键时期。该K99奖项提供的培训将更好地定位候选人，以完成拟议的研究，这代表了开发饮食的第一步，该饮食是针对彼得伯伯尔女孩独特的代谢特征的特定饮食。