Puberty-Related Intervention to Improve Metabolic Outcomes - The PRIMO Study

改善代谢结果的青春期相关干预措施 - PRIMO 研究

• 批准号: 8318599
• 负责人: Krista Casazza
• 金额: $ 24.34万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-11 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8318599
• 关键词: Address; Adherence; Admixture; Adolescent; Adult; Affect; African; African American; Age; American; Androgens; Area; Award; Body Composition; Body Weight Changes; Body Weight decreased; Body fat; Carbohydrates; Characteristics; Child; Childhood; Collaborations; Comorbidity; Deposition; Development; Diet; Diet Modification; Dietary Component; Dietary Factors; Dietary Intervention; Endocrine; Endocrinology; Energy Metabolism; Ensure; Environment; Estradiol; Estrogens; Ethnic group; European; Fatty acid glycerol esters; Female; Food; Funding; Funding Opportunities; Future; Genetic; Goals; Growth; Growth and Development function; Guidelines; Health; Hormonal; Hormones; Individual; Instruction; Insulin; Intervention; Laboratories; Lead; Life; Maintenance; Measures; Mentors; Metabolic; Metabolic Diseases; Metabolism; Metformin; Obesity; Outcome; Overweight; Pharmacotherapy; Phase; Physiological; Pilot Projects; Population; Positioning Attribute; Preventive Intervention; Productivity; Protocols documentation; Puberty; Relative (related person); Reliance; Reporting; Reproduction; Reproductive Process; Research; Research Personnel; Research Project Grants; Rest; Risk; Satiation; Secure; Testing; Time; Tissues; Training; Weight; aged; bone; critical period; design; fitness; genetic association; girls; improved; insulin secretion; insulin sensitivity; interest; oxidation; pubertal timing; racial/ethnic difference; reproductive; reproductive success; response; skills; sugar

The candidate's overarching goal is to develop diet interventions to address pediatric obesity that are specifically tailored to an individual's metabolic profile. Her specific interest is the interaction of diet quality with the changes in insulin secretion and action that occur during the pubertal transition. To achieve this objective, the candidate has identified, as a mentoring team, experts in reproductive/metabolic endocrinology and statistical genetics, both of whom have a proven track record of successful research, collaboration, and productivity. The mentored training secured by this award will involve coursework in genetics, metabolism, and endocrinology; training in laboratory skills; and completion of the candidate's funded pilot study involving a diet intervention in African American peripubertal girls. As the coursework and training progress, there is a planned transition to developing a research protocol, and training in the skills needed for its conduct. Emphasis also will be on cultivation of funding opportunities for future projects. The candidate's proposed research project builds on her previous and ongoing research in adults and children, which has identified dietary factors that affect insulin secretion and obesity. Specifically, the proposed study aims to determine if a diet specialized for the unique metabolic characteristics of peripubertal girls (i.e. low insulin sensitivity/high insulin secretion) is more effective than a standard diet in, 1) decreasing insulin secretion and increasing insulin sensitivity; 2) achieving greater weight loss and weight-loss maintenance; and 3) decreasing estradiol concentration, which may affect fat deposition during the pubertal transition. The specialized diet emphasizes modification of diet quality, particularly carbohydrate quantity/quality. The ultimate goal of this project, and related future research, is to develop dietary guidelines for overweight adolescents tailored to their individual metabolic profile. Effective modification of the diet to improve metabolic and obesity-related outcomes will reduce reliance on pharmacological agents. The outstanding scientific environment afforded by the DAB will allow for continued professional growth and development. Further, th K99 will be the perfect opportunity for the to transition into an independent investigator in the area of pediatric obesity.

候选人的总体目标是制定饮食干预措施，以解决儿科肥胖症 专门针对个人的代谢剖面量身定制。她的特定兴趣是饮食质量的相互作用 随着青春期过渡期间胰岛素分泌和作用的变化。实现这一目标 候选人的目标是，作为一个指导团队，是生殖/代谢内分泌学专家 和统计遗传学，他们都有成功的研究，协作和 生产率。该奖项获得的指导培训将涉及遗传学，代谢， 和内分泌学；实验室技能培训；并完成候选人资助的试点研究 饮食干预非裔美国人腹膜女孩。随着课程和培训的进展，有一个 计划过渡到制定研究方案，并培训其行为所需的技能。 重点也将是为未来项目的资金机会培养。候选人的建议 研究项目基于她以前对成人和儿童正在进行的研究，这已经确定 影响胰岛素分泌和肥胖的饮食因素。具体而言，拟议的研究旨在确定是否是否 饮食专门针对腹膜女孩独特的代谢特征（即胰岛素敏感性低/高 胰岛素分泌）比标准饮食更有效，1）减少胰岛素分泌并增加 胰岛素敏感性； 2）实现更大的体重减轻和减轻体重的维持； 3）减少雌二醇 浓度，可能会影响青春期过渡期间脂肪沉积。专业饮食 强调修饰饮食质量，尤其是碳水化合物的数量/质量。最终目标 项目以及相关的未来研究是为量身定制的超重青少年制定饮食指南 他们的个人代谢概况。有效修改饮食以改善代谢和肥胖相关的饮食 结果将减少对药理剂的依赖。杰出的科学环境提供了 通过DAB，将允许持续的专业发展和发展。此外，TH K99将是完美的 过渡到小儿肥胖领域的独立研究者的机会。