SERUM SELENIUM LEVELS AND THYROID CANCER DEVELOPMENT

血清硒水平与甲状腺癌的发展

• 批准号: 7719075
• 负责人: JACQUELINE JONKLAAS
• 金额: $ 0.29万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719075
• 关键词: Affect; Computer Retrieval of Information on Scientific Projects Database; Data; Development; Diagnosis; Funding; Gender; Grant; Institution; Malignant neoplasm of thyroid; Patients; Pilot Projects; Research; Research Personnel; Resources; Selenium; Serum; Source; Thyroid Gland; Thyroid carcinoma; Tissues; United States National Institutes of Health; cancer diagnosis; case control; design

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is designed to determine whether there is an association between serum and tissue concentrations of selenium and the diagnosis of thyroid cancer, and if so, whether the association is gender-specific. The study is a cross-sectional, case-controlled pilot project designed to collect data over a one-year period form a single center. The objectives are four-fold. The first is to determine whether serum selenium levels are lower in patients who developed thyroid cancer within the preceding 10 years, compared with controls. The second objective is to determine whether any relationship between a thyroid cancer diagnosis and serum selenium levels is affects by patient gender. The third objective is to determine whether tissue selenium levels are lower in the thyroid glands of patients with a diagnosis of thyroid cancer, compared with controls. The final objective is to determine whether any relationship between the presence of thyroid cancer and tissue selenium levels is affected by patient gender.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究旨在确定硒的血清和组织浓度与甲状腺癌的诊断之间是否存在关联，如果是，该关联是否特定于性别。该研究是一个横断面，案例对照的试点项目，旨在在一个单一中心构成一年的数据中收集数据。目标是四倍。首先是确定与对照组相比，在前10年内患甲状腺癌的患者中血清硒水平是否较低。第二个目标是确定甲状腺癌诊断与血清硒水平之间是否受到患者性别的影响。与对照组相比，第三个目标是确定甲状腺诊断患者的甲状腺甲状腺水平是否较低。最终目标是确定甲状腺癌和组织硒水平的存在之间是否受患者性别的影响。