IDENTIFICATION OF LEUKOCYTE GENES THAT ARE REGULATED BY THYROID HORMONE

受甲状腺激素调节的白细胞基因的鉴定

• 批准号: 7608289
• 负责人: JACQUELINE JONKLAAS
• 金额: $ 0.19万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7608289
• 关键词: CD8-Positive T-Lymphocytes; Child; Collaborations; Computer Retrieval of Information on Scientific Projects Database; Detection; Enrollment; Funding; Gene Expression; Genes; Grant; Institution; Leukocytes; Medical center; Proteomics; Protocols documentation; Research; Research Personnel; Resources; Source; Thyroid Hormones; United States National Institutes of Health; cell type; follow-up; monocyte

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specific aim 2 involves identifying a panel of leukocyte genes whose level of expression is altered by thyroid hormone in collaboration with Dr. Eric Hoffman from Children's National Medical Center. Gene expression in two specific cell types: monocytes and CD8 cells is being examined. In addition, we are also planning to perform detection proteomics, in addition to microarray analyses, in the hypothyroid and hyperthyroid subjects enrolled in this study. 14 hypothyroid subjects have been enrolled in and completed the study. One hyperthyroid subject was enrolled in the subject, but unfortunately was lost to follow-up before he completed the protocol. The planned enrollment is 20 hypothyroid and 20 hyperthyroid subjects for a total of 40 subjects

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 特定目标2涉及确定一组白细胞基因，其表达水平与儿童国家医疗中心的埃里克·霍夫曼（Eric Hoffman）博士合作改变了甲状腺激素。两种特定细胞类型的基因表达：正在检查单核细胞和CD8细胞。此外，我们还计划在本研究的甲状腺功能减退和甲状腺功能亢进的受试者中，除了进行微阵列分析外，还计划执行检测蛋白质组学。 14例甲状腺功能减退受试者已入学并完成了研究。该主题招募了一名甲状腺功能亢进的受试者，但不幸的是，在完成协议之前，他失去了随访。计划的入学人数为20个甲状腺功能减退和20名甲状腺功能亢进受试者，共有40名受试者