CHARACTERIZATION OF PROLIFERATING COMPARTMENT IN B-CELL CLL PATIENTS

B 细胞 CLL 患者增殖区的特征

• 批准号: 7719263
• 负责人: Nicholas Chiorazzi
• 金额: $ 4.6万
• 依托单位: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-22 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719263
• 关键词: Adult; Aging; B-Lymphocyte Subsets; B-Lymphocytes; Birth; Blood; Bone Marrow; Cell Cycle Kinetics; Cells; Chromosome abnormality; Chronic Lymphocytic Leukemia; Clinical; Computer Retrieval of Information on Scientific Projects Database; Data; Death Rate; Development; Elderly; Environmental Risk Factor; Family member; Funding; Grant; Individual; Institution; Kinetics; Leukemic Cell; Patients; Prognostic Marker; Proliferating; Relative (related person); Research; Research Personnel; Resources; Rest; Source; United States National Institutes of Health; healthy aging; normal aging

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We propose to: 1. Continue to determine the kinetic profiles of B-CLL cells of untreated patients, from the bone marrow and the blood, to identify the proliferating cells in B-CLL and to correlate these data with specific features of B-CLL cells, clinical course, and the various available prognostic markers. In some instances, subjects previously analyzed for leukemic cell kinetics will be re-studied to determine if birth and death rates have changed. 2. Determine the kinetic profiles of normal blood B cell subsets from healthy aging subjects. The reason for this is to determine any environmental factors that are associated with aging, 50 years or older. 3. Compare the kinetic profiles of B-CLL cells with those of B cell clonal amplifications detectable in some normal aging individuals and unaffected family members who are genetically informative relatives of B-CLL patients. We are looking for genetically similar adults 18 years or older to determine factors that are associated with the development of CLL as well as environmental factors that are associated with aging. 4. Analyze the proliferating B-CLL cells, and the clonally expanded normal B cells from elderly individuals and unaffected family members who are genetically informative relatives of B-CLL patients, for the presence of cytogenetic abnormalities that differ from those of the resting B-CLL pool.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 我们建议： 1。继续确定从骨髓和血液中未经治疗的患者的B-CLL细胞的动力学特征，以鉴定B-CLL中的增殖细胞，并将这些数据与B-CLL细胞的特定特征，临床过程以及各种可用的预后标记相关联。 在某些情况下，将重新研究先前分析白血病细胞动力学的受试者，以确定出生和死亡率是否发生了变化。 2。确定健康衰老受试者正常血液B细胞亚群的动力学特征。 这样做的原因是要确定与衰老相关的任何环境因素，即50岁以上。 3。将B-CLL细胞的动力学特征与在某些正常老龄化个体和未受影响的家庭成员中可检测到的B细胞克隆放大的动力学谱图，这些家人是B-CLL患者的遗传信息丰富的亲戚。 我们正在寻找18岁或以上的遗传相似的成年人，以确定与CLL发展以及与衰老相关的环境因素相关的因素。 4。分析增殖的B-CLL细胞，以及从老年人和未受影响的家族成员的克隆扩展的正常B细胞​​，它们是B-CLL患者的遗传信息，因为存在与静息B-CLL池的细胞遗传学异常，这是B-CLL患者的遗传信息。