CLINICAL TRIAL: A MULTICENTER STUDY EVALUATING THE EFFICACY AND SAFETY OF BOTOX?

临床试验：评估 Botox 功效和安全性的多中心研究？

• 批准号: 7725025
• 负责人: Neal Hermanowicz
• 金额: $ 0.09万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7725025
• 关键词: Affect; Botox; Chronic; Chronic Daily Headaches; Classification; Clinic; Clinical; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Disease; Epidemiologic Studies; Funding; General Population; Grant; Headache; Headache Disorders; Hour; Institution; International; Medical; Multicenter Studies; Neurologic; Population; Recurrence; Research; Research Personnel; Resources; Safety; Societies; Source; Symptoms; Syndrome; United States National Institutes of Health; base; day; medical specialties

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Headache is a common neurological symptom in clinical practice. In 1 year most of the US population will have a headache and over 5% will seek medical aid (Silberstein Silberstein, 1990). Headaches are either episodic (less than 15 headache days/month) or chronic (greater than or equal to 15 headache days/month) (Headache Classification Subcommittee of the International Headache Society, revised 2004 [ICHD-II]). Recurrent headaches (HA) can be symptoms of a chronic primary headache disorder. Primary chronic daily headache (CDH) is a syndrome characterized by HA not attributable to a secondary disorder, which last more than 4 hours/day and occur 16 or more days/month (Bigal et al, 2004; Silberstein and Lipton, 2001). Chronic daily headache is a heterogeneous disorder, affecting approximately 4% to 5% of the general population (based on global epidemiological studies; Castillo et al, 1999; Scher et al, 1998; Wang et al, 2000) and is the most common headache seen in headache specialty clinics.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 头痛是临床实践中常见的神经系统症状。 在1年内，美国大多数人口都会头痛，超过5％的人会寻求医疗援助（Silberstein Silberstein，1990年）。 头痛要么是情节性（小于15个头痛的天气）或慢性（大于或等于15个头痛天/月）（国际头痛协会的头痛分类小组委员会，修订了2004年[iChd-ii]）。 复发性头痛（HA）可能是慢性原发性头痛障碍的症状。 原发性慢性每日头痛（CDH）是一种综合征，其特征是HA并非归因于次要疾病，该疾病持续超过4小时，并且发生了16天或更长时间/月/更长时间（Bigal等，2004； Silberstein and Lipton，2001）。 慢性每日头痛是一种异质性疾病，影响了大约4％至5％的普通人群（基于全球流行病学研究； Castillo等，1999； Scher等，1998； Wang等，2000），是头痛专业诊所中最常见的头痛。