THE EFFECT OF DOXYCYCLINE ON THE EFFICACY OF ORAL CONTRACEPTIVE PILLS

强力霉素对口服避孕药疗效的影响

• 批准号: 7717515
• 负责人: STEPHEN D HALL
• 金额: $ 0.15万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7717515
• 关键词: Anthrax disease; Antibiotics; Bioterrorism; Breakthrough Bleeding; Computer Retrieval of Information on Scientific Projects Database; Contraceptive Agents; Disease Outbreaks; Dose; Doxycycline; Drug Interactions; Drug Kinetics; Ethinyl Estradiol; Follicle Stimulating Hormone; Frequencies; Funding; Grant; Infection; Institution; Label; Long-Term Effects; Luteinizing Hormone; Oral; Oral Contraceptives; Ovulation; Plasma; Progesterone; Research; Research Personnel; Resources; Source; Steroids; Surrogate Markers; United States National Institutes of Health; contraceptive efficacy; indexing; interest; pill; volunteer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The drug interaction between oral contraceptives and oral antibiotics may reduce the exposure of the body to the contraceptive steroids leading to the legitimate concern that contraceptive efficacy may be reduced or lost. This potential for reduced efficacy has become more likely in recent years because of the lower recommended doses of oral contraceptives and the frequency with which antibiotics and oral contraceptives are co-prescribed. An interaction with doxycycline is of particular interest because of the expected widespread use of this antibiotic during an outbreak of anthrax infection following a bioterrorism attack. We plan to quantify the effect long-term doxycycline dosing on the pharmacokinetics ethinylestradiol and nonrethindrone and on the plasma concentrations of luteinizing hormone (LH), follicle stimulating hormone (FSH) and progesterone as surrogate markers of ovulation. The frequency of breakthrough bleeding will be determined as an additional index of oral contraceptive efficacy. This will be an open-label, fixed order, two-period (two cycle per period), study of 24 volunteers.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 口服避孕药和口服抗生素之间的药物相互作用可能会减少身体对避孕类固醇的暴露，导致人们合理地担心避孕效果可能会降低或丧失。 近年来，由于口服避孕药推荐剂量的降低以及抗生素和口服避孕药联合处方的频率降低，这种功效降低的可能性变得更加可能。与强力霉素的相互作用特别令人感兴趣，因为这种抗生素预计会在生物恐怖袭击后爆发炭疽感染期间广泛使用。 我们计划量化长期服用多西环素对炔雌醇和非视黄酮药代动力学的影响，以及对作为排卵替代标志物的黄体生成素 (LH)、卵泡刺激素 (FSH) 和黄体酮血浆浓度的影响。突破性出血的频率将被确定为口服避孕药功效的附加指标。 这将是一项开放标签、固定顺序、两个周期（每个周期两个周期）的研究，有 24 名志愿者参与。