THE DISPOSITION OF ACETAMINOPHEN AND FEXOFENADINE ALONE AND IN COMBINATION IN HE

对乙酰氨基酚和非索非那定单独和组合在 HE 中的处置

• 批准号: 7606463
• 负责人: STEPHEN D HALL
• 金额: $ 3.15万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606463
• 关键词: Acetaminophen; Blood; Computer Retrieval of Information on Scientific Projects Database; Funding; Goals; Grant; Hematologic Agents; Institution; Parents; Pharmaceutical Preparations; Randomized; Research; Research Personnel; Resources; Sampling; Source; United States National Institutes of Health; Urine; fexofenadine; healthy volunteer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of the proposed study is to determine whether the drugs acetaminophen and fexofenadine interact pharmacokinetically. Twenty healthy volunteers will receive acetaminophen and fexofenadine on separate occasions and together. The order of drug administration will be randomized. Serial blood and urine samples will be collected and analyzed for parent drug (blood and urine) and metabolites (urine). We anticipate a lack of interaction between these two compounds.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 拟议研究的目的是确定药物对乙酰氨基酚和非索非那定是否存在药代动力学相互作用。 二十名健康志愿者将分别或一起接受对乙酰氨基酚和非索非那定。 给药顺序将是随机的。 将收集连续血液和尿液样本并分析母体药物（血液和尿液）和代谢物（尿液）。 我们预计这两种化合物之间缺乏相互作用。