Data Management and Statistical Core

数据管理与统计核心

基本信息

批准号：
10666437
负责人：
Kumar B. Rajan
金额：
$ 33.29万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-15 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10666437
关键词：
Alzheimer&apos s Disease Architecture Area Biological Markers Biostatistical Methods Blood Characteristics Clinical Clinical Data Clinical Research Cognitive Cognitive aging Collaborations Communities Complex Computer Systems Data Data Collection Data Management Resources Data Security Data Set Database Management Systems Databases Dementia Development Disease Disease Progression Education Enrollment Faculty Goals Heterogeneity Histology Image Impaired cognition Impairment Individual Infrastructure International Internet Java Lead Leadership Life Cycle Stages Longitudinal cohort Measures Mentors Methodology Modeling Monitor Non-linear Models Online Systems Onset of illness Pathogenesis Pathology Physiological Population Heterogeneity Postdoctoral Fellow Procedures Process Qualifying Quality Control Reporting Reproducibility Research Research Design Research Personnel Resources Risk Factors Sampling Science Secure Source Statistical Methods Summary Reports System Techniques Time Training analytical method biomarker development clinical diagnosis cognitive function cognitive testing cohort computerized data processing data access data framework data integration data management data portal data quality data reduction data sharing design dynamic system education research electronic data electronic data capture system endophenotype epidemiology study follow-up graduate student healthy aging high dimensionality improved innovation longitudinal analysis meetings multi-ethnic neuroimaging neuropathology next generation novel operation outreach recruit research faculty resilience statistics tool undergraduate student user-friendly web app web based interface

项目摘要

PROJECT SUMMARY – Data Management and Statistics Core (DMSC) The overall objective of the Data Management and Statistics Core (DMSC) is to provide a unified and integrative framework for data management, statistical support, and mentoring to enhance the UC Davis Alzheimer’s Disease Research Center (UCD ADRC) goals. To support the goals of the UCD ADRC, the DMSC will focus on four specific aims: 1) continue modernizing our data management system using a secure and dynamic web-based interface and integrate processes with other ADRC cores emphasizing data collection, data management, creation of study reports, and a data-sharing portal; 2) provide project development and analysis support to ADRC investigators and other AD researchers through standard and innovative statistical methods; 3) develop and implement multiple biomarkers approaches for pathogenesis using data across ADRC cores; and 4) in collaboration with the Research Education Component, mentor the next generation of researchers on biostatistical methods and study design. The DMSC brings together a qualified team with expertise in data management, analysis of longitudinal and neuroimaging data, and the conduct of and integration with epidemiology studies and mentoring of junior research faculties across the UC Davis and AD research communities. The DMSC serves a central integrative function for the ADRC, including a web-based data management system that allows de-identified access to current data, and administrative, tracking, and summary reports. Expertise provided by the DMSC leaders enables the use of sophisticated statistical approaches with high impact scientific discoveries. The DMSC will provide innovative solutions for data integration across all UCD ADRC cores and provide standard and novel statistical approaches for disseminating the complicated relationship between risk factors and long-term cognitive decline and dementia progression in diverse populations. The DMSC will also continue to lead in mentoring and training graduate students, postdocs, and junior faculties and collaborate with AD researchers nationally and internationally.

项目摘要 – 数据管理和统计核心 (DMSC) 数据管理和统计核心（DMSC）的总体目标是提供一个统一的、数据管理、统计支持和指导的综合框架，以增强加州大学戴维斯分校的能力阿尔茨海默病研究中心 (UCD ADRC) 的目标为了支持 UCD ADRC 的目标，DMSC。将重点关注四个具体目标：1）继续使用安全可靠的方式实现我们的数据管理系统现代化基于网络的动态界面，并将流程与其他 ADRC 核心集成，强调数据收集， 2) 提供项目开发和数据管理、研究报告创建和数据共享门户；通过标准和创新的统计为 ADRC 调查人员和其他 AD 研究人员提供分析支持方法；3）利用跨领域的数据开发和实施多种发病机制生物标志物方法 ADRC 核心；4) 与研究教育部门合作，指导下一代 DMSC 汇集了一支合格的生物统计方法和研究设计研究人员。数据管理、纵向和神经影像数据分析以及执行和分析方面的专业知识与流行病学研究相结合，并对加州大学戴维斯分校和 AD 的初级研究人员进行指导 DMSC 为 ADRC 提供核心综合功能，包括基于网络的功能。数据管理系统，允许对当前数据进行去识别化访问，并进行管理、跟踪和 DMSC 领导者提供的专业知识使得复杂的统计数据得以使用。 DMSC 将为数据提供创新的解决方案。跨所有 UCD ADRC 核心的集成，并提供标准和新颖的统计方法传播危险因素与长期认知能力下降和痴呆之间的复杂关系 DMSC 还将继续在指导和培训毕业生方面发挥领导作用。学生、博士后和初级教师，并与国内外的 AD 研究人员合作。