LIBMAN-SACKS ENDOCARDITIS AND NEUROPSYCHIATRIC SYSTEMIC LUPUS ERTHENMATOSUS

LIBMAN-SACKS 心内膜炎和神经精神系统性红斑狼疮

• 批准号: 7716607
• 负责人: CARLOS A ROLDAN
• 金额: $ 2.81万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716607
• 关键词: Brain; Brain Injuries; Cerebrum; Computer Retrieval of Information on Scientific Projects Database; Data; Disease remission; Endocarditis; Funding; Grant; Institution; Lesion; Lupus; Patients; Perfusion; Purpose; Recurrence; Research; Research Personnel; Resources; Source; Systemic Lupus Erythematosus; United States National Institutes of Health; improved; neuropsychiatry

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is: 1) To determine cross-sectionally in SLE subjects the effects of valve vegetations detected by TEE on the presence of active cerebral microemboli, altered perfusion, ischemic brain lesions, and NPSLE. Findings in SLE patients will be compared to those in controls. 2) To determine longitudinally in patients with new or recurrent NPSLE and during remission whether valve vegetations, active cerebral microemboli, and abnormal cerebral perfusion improve, or normalize when compared to baseline data in patients without NPSLE or matched controls. 3) To determine cross-sectionally in SLE subjects the presence of active cerebral microemboli, altered brain perfusion, brain injury, and NPSLE in relation to other valve abnormalities, such as valve thickening or valve regurgitation, in addition to or independently of valve vegetations; and to determine longitudinally these relationships in patients with NPSLE. Findings in SLE patients will be compared to baseline data in patients without NPSLE or matched controls.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究的目的是： 1）在SLE受试者中确定横截面，Tee检测到的瓣膜植被对活性脑微栓塞的存在，灌注改变，缺血性脑损伤和NPSLE的影响。将SLE患者的发现与对照组的发现。 2）在具有新的或复发性NPSLE的患者以及在缓解期间的纵向确定瓣膜植被，活跃的脑微栓塞和脑灌注异常，或与无NPSLE或匹配对照的患者的基线数据相比，是否会改善或正常化。 3）为了确定SLE受试者的横截面，与其他瓣膜异常相关的脑灌注，脑损伤和NPSL的存在，除了或独立于瓣膜植被外，还改变了与其他瓣膜异常相关的NPSLE（例如瓣膜增厚或瓣膜反流）；并在NPSLE患者中纵向确定这些关系。 将SLE患者的发现与无NPSLE或匹配对照的患者的基线数据进行比较。