THE PLEIOTROPIC EFFECTS OF ATORVASTATIN WHEN COMBINED WITH

阿托伐他汀与阿托伐他汀联合使用时的多效作用

• 批准号: 7716588
• 负责人: Kathleen Colleran
• 金额: $ 0.05万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716588
• 关键词: Adherence; Amlodipine; Blood Pressure; Coagulation Process; Combination Medication; Computer Retrieval of Information on Scientific Projects Database; Dose; Funding; Goals; Grant; Homocysteine; Homocystine; Hydrochlorothiazide; Hypertension; Inflammation; Institution; Insulin Resistance; Interleukin-6; Lasers; Measures; Oxidative Stress; Patients; Peroxidase; Peroxidases; Plasminogen Activator Inhibitor 1; Rate; Research; Research Personnel; Resources; Serum; Source; Thiobarbituric Acid Reactive Substances; United States National Institutes of Health; adiponectin; atorvastatin; brachial artery; improved; lipoprotein-associated phospholipase A(2); pill; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The combination medication amlodipine/atorvastatin will have improved insulin resistance, increased adherence, and enhanced pleiotropic effects of endothelial function, inflammation, oxidative stress, and coagulation when compared to co-adminstered HCTZ and atorvastatin. This study will - 1. Compare the plieotropic effects of Amlodipine vs. HCTZ when added to a statin on: a. endothelial function: via brachial artery laser probe b. inflammation: by measuring serum hsCRP, IL-6, and TNFol c. Oxidative stess: by measuring serum TBAR, Lp-PLA2, glutathionine peroxidase, and MDA d. Coagulation: by masuring serum PAI-1 and homocysteine 2. To determine if there is a dose response curve of atrovastatin, amlodipine and HCTZ on these pleiotropic effects. 3. To determine the effects of HCTZ versus Amlodipine on insulin resistance in patients treated with a statin by measuring HOMA and adiponectin. 4. To determine the effects of these two agents on the nocturnal dip in blood pressure in patients treated with a statin. 5. To compare adherence and rates of attaining JNC VII and NCEP III goals for hypertension andhyperlididemia with combination Amlodipine/atorvastatin (1 pill) versus co-administered HCTZ and Atorvastatin (2 pills).

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 与共同吸收的HCTZ HCTZ和Atorvastatin相比，组合药物氨氯地平/阿托伐他汀将具有提高胰岛素抵抗，粘附性的提高，增强了内皮功能，炎症，氧化应激和凝结的多效性。 这项研究将 - 1。比较氨氯地平与HCTZ的质感作用 他汀类药物： 一个。内皮功能：通过肱动脉激光探针 b。炎症：通过测量血清HSCRP，IL-6和TNFOL c。氧化梗：通过测量血清TBAR，LP-PLA2，谷胱甘肽 过氧化物酶和MDA d。凝结：通过确定血清PAI-1和同型半胱氨酸 2。确定Atrovastatin的剂量反应曲线是否存在氨氯地平 和HCTZ对这些多效应作用。 3。确定HCTZ与氨氯地平对胰岛素抵抗的影响 在用他汀类药物治疗的患者中，通过测量HOMA和脂联素治疗。 4。确定这两种药物对血液中夜间浸的影响 用他汀类药物治疗的患者的压力。 5。比较达到JNC VII和NCEP III目标的依从性和速度 与组合的高血压和缺血血症 氨氯地平/阿托伐他汀（1丸）与共同管理的HCTZ和 阿托伐他汀（2片）。