CYTOKINE ACTIVATION AND PROTEIN CATABOLISM IN ESRD

ESRD 中的细胞因子激活和蛋白质分解代谢

• 批准号: 7716611
• 负责人: Dominic S Raj
• 金额: $ 3.05万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716611
• 关键词: Albumins; Catabolism; Computer Retrieval of Information on Scientific Projects Database; Cytokine Activation; End stage renal failure; Fibrinogen; Funding; Grant; Institution; Muscle Proteins; Oral; Proteins; Rate; Research; Research Personnel; Resources; Source; Supplementation; United States National Institutes of Health; protein degradation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The principal aims of this appliation are to examine the effect of (a) decreased cytokine activation and (b) combined effect of oral EAA supplementation along with decreased intra-dialytic cytokine activation on whole body protein turnover and fractional synthesis (FSR), and fractional breakdown (FBR) rates of muscle protein, albumin and fibrinogen in ESRD.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该应用的主要目的是检查 (a) 细胞因子激活减少和 (b) 口服 EAA 补充剂以及透析内细胞因子激活减少的综合效应对全身蛋白质周转和分数合成 (FSR) 以及分数的影响。 ESRD 中肌肉蛋白、白蛋白和纤维蛋白原的分解 (FBR) 率。