FSH AND THE ONSET OF PUBERTY--GANIRELIX

FSH 与青春期的开始--GANIRELIX

• 批准号: 7718518
• 负责人: CAROL M FOSTER
• 金额: $ 1.6万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718518
• 关键词: Agonist; Child; Computer Retrieval of Information on Scientific Projects Database; Delayed Puberty; Disease; Follicle Stimulating Hormone; Follistatin; Funding; Grant; Inhibin A; Institution; Lead; Pathogenesis; Peptides; Pilot Projects; Production; Puberty; Regulation; Research; Research Personnel; Resources; Role; Source; Time; United States National Institutes of Health; activin A; ganirelix; response; Agonist; Child; Computer Retrieval of Information on Scientific Projects Database; Delayed Puberty; Disease; Follicle Stimulating Hormone; Follistatin; Funding; Grant; Inhibin A; Institution; Lead; Pathogenesis; Peptides; Pilot Projects; Production; Puberty; Regulation; Research; Research Personnel; Resources; Role; Source; Time; United States National Institutes of Health; activin A; ganirelix; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective of this research is to determine whether differences in the timing of puberty may be explained by alterations in the elaboration of FSH under the control of the FSH-regulatory peptides. We will determine how these peptides relate to FSH production in prepubertal and pubertal children by comparing the regulation of FSH control in children with precocious puberty and delayed puberty. In this pilot study, we will stimulate the pubertal axis using an agonist of GnRH to determine the pubertal response of activin-A, inhibin-A and B and follistatin. To determine baseline FSH secretion and FSH-regulatory peptide tone, we will block GnRH with a specific antagonist. These studies should lead to a better understanding of the role of FSH in controlling the onset of puberty and the pathogenesis of pubertal disorders.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究的目的是确定青春期时间的差异是否可以通过在FSH调节性肽的控制下阐述FSH的改变来解释。 我们将通过比较早熟青春期和延迟青春期的儿童的FSH控制调节来确定这些肽如何与青春期和青春期儿童的FSH产生相关。 在这项试点研究中，我们将使用GNRH的激动剂来刺激青春期轴，以确定激活蛋白A，抑制蛋白A和B和Follistatin的青春期反应。 为了确定基线FSH分泌和FSH调节性肽张音，我们将用特定的拮抗剂阻止GNRH。 这些研究应更好地理解FSH在控制青春期和青春期疾病发病机理中的作用。