EFFECT OF OBESITY CONTROL ON GROWTH

肥胖控制对生长的影响

• 批准号: 6297015
• 负责人: CAROL M FOSTER
• 金额: $ 0.02万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6297015
• 关键词: caloric dietary content; child (0-11); child physical development; clinical research; hormone binding protein; human subject; insulin; insulinlike growth factor; leptin; nutrition; nutrition related tag; obesity; somatotropin; weight control

Growth hormone is important in producing normal growth in children, but the means by which it does so are not known. It may be that several forms of growth hormone are produced, but not all the forms can be recognized in the tests presently used to measure the blood content of growth hormone. This research will determine whether the forms of growth hormone change with nutritional changes at puberty by measuring blood concentrations of growth hormone using a new biological assay. The effect of weight loss to increase growth hormone concentration and biological activity will also be studied. Baseline hormone studies will be performed where blood is obtained through an indwelling catheter every 15 minutes for 24 hours. Then a 12 week intervention will be given by a psychologist and nutritionist to promote weight loss. Following the intervention, blood will again be obtained for 24 hours. These studies may have practical applications for improving growth in children, since new categories for growth failure may be defined. If growth hormone forms with enhanced biological potency can be determined, we may be able to design new drugs to produce better growth. We may be able to better understand the role of growth hormone in metabolism.

生长激素在产生儿童正常生长方面很重要，但尚不清楚这种手段。 可能会产生几种形式的生长激素，但并非所有形式都可以在目前用于测量生长激素的血液含量的测试中识别。 这项研究将通过使用新的生物学测定法测量生长激素的血液浓度来确定生长激素的形式是否随着青春期的营养变化而变化。 体重减轻增加生长激素浓度和生物学活性的影响也将得到研究。 将进行基线激素研究，如果每15分钟通过留置导管获得血液，持续24小时。 然后，心理学家和营养学家将进行12周的干预，以促进体重减轻。 干预后，将再次获得24小时的血液。 这些研究可能在改善儿童的增长方面具有实际应用，因为可能定义了生长失败的新类别。 如果可以确定具有增强生物效力的生长激素形式，我们可能能够设计新药以产生更好的生长。 我们也许能够更好地理解生长激素在代谢中的作用。